C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000263528 IKBKE 9606 + 1:206470476-206496889 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000578328 IKBKE-004 206470495-206496274 protein_coding
  ENST00000579827 IKBKE-006 206470642-206475135 protein_coding
  ENST00000581977 IKBKE-001 206470495-206496889 protein_coding
  ENST00000584998 IKBKE-003 206470495-206496274 protein_coding
  ENST00000605726 IKBKE-005 206472854-206476260 protein_coding
  ENST00000605818 IKBKE-002 206470476-206478297 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000578328ENST00000579827ENST00000581977ENST00000584998ENST00000605818
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000578328 N/A N/A N/A N/A N/A 0.573±0.00 N/A N/A N/A 0.190±0.00 N/A N/A N/A
ENST00000579827 N/A N/A 0.449±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.225±0.00
ENST00000581977 0.258±0.00 5.242±0.00 N/A 0.206±0.00 0.946±0.00 0.492±0.00 0.069±0.00 1.685±0.00 0.205±0.04 1.788±0.00 1.948±0.62 2.370±0.25 0.507±0.35
ENST00000584998 0.340±0.00 N/A N/A 0.526±0.00 0.386±0.15 N/A N/A N/A 0.113±0.00 N/A 5.099±0.00 1.133±0.00 N/A
ENST00000605818 N/A N/A N/A N/A N/A 0.410±0.00 N/A N/A 0.701±0.00 N/A N/A N/A 0.154±0.00

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004704 IDA NF-kappaB-inducing kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006468 IEA protein phosphorylation
GO:0006955 NAS immune response
GO:0008384 IEA IkappaB kinase activity
GO:0008630 IMP intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010008 TAS endosome membrane
GO:0016605 IDA PML body
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0032480 TAS negative regulation of type I interferon production
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038061 IDA NIK/NF-kappaB signaling
GO:0043123 IEP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 TAS innate immune response

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000070606 ikbke inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon protein_coding Danio_rerio
ENSMUSG00000042349 Ikbke inhibitor of kappaB kinase epsilon protein_coding Mus_musculus

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