C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: BRICK1, SCAR/WAVE actin-nucleating complex subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000254999 BRK1 9606 + 3:10115592-10127190 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000530758 BRK1-001 10115592-10127190 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000530758
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000530758 108.723±0.00 98.441±0.00 9.045±0.00 50.356±31.93 55.391±48.53 70.483±60.13 24.441±20.67 43.219±32.90 23.604±9.81 51.916±46.42 21.698±19.68 67.362±50.85 67.134±26.85 86.285±46.38

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00059J CIL_00059J_0001 CGP 3:10081317-10127190
CIL_00061Q CIL_00061Q_0001 CGP 3:10115592-10152220

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001701 IEA in utero embryonic development
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0008284 IEA positive regulation of cell proliferation
GO:0010592 IMP positive regulation of lamellipodium assembly
GO:0016601 IDA Rac protein signal transduction
GO:0030027 ISS lamellipodium
GO:0030036 IEA actin cytoskeleton organization
GO:0031209 IDA SCAR complex
GO:0032403 IDA protein complex binding
GO:0038096 TAS Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 TAS innate immune response
GO:0048365 IDA Rac GTPase binding
GO:0048870 IEA cell motility
GO:0070062 IDA extracellular vesicular exosome
GO:0070207 IDA protein homotrimerization
GO:2000601 IDA positive regulation of Arp2/3 complex-mediated actin nucleation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000041974 BRK1 BRICK1, SCAR/WAVE actin-nucleating complex subunit protein_coding Danio_rerio
ENSMUSG00000033940 Brk1 BRICK1, SCAR/WAVE actin-nucleating complex subunit protein_coding Mus_musculus

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