C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: catenin (cadherin associated protein), beta 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000006932 Ctnnb1 10090 + 9:120929216-120960507 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000007130 Ctnnb1-001 120933400-120960507 protein_coding
  ENSMUST00000126633 Ctnnb1-007 120955125-120955841 processed_transcript
  ENSMUST00000130466 Ctnnb1-004 120929216-120950635 protein_coding
  ENSMUST00000130845 Ctnnb1-012 120933623-120951710 nonsense_mediated_decay
  ENSMUST00000133689 Ctnnb1-009 120955914-120959025 protein_coding
  ENSMUST00000139138 Ctnnb1-008 120956867-120957824 retained_intron
  ENSMUST00000145093 Ctnnb1-006 120933818-120951293 protein_coding
  ENSMUST00000154356 Ctnnb1-002 120933475-120960506 nonsense_mediated_decay
  ENSMUST00000154687 Ctnnb1-003 120933486-120956447 retained_intron
  ENSMUST00000156911 Ctnnb1-010 120955297-120957639 processed_transcript
  ENSMUST00000163844 Ctnnb1-011 120950221-120959517 nonsense_mediated_decay
  ENSMUST00000169931 Ctnnb1-005 120955457-120957534 protein_coding
  ENSMUST00000170729 Ctnnb1-013 120951089-120955399 nonsense_mediated_decay
  ENSMUST00000178812 Ctnnb1-201 120933578-120960506 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000007130ENSMUST00000154356ENSMUST00000154687ENSMUST00000178812
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000007130 61.032±33.28 50.190±20.62 55.437±18.60 74.258±18.78 13.064±3.57 61.663±7.03 37.245±5.30 51.358±9.23 24.958±10.01 87.499±22.20 15.612±4.69 22.465±8.15 52.545±31.67 18.795±0.00
ENSMUST00000154356 N/A 19.733±4.29 N/A N/A 8.346±2.55 19.194±5.39 N/A 15.096±0.00 4.291±1.37 20.330±1.61 N/A 15.441±7.65 N/A N/A
ENSMUST00000154687 N/A 90.317±39.37 N/A N/A 9.014±3.90 25.027±13.10 N/A N/A N/A 24.818±3.97 N/A 25.970±5.12 N/A N/A
ENSMUST00000178812 N/A N/A 20.547±0.00 26.554±0.00 12.953±0.00 N/A N/A N/A N/A N/A 41.785±4.58 203.908±0.00 89.374±51.57 9.164±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000481 CIL_000481_0002 CGP 9:120929216-121277197

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000578 IDA embryonic axis specification
GO:0000904 IMP cell morphogenesis involved in differentiation
GO:0001102 IEA RNA polymerase II activating transcription factor binding
GO:0001501 IMP skeletal system development
GO:0001569 IMP patterning of blood vessels
GO:0001570 IMP vasculogenesis
GO:0001658 IMP branching involved in ureteric bud morphogenesis
GO:0001701 IMP in utero embryonic development
GO:0001702 IMP gastrulation with mouth forming second
GO:0001706 IMP endoderm formation
GO:0001708 IMP cell fate specification
GO:0001709 IMP cell fate determination
GO:0001711 IMP endodermal cell fate commitment
GO:0001764 IGI neuron migration
GO:0001822 IMP kidney development
GO:0001840 IDA neural plate development
GO:0001889 IBA liver development
GO:0001944 IMP vasculature development
GO:0002052 IGI positive regulation of neuroblast proliferation
GO:0002053 IMP positive regulation of mesenchymal cell proliferation
GO:0002089 IMP lens morphogenesis in camera-type eye
GO:0003136 IBA negative regulation of heart induction by canonical Wnt signaling pathway
GO:0003223 TAS ventricular compact myocardium morphogenesis
GO:0003266 IDA regulation of secondary heart field cardioblast proliferation
GO:0003337 IDA mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003338 IMP metanephros morphogenesis
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003690 IDA double-stranded DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003713 IDA transcription coactivator activity
GO:0005198 IBA structural molecule activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IDA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005813 IDA centrosome
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0005911 IDA cell-cell junction
GO:0005912 IDA adherens junction
GO:0005913 IDA cell-cell adherens junction
GO:0005915 IBA zonula adherens
GO:0005916 IDA fascia adherens
GO:0005923 IDA tight junction
GO:0005925 IEA focal adhesion
GO:0005938 ISS cell cortex
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006357 IMP regulation of transcription from RNA polymerase II promoter
GO:0007016 IBA cytoskeletal anchoring at plasma membrane
