C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: peroxisome proliferator activator receptor delta
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000002250 Ppard 10090 + 17:28232754-28301469 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000002320 Ppard-001 28232754-28301469 protein_coding
  ENSMUST00000123020 Ppard-002 28232766-28296379 retained_intron
  ENSMUST00000142226 Ppard-003 28232807-28299939 retained_intron
  ENSMUST00000144200 Ppard-006 28271708-28273163 processed_transcript
  ENSMUST00000166744 Ppard-004 28232782-28299861 processed_transcript
  ENSMUST00000169040 Ppard-005 28272193-28298716 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000002320ENSMUST00000142226ENSMUST00000166744ENSMUST00000169040
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000002320 10.283±3.24 18.478±1.09 11.302±0.63 5.802±3.05 10.907±4.00 80.343±9.51 7.878±1.76 7.439±0.97 3.799±1.38 11.438±1.21 8.815±0.65 9.913±3.96 16.784±14.04 0.757±0.40
ENSMUST00000142226 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.414±0.00 1.853±0.00 N/A
ENSMUST00000166744 6.402±1.35 N/A N/A 3.645±0.00 N/A N/A 3.976±0.01 4.322±0.00 N/A N/A N/A 2.265±0.00 N/A 0.561±0.22
ENSMUST00000169040 N/A N/A N/A 6.472±0.00 N/A N/A N/A N/A N/A N/A N/A 5.442±0.00 17.396±12.43 0.186±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008UQ CIL_0008UQ_0002 VISTA 17:28043766-28646334
CIL_0004LU CIL_0004LU_0003 CGP 17:28207778-28301469
CIL_0002EQ CIL_0002EQ_0002 CGP 17:28232754-28326568

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0001890 IMP placenta development
GO:0003677 IDA DNA binding
GO:0003707 IEA steroid hormone receptor activity
GO:0003713 IEA transcription coactivator activity
GO:0004879 TAS:ISS ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005504 IEA fatty acid binding
GO:0005515 IEA protein binding
GO:0006029 IEA proteoglycan metabolic process
GO:0006629 IMP lipid metabolic process
GO:0006635 IEP fatty acid beta-oxidation
GO:0006776 IEA vitamin A metabolic process
GO:0007186 TAS G-protein coupled receptor signaling pathway
GO:0007507 IEA heart development
GO:0007566 TAS embryo implantation
GO:0008047 TAS enzyme activator activity
GO:0008144 ISS drug binding
GO:0008270 IEA zinc ion binding
GO:0008283 IMP cell proliferation
GO:0008284 IMP positive regulation of cell proliferation
GO:0008289 ISS lipid binding
GO:0008366 IMP axon ensheathment
GO:0008544 TAS epidermis development
GO:0008654 IEA phospholipid biosynthetic process
GO:0009299 IEA mRNA transcription
GO:0009749 IEA response to glucose
GO:0009987 TAS cellular process
GO:0010033 IEA response to organic substance
GO:0014068 IDA positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014823 IEA response to activity
GO:0014912 IEA negative regulation of smooth muscle cell migration
GO:0015908 IEP fatty acid transport
GO:0016501 TAS prostacyclin receptor activity
GO:0019395 IEA fatty acid oxidation
GO:0030154 IDA cell differentiation
GO:0030308 IEA negative regulation of cell growth
GO:0030522 IEA intracellular receptor signaling pathway
GO:0031589 IMP cell-substrate adhesion
GO:0032024 IEA positive regulation of insulin secretion
GO:0032966 IEA negative regulation of collagen biosynthetic process
GO:0033189 IEA response to vitamin A
GO:0042060 IMP wound healing
GO:0042127 IGI regulation of cell proliferation
GO:0043066 IEA negative regulation of apoptotic process
GO:0043085 TAS positive regulation of catalytic activity
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IEA sequence-specific DNA binding
GO:0043616 IMP keratinocyte proliferation
GO:0045598 IMP regulation of fat cell differentiation
GO:0045684 IEA positive regulation of epidermis development
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045909 IEA positive regulation of vasodilation
GO:0046697 IEA decidualization
GO:0046965 TAS retinoid X receptor binding
GO:0046982 TAS protein heterodimerization activity
GO:0048662 IEA negative regulation of smooth muscle cell proliferation
GO:0050680 IGI negative regulation of epithelial cell proliferation
GO:0050728 IEA negative regulation of inflammatory response
GO:0050796 NAS regulation of insulin secretion
GO:0051059 IEA NF-kappaB binding
GO:0051546 IMP keratinocyte migration
GO:0060612 IMP adipose tissue development
GO:0070539 ISS linoleic acid binding
GO:0071456 IGI cellular response to hypoxia
GO:0097190 IEA apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000009473 ppardb peroxisome proliferator-activated receptor delta b protein_coding Danio_rerio
ENSDARG00000044525 pparda peroxisome proliferator-activated receptor delta a protein_coding Danio_rerio
ENSG00000112033 PPARD peroxisome proliferator-activated receptor delta protein_coding Homo_sapiens

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