C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000259207 ITGB3 9606 + 17:47253846-47311816 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000559488 ITGB3-001 47253846-47311816 protein_coding
  ENST00000571680 ITGB3-004 47253853-47291487 protein_coding
  ENST00000573377 ITGB3-005 47291053-47292171 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastLiverLungMuscleOvaryPlacentaENST00000559488ENST00000571680
Transcript ID Adrenal Bladder Brain Breast Liver Lung Muscle Ovary Placenta
ENST00000559488 1.476±0.00 1.869±0.00 0.654±0.00 2.440±0.00 2.463±0.00 0.823±0.00 0.181±0.08 2.470±0.00 1.907±0.28
ENST00000571680 N/A N/A N/A N/A N/A N/A 0.457±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008HD CIL_0008HD_0001 VISTA 17:46991162-47592148
CIL_0004WN CIL_0004WN_0001 CGP 17:47200446-47311816

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001934 TAS positive regulation of protein phosphorylation
GO:0001938 IMP positive regulation of endothelial cell proliferation
GO:0001968 IMP fibronectin binding
GO:0002020 IDA protease binding
GO:0002576 TAS platelet degranulation
GO:0003756 IDA protein disulfide isomerase activity
GO:0004872 IEA receptor activity
GO:0005161 TAS platelet-derived growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005886 IDA plasma membrane
GO:0005887 TAS integral component of plasma membrane
GO:0005925 IDA focal adhesion
GO:0006457 IDA protein folding
GO:0007044 IEA cell-substrate junction assembly
GO:0007155 TAS cell adhesion
GO:0007160 IDA cell-matrix adhesion
GO:0007229 TAS integrin-mediated signaling pathway
GO:0007275 IEA multicellular organismal development
GO:0007411 TAS axon guidance
GO:0007596 TAS blood coagulation
GO:0008305 IDA integrin complex
GO:0009986 IDA cell surface
GO:0010595 IMP positive regulation of endothelial cell migration
GO:0010745 IMP negative regulation of macrophage derived foam cell differentiation
GO:0010888 IMP negative regulation of lipid storage
GO:0014909 IMP smooth muscle cell migration
GO:0016020 IEA membrane
GO:0016049 IMP cell growth
GO:0016477 IMP cell migration
GO:0030168 IMP platelet activation
GO:0030198 TAS extracellular matrix organization
GO:0030334 IEA regulation of cell migration
GO:0030949 TAS positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031092 TAS platelet alpha granule membrane
GO:0031258 IDA lamellipodium membrane
GO:0031527 IDA filopodium membrane
GO:0031528 IDA microvillus membrane
GO:0031589 IMP cell-substrate adhesion
GO:0032147 IMP activation of protein kinase activity
GO:0032369 IMP negative regulation of lipid transport
GO:0032587 IDA ruffle membrane
GO:0034113 IMP heterotypic cell-cell adhesion
GO:0034446 IDA substrate adhesion-dependent cell spreading
GO:0034683 IDA integrin alphav-beta3 complex
GO:0035295 TAS tube development
GO:0038027 IMP apolipoprotein A-I-mediated signaling pathway
GO:0042060 IC wound healing
GO:0042470 IDA melanosome
GO:0042802 IPI identical protein binding
GO:0043184 IPI vascular endothelial growth factor receptor 2 binding
GO:0043235 IDA receptor complex
GO:0045124 TAS regulation of bone resorption
GO:0045715 IMP negative regulation of low-density lipoprotein particle receptor biosynthetic process
GO:0046718 IMP viral entry into host cell
GO:0048333 IEP mesodermal cell differentiation
GO:0050731 IMP positive regulation of peptidyl-tyrosine phosphorylation
GO:0050748 IMP negative regulation of lipoprotein metabolic process
GO:0050839 IPI cell adhesion molecule binding
GO:0050840 IDA extracellular matrix binding
GO:0050900 TAS leukocyte migration
GO:0050919 IMP negative chemotaxis
GO:0060055 TAS angiogenesis involved in wound healing
GO:0070062 IDA extracellular vesicular exosome
GO:0070527 IMP platelet aggregation
GO:0071062 TAS alphav-beta3 integrin-vitronectin complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000045070 itgb3b integrin beta 3b protein_coding Danio_rerio
ENSDARG00000056767 itgb3a integrin beta 3a protein_coding Danio_rerio
ENSMUSG00000020689 Itgb3 integrin beta 3 protein_coding Mus_musculus

Loading