GO:0007155 ISS cell adhesion
GO:0007160 IMP cell-matrix adhesion
GO:0007268 IMP synaptic transmission
GO:0007398 IMP ectoderm development
GO:0007403 IDA glial cell fate determination
GO:0007494 IEA midgut development
GO:0007507 IMP heart development
GO:0008022 IEA protein C-terminus binding
GO:0008134 IPI transcription factor binding
GO:0008283 IMP cell proliferation
GO:0008284 IMP positive regulation of cell proliferation
GO:0008285 ISS negative regulation of cell proliferation
GO:0009725 IEA response to hormone
GO:0009898 IBA cytoplasmic side of plasma membrane
GO:0009948 IMP anterior/posterior axis specification
GO:0009950 IMP dorsal/ventral axis specification
GO:0009953 IMP dorsal/ventral pattern formation
GO:0009954 IMP proximal/distal pattern formation
GO:0009987 IDA cellular process
GO:0010468 IMP regulation of gene expression
GO:0010628 IMP positive regulation of gene expression
GO:0010718 TAS positive regulation of epithelial to mesenchymal transition
GO:0010909 ISS positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0014010 IBA Schwann cell proliferation
GO:0014070 IEA response to organic cyclic compound
GO:0014704 IDA intercalated disc
GO:0016020 IDA membrane
GO:0016055 IDA Wnt signaling pathway
GO:0016323 IDA basolateral plasma membrane
GO:0016328 IDA lateral plasma membrane
GO:0016331 IMP morphogenesis of embryonic epithelium
GO:0016337 IMP single organismal cell-cell adhesion
GO:0016342 IBA:ISS catenin complex
GO:0019899 IEA enzyme binding
GO:0019900 IEA kinase binding
GO:0019901 IBA protein kinase binding
GO:0019903 IPI protein phosphatase binding
GO:0021819 IMP layer formation in cerebral cortex
GO:0022009 IMP central nervous system vasculogenesis
GO:0022405 IMP hair cycle process
GO:0030018 IDA Z disc
GO:0030027 IDA lamellipodium
GO:0030054 ISS cell junction
GO:0030057 IBA desmosome
GO:0030097 IDA hemopoiesis
GO:0030154 IMP cell differentiation
GO:0030217 IMP T cell differentiation
GO:0030316 IMP osteoclast differentiation
GO:0030324 IMP lung development
GO:0030331 IEA estrogen receptor binding
GO:0030539 IMP male genitalia development
GO:0030856 IMP regulation of epithelial cell differentiation
GO:0030858 IMP positive regulation of epithelial cell differentiation
GO:0030877 IDA:ISS beta-catenin destruction complex
GO:0030900 IMP forebrain development
GO:0030902 IBA hindbrain development
GO:0030997 ISS regulation of centriole-centriole cohesion
GO:0031016 IMP pancreas development
GO:0031069 IMP hair follicle morphogenesis
GO:0031253 IDA cell projection membrane
GO:0031528 IDA microvillus membrane
GO:0031641 IMP regulation of myelination
GO:0032331 IGI negative regulation of chondrocyte differentiation
GO:0032355 ISS response to estradiol
GO:0032403 IEA protein complex binding
GO:0032993 ISS protein-DNA complex
GO:0033077 IMP T cell differentiation in thymus
GO:0033234 ISS negative regulation of protein sumoylation
GO:0034097 IEA response to cytokine
GO:0034332 IMP adherens junction organization
GO:0034333 ISS adherens junction assembly
GO:0034394 ISS protein localization to cell surface
GO:0034613 IMP cellular protein localization
GO:0034750 IDA Scrib-APC-beta-catenin complex
GO:0035050 IMP embryonic heart tube development
GO:0035112 IMP genitalia morphogenesis
GO:0035115 IDA embryonic forelimb morphogenesis
GO:0035116 IMP embryonic hindlimb morphogenesis
GO:0035255 IEA ionotropic glutamate receptor binding
GO:0035257 IPI nuclear hormone receptor binding
GO:0036023 IGI embryonic skeletal limb joint morphogenesis
GO:0042127 IDA regulation of cell proliferation
GO:0042129 IMP regulation of T cell proliferation
GO:0042475 IMP odontogenesis of dentin-containing tooth
GO:0042493 IEA response to drug
GO:0042733 IMP embryonic digit morphogenesis
GO:0042981 IMP regulation of apoptotic process
GO:0043005 IEA neuron projection
GO:0043065 ISS positive regulation of apoptotic process
GO:0043123 IMP positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043198 IBA dendritic shaft
GO:0043234 IEA protein complex
GO:0043296 IDA apical junction complex
GO:0043410 IGI positive regulation of MAPK cascade
GO:0043588 IMP skin development
GO:0043627 IBA response to estrogen
GO:0044212 IDA transcription regulatory region DNA binding
GO:0044325 IEA ion channel binding
