C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000581977 IKBKE-001 ENSG00000263528 9606 + 1:206470495-206496889 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungOvaryPlacentaTestisENST00000581977
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Ovary Placenta Testis
ENST00000581977 0.258±0.00 5.242±0.00 0.206±0.00 0.946±0.00 0.492±0.00 0.069±0.00 1.685±0.00 0.205±0.04 1.788±0.00 1.948±0.62 2.370±0.25 0.507±0.35

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0004672 IEA protein kinase activity
GO:0004704 IDA NF-kappaB-inducing kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006468 IDA:IEA protein phosphorylation
GO:0006955 NAS immune response
GO:0008384 IEA IkappaB kinase activity
GO:0008630 IMP intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010008 TAS endosome membrane
GO:0016605 IDA PML body
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0032480 TAS negative regulation of type I interferon production
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038061 IDA NIK/NF-kappaB signaling
GO:0043123 IEP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 TAS innate immune response

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000062108 Ikbke-001 protein_coding Mus_musculus 0 2028
ENSMUST00000161764 Ikbke-002 protein_coding Mus_musculus 0 1670
ENSMUST00000159195 Ikbke-004 protein_coding Mus_musculus 0 455
ENSMUST00000162285 Ikbke-005 retained_intron Mus_musculus 0 403
ENSMUST00000163029 Ikbke-006 retained_intron Mus_musculus 0 307

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