C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: transcription factor AP4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000005718 Tfap4 10090 - 16:4544661-4559720 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000005862 Tfap4-201 4544661-4559720 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000005862
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000005862 3.906±2.24 0.708±0.17 2.865±0.17 3.705±2.24 2.767±1.15 5.504±0.80 0.575±0.14 1.851±0.20 3.447±3.03 2.229±0.27 1.555±0.48 4.683±1.56 1.390±1.09 0.422±0.22

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00032P CIL_00032P_0002 CGP 16:4480216-4559720
CIL_0000WQ CIL_0000WQ_0002 CGP 16:4544661-4624924

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 IEA DNA binding
GO:0003705 ISS RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006461 IDA protein complex assembly
GO:0006978 IEA DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0008285 IEA negative regulation of cell proliferation
GO:0010629 IDA negative regulation of gene expression
GO:0017053 IMP transcriptional repressor complex
GO:0042803 IEA protein homodimerization activity
GO:0042826 IPI histone deacetylase binding
GO:0043065 IEA positive regulation of apoptotic process
GO:0043392 IEA negative regulation of DNA binding
GO:0043565 IEA sequence-specific DNA binding
GO:0043922 IEA negative regulation by host of viral transcription
GO:0043923 IEA positive regulation by host of viral transcription
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045736 IEA negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IEA positive regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0070888 IDA E-box binding
GO:0071157 IEA negative regulation of cell cycle arrest
GO:0071549 IDA cellular response to dexamethasone stimulus
GO:2001269 IMP positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000074641 tfap4 transcription factor AP-4 (activating enhancer binding protein 4) protein_coding Danio_rerio
ENSG00000090447 TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) protein_coding Homo_sapiens

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