GO:0044334 ISS canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0044336 IEA canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0045177 IDA apical part of cell
GO:0045202 IBA synapse
GO:0045294 IDA alpha-catenin binding
GO:0045296 ISO cadherin binding
GO:0045445 IEA myoblast differentiation
GO:0045453 IGI bone resorption
GO:0045595 IDA regulation of cell differentiation
GO:0045596 IMP negative regulation of cell differentiation
GO:0045603 IMP positive regulation of endothelial cell differentiation
GO:0045667 IMP regulation of osteoblast differentiation
GO:0045669 IMP positive regulation of osteoblast differentiation
GO:0045670 IMP regulation of osteoclast differentiation
GO:0045671 IMP negative regulation of osteoclast differentiation
GO:0045743 IMP positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IBA:ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046332 IEA SMAD binding
GO:0046686 IEA response to cadmium ion
GO:0048469 IMP cell maturation
GO:0048471 ISS perinuclear region of cytoplasm
GO:0048489 IMP synaptic vesicle transport
GO:0048513 IMP organ development
GO:0048538 IMP thymus development
GO:0048599 IGI oocyte development
GO:0048617 IMP embryonic foregut morphogenesis
GO:0048660 ISS regulation of smooth muscle cell proliferation
GO:0048715 IMP negative regulation of oligodendrocyte differentiation
GO:0050808 IMP synapse organization
GO:0050998 IEA nitric-oxide synthase binding
GO:0051145 IMP smooth muscle cell differentiation
GO:0051291 IEA protein heterooligomerization
GO:0060038 TAS cardiac muscle cell proliferation
GO:0060066 IMP oviduct development
GO:0060070 IDA canonical Wnt signaling pathway
GO:0060173 IMP limb development
GO:0060439 IMP trachea morphogenesis
GO:0060440 IMP trachea formation
GO:0060441 IMP epithelial tube branching involved in lung morphogenesis
GO:0060479 IMP lung cell differentiation
GO:0060484 IMP lung-associated mesenchyme development
GO:0060485 TAS mesenchyme development
GO:0060492 IMP lung induction
GO:0060742 IMP epithelial cell differentiation involved in prostate gland development
GO:0060769 IMP positive regulation of epithelial cell proliferation involved in prostate gland development
GO:0060789 IMP hair follicle placode formation
GO:0060916 IMP mesenchymal cell proliferation involved in lung development
GO:0060947 TAS cardiac vascular smooth muscle cell differentiation
GO:0060982 TAS coronary artery morphogenesis
GO:0060983 TAS epicardium-derived cardiac vascular smooth muscle cell differentiation
GO:0061047 IMP positive regulation of branching involved in lung morphogenesis
GO:0061154 ISS endothelial tube morphogenesis
GO:0061198 IMP fungiform papilla formation
GO:0061324 IMP canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
GO:0070062 IEA extracellular vesicular exosome
GO:0070369 ISS beta-catenin-TCF7L2 complex
GO:0070411 IEA I-SMAD binding
GO:0070412 IEA R-SMAD binding
GO:0070491 IPI repressing transcription factor binding
GO:0070602 IMP regulation of centromeric sister chromatid cohesion
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071363 ISS cellular response to growth factor stimulus
GO:0071407 IDA cellular response to organic cyclic compound
GO:0071664 IDA catenin-TCF7L2 complex
GO:0071681 ISS cellular response to indole-3-methanol
GO:0071944 ISS cell periphery
GO:0072001 IMP renal system development
GO:0072033 IMP renal vesicle formation
GO:0072053 IMP renal inner medulla development
GO:0072054 IMP renal outer medulla development
GO:0072079 IMP nephron tubule formation
GO:0072132 TAS mesenchyme morphogenesis
GO:0072182 IMP regulation of nephron tubule epithelial cell differentiation
GO:0090279 ISS regulation of calcium ion import
GO:1901215 IGI negative regulation of neuron death
GO:1990314 IEA cellular response to insulin-like growth factor stimulus
GO:2000008 ISS regulation of protein localization to cell surface
GO:2000017 IDA positive regulation of determination of dorsal identity
GO:2001234 IMP negative regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014571 ctnnb1 catenin (cadherin-associated protein), beta 1 protein_coding Danio_rerio
ENSG00000168036 CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa protein_coding Homo_sapiens

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