C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dihydrofolate reductase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021707 Dhfr 10090 + 13:92354783-92389053 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000022218 Dhfr-201 92354783-92389053 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000022218
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000022218 0.839±0.26 1.698±0.54 0.982±0.09 2.169±1.02 0.899±0.25 1.253±0.34 0.393±0.08 8.671±0.61 7.737±3.29 0.674±0.10 0.521±0.07 2.006±0.36 3.198±1.82 0.777±0.10

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002ZB CIL_0002ZB_0002 CGP 13:92354783-92441658

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003729 ISS mRNA binding
GO:0004146 ISS dihydrofolate reductase activity
GO:0005829 TAS cytosol
GO:0006545 IEA glycine biosynthetic process
GO:0006730 IEA one-carbon metabolic process
GO:0008144 ISS drug binding
GO:0009165 IEA nucleotide biosynthetic process
GO:0031427 IEA response to methotrexate
GO:0035094 IEA response to nicotine
GO:0046452 IEA dihydrofolate metabolic process
GO:0046653 ISS tetrahydrofolate metabolic process
GO:0046654 IEA tetrahydrofolate biosynthetic process
GO:0050661 IEA NADP binding
GO:0051871 IEA dihydrofolic acid binding
GO:0055114 IEA oxidation-reduction process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000004251 dhfr dihydrofolate reductase protein_coding Danio_rerio
ENSG00000178700 DHFRL1 dihydrofolate reductase-like 1 protein_coding Homo_sapiens
ENSG00000228716 DHFR dihydrofolate reductase protein_coding Homo_sapiens

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