C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: signal transducer and activator of transcription 5A
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000126561 STAT5A 9606 + 17:42287547-42311943 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000345506 STAT5A-001 42287547-42311943 protein_coding
  ENST00000444283 STAT5A-004 42288501-42292061 protein_coding
  ENST00000468096 STAT5A-006 42306114-42310523 retained_intron
  ENST00000469124 STAT5A-002 42288489-42290179 retained_intron
  ENST00000478897 STAT5A-003 42289213-42292037 retained_intron
  ENST00000479417 STAT5A-005 42304179-42306326 retained_intron
  ENST00000546010 STAT5A-008 42288076-42310927 protein_coding
  ENST00000587646 STAT5A-011 42306170-42309686 protein_coding
  ENST00000588868 STAT5A-009 42288543-42311940 protein_coding
  ENST00000590726 STAT5A-012 42288469-42300281 protein_coding
  ENST00000590949 STAT5A-007 42287867-42310860 protein_coding
  ENST00000591556 STAT5A-010 42306116-42308759 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000345506ENST00000588868ENST00000590949
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000345506 N/A N/A N/A 2.774±0.00 N/A N/A 0.328±0.00 N/A 1.279±0.00 N/A 20.006±0.00 N/A N/A
ENST00000588868 33.702±0.00 7.769±0.00 2.035±0.00 50.298±0.00 5.160±3.08 2.219±0.00 3.109±0.00 1.560±0.10 6.331±0.00 7.040±0.00 4.716±0.80 2.454±0.09 4.454±0.00
ENST00000590949 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.385±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006I7 CIL_0006I7_0001 CGP 17:42199168-42311943
CIL_0006IK CIL_0006IK_0001 CGP 17:42287547-42388568

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000255 ISS allantoin metabolic process
GO:0000979 IEA RNA polymerase II core promoter sequence-specific DNA binding
GO:0001553 IEA luteinization
GO:0001779 IEA natural killer cell differentiation
GO:0003677 IEA DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0004871 IEA signal transducer activity
GO:0005509 IEA calcium ion binding
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0006101 ISS citrate metabolic process
GO:0006103 ISS 2-oxoglutarate metabolic process
GO:0006105 ISS succinate metabolic process
GO:0006107 ISS oxaloacetate metabolic process
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 TAS regulation of transcription from RNA polymerase II promoter
GO:0006549 ISS isoleucine metabolic process
GO:0006573 ISS valine metabolic process
GO:0006600 ISS creatine metabolic process
GO:0006631 ISS fatty acid metabolic process
GO:0007165 IEA signal transduction
GO:0007259 TAS JAK-STAT cascade
GO:0007565 IEA female pregnancy
GO:0007595 IEA lactation
GO:0008284 IEA positive regulation of cell proliferation
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0019218 IEA regulation of steroid metabolic process
GO:0019221 IEA cytokine-mediated signaling pathway
GO:0019530 ISS taurine metabolic process
GO:0019915 IEA lipid storage
GO:0030155 IEA regulation of cell adhesion
GO:0030856 IEA regulation of epithelial cell differentiation
GO:0030879 IEA mammary gland development
GO:0032825 IEA positive regulation of natural killer cell differentiation
GO:0033026 IEA negative regulation of mast cell apoptotic process
GO:0033077 IEA T cell differentiation in thymus
GO:0038161 ISS prolactin signaling pathway
GO:0040014 ISS regulation of multicellular organism growth
GO:0040018 IEA positive regulation of multicellular organism growth
GO:0042104 IEA positive regulation of activated T cell proliferation
GO:0043029 IEA T cell homeostasis
GO:0043066 IEA negative regulation of apoptotic process
GO:0043434 IEA response to peptide hormone
GO:0045086 IEA positive regulation of interleukin-2 biosynthetic process
GO:0045579 IEA positive regulation of B cell differentiation
GO:0045588 IEA positive regulation of gamma-delta T cell differentiation
GO:0045621 IEA positive regulation of lymphocyte differentiation
GO:0045647 IEA negative regulation of erythrocyte differentiation
GO:0045931 IEA positive regulation of mitotic cell cycle
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0045954 IEA positive regulation of natural killer cell mediated cytotoxicity
GO:0046449 ISS creatinine metabolic process
GO:0046543 IEA development of secondary female sexual characteristics
GO:0046544 IEA development of secondary male sexual characteristics
GO:0048541 IEA Peyer's patch development
GO:0050729 IEA positive regulation of inflammatory response
GO:0060376 IEA positive regulation of mast cell differentiation
GO:0060397 TAS JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060740 IEA prostate gland epithelium morphogenesis
GO:0060742 IEA epithelial cell differentiation involved in prostate gland development
GO:0061180 IEA mammary gland epithelium development
GO:0070668 IEA positive regulation of mast cell proliferation
GO:0097011 IEA cellular response to granulocyte macrophage colony-stimulating factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000019392 stat5.1 signal transducer and activator of transcription 5.1 protein_coding Danio_rerio
ENSDARG00000055588 stat5.2 signal transducer and activator of transcription 5.2 protein_coding Danio_rerio
ENSMUSG00000004043 Stat5a signal transducer and activator of transcription 5A protein_coding Mus_musculus

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