C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000003518 Dusp3 10090 - 11:101971143-101987013 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000003612 Dusp3-001 101971143-101984799 protein_coding
  ENSMUST00000107172 Dusp3-004 101971143-101987013 protein_coding
  ENSMUST00000107173 Dusp3-003 101971143-101987013 protein_coding
  ENSMUST00000125794 Dusp3-005 101973469-101981688 protein_coding
  ENSMUST00000143177 Dusp3-006 101974716-101984778 protein_coding
  ENSMUST00000151678 Dusp3-002 101971143-101983503 protein_coding
  ENSMUST00000176261 Dusp3-007 101980594-101984751 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000003612ENSMUST00000107172ENSMUST00000107173ENSMUST00000125794ENSMUST00000143177ENSMUST00000151678ENSMUST00000176261
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000003612 17.905±4.40 24.563±1.68 20.180±0.78 5.436±3.95 15.925±1.88 14.599±1.83 15.432±1.02 10.267±1.44 3.607±1.25 33.234±6.48 28.602±1.19 12.132±3.88 5.049±1.98 N/A
ENSMUST00000107172 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.031±0.84
ENSMUST00000107173 8.557±3.80 6.840±0.69 N/A N/A 4.592±1.07 4.282±0.62 3.893±0.22 3.597±1.03 1.176±0.67 7.811±1.18 N/A 4.605±0.61 1.285±0.02 10.733±0.00
ENSMUST00000125794 N/A N/A N/A 108.544±0.00 N/A N/A N/A N/A N/A N/A N/A 25.123±0.00 33.894±1.11 194.938±143.07
ENSMUST00000143177 N/A 26.673±5.18 N/A N/A N/A N/A N/A N/A N/A 52.160±0.00 N/A 19.067±2.41 N/A N/A
ENSMUST00000151678 N/A N/A N/A N/A 11.383±0.00 N/A N/A N/A N/A N/A N/A 6.616±2.26 3.528±0.89 N/A
ENSMUST00000176261 38.407±12.20 54.279±0.19 N/A N/A 29.366±0.91 34.474±3.36 N/A 21.761±0.86 11.524±1.07 61.859±0.00 N/A 27.631±6.91 N/A 60.626±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000996 CIL_000996_0002 VISTA 11:101501412-102102123
CIL_00090X CIL_00090X_0002 VISTA 11:101529827-102131014
CIL_000997 CIL_000997_0002 VISTA 11:101567301-102168287
CIL_0001CB CIL_0001CB_0002 CGP 11:101962458-101987013
CIL_00059Q CIL_00059Q_0002 CGP 11:101971143-101992264

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000188 IEA inactivation of MAPK activity
GO:0001701 IEA in utero embryonic development
GO:0001772 IEA immunological synapse
GO:0004721 IDA phosphoprotein phosphatase activity
GO:0004725 IEA protein tyrosine phosphatase activity
GO:0005634 IEA nucleus
GO:0005829 IBA cytosol
GO:0006470 IDA protein dephosphorylation
GO:0008138 IDA protein tyrosine/serine/threonine phosphatase activity
GO:0033549 IBA MAP kinase phosphatase activity
GO:0035335 IEA peptidyl-tyrosine dephosphorylation
GO:0043409 IEA negative regulation of MAPK cascade
GO:0045931 IBA positive regulation of mitotic cell cycle
GO:0046329 IBA negative regulation of JNK cascade
GO:0050860 IBA negative regulation of T cell receptor signaling pathway
GO:0050868 IBA negative regulation of T cell activation
GO:0070062 IEA extracellular vesicular exosome
GO:0070373 IBA negative regulation of ERK1 and ERK2 cascade

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000061255 dusp3a dual specificity phosphatase 3a protein_coding Danio_rerio
ENSG00000108861 DUSP3 dual specificity phosphatase 3 protein_coding Homo_sapiens

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