C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: catenin (cadherin-associated protein), beta 1, 88kDa
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000168036 CTNNB1 9606 + 3:41194837-41260096 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000349496 CTNNB1-001 41199439-41240453 protein_coding
  ENST00000396183 CTNNB1-003 41199434-41240443 protein_coding
  ENST00000396185 CTNNB1-002 41199505-41240443 protein_coding
  ENST00000405570 CTNNB1-007 41194910-41239353 protein_coding
  ENST00000426215 CTNNB1-010 41194837-41224711 protein_coding
  ENST00000431914 CTNNB1-012 41198645-41225161 protein_coding
  ENST00000433400 CTNNB1-011 41195198-41224551 protein_coding
  ENST00000441708 CTNNB1-014 41222086-41225012 protein_coding
  ENST00000450969 CTNNB1-013 41200111-41225038 protein_coding
  ENST00000453024 CTNNB1-005 41199445-41239736 protein_coding
  ENST00000465552 CTNNB1-016 41234154-41236962 retained_intron
  ENST00000471014 CTNNB1-017 41239133-41260096 processed_transcript
  ENST00000482042 CTNNB1-004 41235597-41237467 retained_intron
  ENST00000485265 CTNNB1-006 41235791-41237218 retained_intron
  ENST00000488914 CTNNB1-015 41224427-41225556 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000349496ENST00000396183ENST00000396185ENST00000405570ENST00000453024
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000349496 32.558±0.00 34.524±0.00 6.725±0.00 25.244±7.20 27.339±10.45 23.744±9.93 8.874±5.19 24.971±16.92 14.024±0.88 22.281±7.86 4.667±0.00 52.697±18.06 37.343±19.25 23.646±12.70
ENST00000396183 N/A N/A N/A N/A 5.511±0.00 N/A 5.816±2.98 N/A N/A N/A 3.638±1.79 16.150±4.84 10.682±1.29 N/A
ENST00000396185 25.977±0.00 23.070±0.00 7.754±0.00 17.313±2.99 19.033±1.75 16.268±0.10 10.934±5.22 18.390±0.35 13.779±3.69 28.294±8.68 5.665±1.24 32.041±2.88 29.198±10.15 18.417±5.83
ENST00000405570 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 8.805±0.00 N/A N/A N/A
ENST00000453024 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 6.201±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_000481 CIL_000481_0001 CGP 3:41194837-41962430

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IBA negative regulation of transcription from RNA polymerase II promoter
GO:0000578 IBA embryonic axis specification
GO:0000904 IEA cell morphogenesis involved in differentiation
GO:0001102 IPI RNA polymerase II activating transcription factor binding
GO:0001501 IEA skeletal system development
GO:0001569 IBA patterning of blood vessels
GO:0001570 IEA vasculogenesis
GO:0001658 IBA branching involved in ureteric bud morphogenesis
GO:0001701 IEA in utero embryonic development
GO:0001702 IBA gastrulation with mouth forming second
GO:0001706 IEA endoderm formation
GO:0001708 IEA cell fate specification
GO:0001709 IEA cell fate determination
GO:0001711 IBA endodermal cell fate commitment
GO:0001764 IEA neuron migration
GO:0001822 IEA kidney development
GO:0001837 TAS epithelial to mesenchymal transition
GO:0001840 IEA neural plate development
GO:0001889 IBA liver development
GO:0001944 IEA vasculature development
GO:0002052 IEA positive regulation of neuroblast proliferation
GO:0002053 IEA positive regulation of mesenchymal cell proliferation
GO:0002089 IEA lens morphogenesis in camera-type eye
GO:0003136 IBA negative regulation of heart induction by canonical Wnt signaling pathway
GO:0003266 IEA regulation of secondary heart field cardioblast proliferation
GO:0003337 IBA mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003338 IEA metanephros morphogenesis
GO:0003677 IEA DNA binding
GO:0003682 IEA chromatin binding
GO:0003690 IEA double-stranded DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0003713 IDA transcription coactivator activity
GO:0004871 NAS signal transducer activity
GO:0005198 IBA structural molecule activity
GO:0005488 IEA binding
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IDA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005813 IDA centrosome
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0005911 IDA cell-cell junction
GO:0005912 IDA adherens junction
GO:0005913 IDA cell-cell adherens junction
GO:0005915 IBA zonula adherens
GO:0005916 IBA fascia adherens
GO:0005923 IEA tight junction
GO:0005925 IDA focal adhesion
GO:0005938 IDA cell cortex
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006915 TAS apoptotic process
GO:0006921 TAS cellular component disassembly involved in execution phase of apoptosis
GO:0007016 IBA cytoskeletal anchoring at plasma membrane
GO:0007155 IMP cell adhesion
GO:0007160 IBA cell-matrix adhesion
GO:0007268 IEA synaptic transmission
GO:0007398 IBA ectoderm development
GO:0007403 IBA glial cell fate determination
GO:0007494 IEA midgut development
GO:0007507 IEA heart development
GO:0008022 IPI protein C-terminus binding
GO:0008134 TAS transcription factor binding
GO:0008283 IEA cell proliferation
GO:0008284 IEA positive regulation of cell proliferation
GO:0008285 IDA negative regulation of cell proliferation
GO:0009725 IEA response to hormone
