C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: neurofilament, light polypeptide
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000277586 NEFL 9606 - 8:24950955-24957110 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000610854 NEFL-001 24950955-24957110 protein_coding
  ENST00000615973 NEFL-007 24955225-24956721 retained_intron
  ENST00000619417 NEFL-201 24952380-24956612 protein_coding

Homo sapiens EnsemblGRCh38

Genome
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Genes
Gene structures from Ensembl
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Transcripts
Structures from Ensembl
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Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000610854ENST00000615973ENST00000619417
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000610854 N/A 0.070±0.00 0.610±0.00 91.326±36.33 0.055±0.02 1.245±1.17 0.005±0.00 0.847±0.00 0.261±0.00 0.047±0.00 0.019±0.00 0.116±0.07 0.018±0.00 0.451±0.12
ENST00000615973 N/A N/A N/A N/A 0.221±0.11 0.438±0.00 N/A 0.052±0.00 N/A 0.226±0.00 0.026±0.00 0.566±0.39 0.070±0.00 1.178±0.00
ENST00000619417 0.010±0.00 0.070±0.00 0.803±0.00 127.633±104.11 0.205±0.00 2.475±2.02 0.031±0.01 2.568±0.00 N/A N/A 0.025±0.00 0.609±0.05 0.038±0.00 1.461±0.03

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0001YP CIL_0001YP_0002 CGP 8:24913012-24957110

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000226 IEA microtubule cytoskeleton organization
GO:0005198 IEA structural molecule activity
GO:0005200 IDA structural constituent of cytoskeleton
GO:0005515 IPI protein binding
GO:0005737 ISS cytoplasm
GO:0005829 TAS cytosol
GO:0005882 IEA intermediate filament
GO:0005883 IDA neurofilament
GO:0007268 TAS synaptic transmission
GO:0008022 IPI protein C-terminus binding
GO:0008089 IMP anterograde axon cargo transport
GO:0008090 IMP retrograde axon cargo transport
GO:0008219 IEA cell death
GO:0009636 IEA response to toxic substance
GO:0010033 IEA response to organic substance
GO:0010243 IEA response to organonitrogen compound
GO:0014012 IEA peripheral nervous system axon regeneration
GO:0019896 IMP axon transport of mitochondrion
GO:0019904 IEA protein domain specific binding
GO:0030424 IDA axon
GO:0030426 IEA growth cone
GO:0030674 ISS protein binding, bridging
GO:0031133 IEA regulation of axon diameter
GO:0033596 IDA TSC1-TSC2 complex
GO:0033693 IDA neurofilament bundle assembly
GO:0040011 IEA locomotion
GO:0042802 IPI identical protein binding
GO:0043005 IEA neuron projection
GO:0043274 IEA phospholipase binding
GO:0043434 IEA response to peptide hormone
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0045109 IMP intermediate filament organization
GO:0045110 IEA intermediate filament bundle assembly
GO:0048812 IEA neuron projection morphogenesis
GO:0050772 IEA positive regulation of axonogenesis
GO:0050885 IEA neuromuscular process controlling balance
GO:0051258 IEA protein polymerization
GO:0051412 IEA response to corticosterone
GO:0060052 IEA neurofilament cytoskeleton organization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000012426 neflb neurofilament, light polypeptide b protein_coding Danio_rerio
ENSDARG00000057568 nefla neurofilament, light polypeptide a protein_coding Danio_rerio
ENSMUSG00000022055 Nefl neurofilament, light polypeptide protein_coding Mus_musculus

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