C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dihydrofolate reductase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000228716 DHFR 9606 - 5:80626228-80654983 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000439211 DHFR-001 80626228-80654983 protein_coding
  ENST00000504396 DHFR-003 80628223-80654558 protein_coding
  ENST00000505337 DHFR-006 80628017-80654674 protein_coding
  ENST00000508282 DHFR-007 80629064-80654101 retained_intron
  ENST00000511032 DHFR-005 80628124-80654552 protein_coding
  ENST00000513048 DHFR-004 80628538-80654547 processed_transcript
  ENST00000513314 DHFR-008 80648941-80654035 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverMuscleOvaryPlacentaTestisENST00000439211
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Muscle Ovary Placenta Testis
ENST00000439211 2.790±0.00 6.371±0.00 1.158±0.00 4.804±0.00 7.636±6.92 2.825±0.54 0.351±0.13 4.727±0.65 3.750±0.00 0.246±0.00 5.009±2.82 6.090±1.89 8.056±0.77

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000082 TAS G1/S transition of mitotic cell cycle
GO:0000083 TAS regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278 TAS mitotic cell cycle
GO:0003729 IDA mRNA binding
GO:0004146 IDA:IEA dihydrofolate reductase activity
GO:0005575 ND cellular_component
GO:0005654 TAS nucleoplasm
GO:0005829 TAS cytosol
GO:0006545 IEA glycine biosynthetic process
GO:0006730 IEA one-carbon metabolic process
GO:0006766 TAS vitamin metabolic process
GO:0006767 TAS water-soluble vitamin metabolic process
GO:0008144 IDA drug binding
GO:0009165 IEA nucleotide biosynthetic process
GO:0031427 IEA response to methotrexate
GO:0044281 TAS small molecule metabolic process
GO:0046209 TAS nitric oxide metabolic process
GO:0046653 IDA tetrahydrofolate metabolic process
GO:0046654 IEA tetrahydrofolate biosynthetic process
GO:0046655 TAS folic acid metabolic process
GO:0050661 IEA NADP binding
GO:0050999 TAS regulation of nitric-oxide synthase activity
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004251 dhfr dihydrofolate reductase protein_coding Danio_rerio
ENSMUSG00000021707 Dhfr dihydrofolate reductase protein_coding Mus_musculus

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