C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: signal transducer and activator of transcription 5A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000004043 Stat5a 10090 + 11:100859351-100885169 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000004145 Stat5a-001 100859351-100885169 protein_coding
  ENSMUST00000107356 Stat5a-002 100859656-100885169 protein_coding
  ENSMUST00000107357 Stat5a-201 100860484-100885168 protein_coding
  ENSMUST00000133036 Stat5a-004 100859410-100861747 protein_coding
  ENSMUST00000135272 Stat5a-006 100879019-100880107 processed_transcript
  ENSMUST00000138083 Stat5a-005 100860345-100863220 protein_coding
  ENSMUST00000154087 Stat5a-003 100860485-100877308 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBreastColonHeartKidneyLiverMuscleOvaryPlacentaTestisENSMUST00000107356ENSMUST00000107357
Transcript ID Adipose Adrenal Breast Colon Heart Kidney Liver Muscle Ovary Placenta Testis
ENSMUST00000107356 19.246±3.22 18.491±2.13 30.359±5.83 7.318±0.00 9.384±0.31 5.935±0.48 7.159±1.26 3.518±0.62 21.156±3.30 4.768±0.17 2.827±0.27
ENSMUST00000107357 N/A N/A N/A N/A N/A N/A N/A N/A 12.172±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006I7 CIL_0006I7_0002 CGP 11:100780731-100885169
CIL_0006IK CIL_0006IK_0002 CGP 11:100859351-100939540

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000255 IMP allantoin metabolic process
GO:0000979 IDA RNA polymerase II core promoter sequence-specific DNA binding
GO:0001553 IGI luteinization
GO:0001779 IGI natural killer cell differentiation
GO:0003677 IDA DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0004871 IGI signal transducer activity
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005634 IEA:IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006101 IMP citrate metabolic process
GO:0006103 IMP 2-oxoglutarate metabolic process
GO:0006105 IMP succinate metabolic process
GO:0006107 IMP oxaloacetate metabolic process
GO:0006351 IEA transcription, DNA-templated
GO:0006357 IGI regulation of transcription from RNA polymerase II promoter
GO:0006549 IMP isoleucine metabolic process
GO:0006573 IMP valine metabolic process
GO:0006600 IMP creatine metabolic process
GO:0006631 IMP fatty acid metabolic process
GO:0007259 IDA JAK-STAT cascade
GO:0007565 IGI female pregnancy
GO:0007595 IMP lactation
GO:0008284 IDA positive regulation of cell proliferation
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0019218 IGI regulation of steroid metabolic process
GO:0019221 IDA cytokine-mediated signaling pathway
GO:0019530 IMP taurine metabolic process
GO:0019903 IPI protein phosphatase binding
GO:0019915 IGI lipid storage
GO:0030155 IMP regulation of cell adhesion
GO:0030856 IMP regulation of epithelial cell differentiation
GO:0030879 IMP mammary gland development
GO:0032825 IMP positive regulation of natural killer cell differentiation
GO:0033026 IMP negative regulation of mast cell apoptotic process
GO:0033077 IGI T cell differentiation in thymus
GO:0038161 IDA prolactin signaling pathway
GO:0040014 IDA regulation of multicellular organism growth
GO:0040018 IGI positive regulation of multicellular organism growth
GO:0042104 IDA positive regulation of activated T cell proliferation
GO:0043029 IGI T cell homeostasis
GO:0043066 IGI negative regulation of apoptotic process
GO:0043434 IDA response to peptide hormone
GO:0045086 IGI positive regulation of interleukin-2 biosynthetic process
GO:0045579 IGI positive regulation of B cell differentiation
GO:0045588 IGI positive regulation of gamma-delta T cell differentiation
GO:0045621 IGI positive regulation of lymphocyte differentiation
GO:0045647 IGI negative regulation of erythrocyte differentiation
GO:0045931 IGI positive regulation of mitotic cell cycle
GO:0045944 IGI positive regulation of transcription from RNA polymerase II promoter
GO:0045954 IMP positive regulation of natural killer cell mediated cytotoxicity
GO:0046449 IMP creatinine metabolic process
GO:0046543 IMP development of secondary female sexual characteristics
GO:0046544 IGI development of secondary male sexual characteristics
GO:0048541 IGI Peyer's patch development
GO:0050729 IGI positive regulation of inflammatory response
GO:0060376 IMP positive regulation of mast cell differentiation
GO:0060397 IDA JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060740 IMP prostate gland epithelium morphogenesis
GO:0060742 IMP epithelial cell differentiation involved in prostate gland development
GO:0061180 IGI mammary gland epithelium development
GO:0070668 IMP positive regulation of mast cell proliferation
GO:0097011 IDA cellular response to granulocyte macrophage colony-stimulating factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019392 stat5.1 signal transducer and activator of transcription 5.1 protein_coding Danio_rerio
ENSDARG00000055588 stat5.2 signal transducer and activator of transcription 5.2 protein_coding Danio_rerio
ENSG00000126561 STAT5A signal transducer and activator of transcription 5A protein_coding Homo_sapiens

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