C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: neurofilament, light polypeptide
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022055 Nefl 10090 + 14:68083863-68089095 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000022639 Nefl-001 68083863-68089095 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000022639
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000022639 0.022±0.01 2.070±1.42 0.311±0.02 79.788±47.33 0.031±0.01 2.977±0.24 0.230±0.04 0.640±0.31 0.059±0.08 0.023±0.01 0.010±0.00 0.041±0.02 0.171±0.15 0.069±0.01

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000PH CIL_0000PH_0002 CGP 14:67751928-68124846
CIL_0001YP CIL_0001YP_0003 CGP 14:68082590-68124846

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000226 IMP microtubule cytoskeleton organization
GO:0005200 IDA structural constituent of cytoskeleton
GO:0005515 IPI protein binding
GO:0005737 IDA cytoplasm
GO:0005882 IDA intermediate filament
GO:0005883 IDA neurofilament
GO:0008022 IEA protein C-terminus binding
GO:0008089 IEA anterograde axon cargo transport
GO:0008090 IEA retrograde axon cargo transport
GO:0009636 IEA response to toxic substance
GO:0010033 IEA response to organic substance
GO:0010243 IEA response to organonitrogen compound
GO:0014012 IMP peripheral nervous system axon regeneration
GO:0019896 IEA axon transport of mitochondrion
GO:0019904 IEA protein domain specific binding
GO:0030424 IDA axon
GO:0030426 IEA growth cone
GO:0030674 IDA protein binding, bridging
GO:0031133 IMP regulation of axon diameter
GO:0033596 IEA TSC1-TSC2 complex
GO:0033693 IEA neurofilament bundle assembly
GO:0040011 IMP locomotion
GO:0042802 IEA identical protein binding
GO:0043005 IDA neuron projection
GO:0043274 IEA phospholipase binding
GO:0043434 IEA response to peptide hormone
GO:0043524 IMP negative regulation of neuron apoptotic process
GO:0045109 IMP intermediate filament organization
GO:0045110 IGI intermediate filament bundle assembly
GO:0048812 IMP neuron projection morphogenesis
GO:0050772 IMP positive regulation of axonogenesis
GO:0050885 IMP neuromuscular process controlling balance
GO:0051258 IEA protein polymerization
GO:0051412 IEA response to corticosterone
GO:0060052 IGI neurofilament cytoskeleton organization

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000012426 neflb neurofilament, light polypeptide b protein_coding Danio_rerio
ENSDARG00000057568 nefla neurofilament, light polypeptide a protein_coding Danio_rerio
ENSG00000277586 NEFL neurofilament, light polypeptide protein_coding Homo_sapiens

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