GO:0009898 IBA cytoplasmic side of plasma membrane
GO:0009948 IEA anterior/posterior axis specification
GO:0009950 IBA dorsal/ventral axis specification
GO:0009953 IEA dorsal/ventral pattern formation
GO:0009954 IBA proximal/distal pattern formation
GO:0009987 IEA cellular process
GO:0010468 IEA regulation of gene expression
GO:0010628 IEA positive regulation of gene expression
GO:0010718 IGI positive regulation of epithelial to mesenchymal transition
GO:0010909 IMP positive regulation of heparan sulfate proteoglycan biosynthetic process
GO:0014010 IBA Schwann cell proliferation
GO:0014070 IEA response to organic cyclic compound
GO:0014704 IEA intercalated disc
GO:0016020 ISS membrane
GO:0016055 IDA Wnt signaling pathway
GO:0016323 IEA basolateral plasma membrane
GO:0016328 IDA lateral plasma membrane
GO:0016331 IEA morphogenesis of embryonic epithelium
GO:0016337 IMP single organismal cell-cell adhesion
GO:0016342 IDA catenin complex
GO:0019899 IPI enzyme binding
GO:0019900 IPI kinase binding
GO:0019901 IBA protein kinase binding
GO:0019903 IPI protein phosphatase binding
GO:0021819 IEA layer formation in cerebral cortex
GO:0022009 IBA central nervous system vasculogenesis
GO:0022405 IEA hair cycle process
GO:0030018 IBA Z disc
GO:0030027 IBA lamellipodium
GO:0030054 TAS cell junction
GO:0030057 IBA desmosome
GO:0030097 IEA hemopoiesis
GO:0030154 IEA cell differentiation
GO:0030217 IEA T cell differentiation
GO:0030316 IEA osteoclast differentiation
GO:0030324 IEA lung development
GO:0030326 IBA embryonic limb morphogenesis
GO:0030331 IPI estrogen receptor binding
GO:0030521 NAS androgen receptor signaling pathway
GO:0030539 IBA male genitalia development
GO:0030856 IEA regulation of epithelial cell differentiation
GO:0030858 IEA positive regulation of epithelial cell differentiation
GO:0030877 IDA beta-catenin destruction complex
GO:0030900 IEA forebrain development
GO:0030902 IBA hindbrain development
GO:0030997 IDA regulation of centriole-centriole cohesion
GO:0031016 IBA pancreas development
GO:0031069 IBA hair follicle morphogenesis
GO:0031253 IEA cell projection membrane
GO:0031528 IBA microvillus membrane
GO:0031641 IEA regulation of myelination
GO:0032331 IBA negative regulation of chondrocyte differentiation
GO:0032355 IDA response to estradiol
GO:0032403 IEA protein complex binding
GO:0032481 TAS positive regulation of type I interferon production
GO:0032993 IDA protein-DNA complex
GO:0033077 IBA T cell differentiation in thymus
GO:0033234 IDA negative regulation of protein sumoylation
GO:0034097 IEA response to cytokine
GO:0034332 IEA adherens junction organization
GO:0034333 IMP adherens junction assembly
GO:0034394 IMP protein localization to cell surface
GO:0034613 IEA cellular protein localization
GO:0034750 IEA Scrib-APC-beta-catenin complex
GO:0035050 IEA embryonic heart tube development
GO:0035112 IEA genitalia morphogenesis
GO:0035115 IEA embryonic forelimb morphogenesis
GO:0035116 IEA embryonic hindlimb morphogenesis
GO:0035255 IEA ionotropic glutamate receptor binding
GO:0035257 IPI nuclear hormone receptor binding
GO:0035315 TAS hair cell differentiation
GO:0036023 ISS embryonic skeletal limb joint morphogenesis
GO:0042127 IEA regulation of cell proliferation
GO:0042129 IBA regulation of T cell proliferation
GO:0042475 IBA odontogenesis of dentin-containing tooth
GO:0042493 IEP response to drug
GO:0042692 TAS muscle cell differentiation
GO:0042733 IEA embryonic digit morphogenesis
GO:0042981 IEA regulation of apoptotic process
GO:0043005 IEA neuron projection
GO:0043065 IDA positive regulation of apoptotic process
GO:0043123 IBA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043198 IBA dendritic shaft
GO:0043234 IEA protein complex
GO:0043296 IEA apical junction complex
GO:0043410 IBA positive regulation of MAPK cascade
GO:0043587 IBA tongue morphogenesis
GO:0043588 IEA skin development
GO:0043627 IEA response to estrogen
GO:0044212 IDA transcription regulatory region DNA binding
GO:0044325 IPI ion channel binding
GO:0044334 IMP canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition
GO:0044336 IMP canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0045087 TAS innate immune response
GO:0045177 IEA apical part of cell
GO:0045202 IBA synapse
GO:0045294 IPI alpha-catenin binding
GO:0045296 IPI cadherin binding
GO:0045445 IEA myoblast differentiation
GO:0045453 IEA bone resorption
GO:0045595 IEA regulation of cell differentiation
GO:0045596 IEA negative regulation of cell differentiation
GO:0045603 IEA positive regulation of endothelial cell differentiation
GO:0045667 IEA regulation of osteoblast differentiation
GO:0045669 IBA positive regulation of osteoblast differentiation
GO:0045670 IEA regulation of osteoclast differentiation
GO:0045671 IBA negative regulation of osteoclast differentiation
GO:0045743 IBA positive regulation of fibroblast growth factor receptor signaling pathway
GO:0045765 TAS regulation of angiogenesis
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046332 IPI SMAD binding
GO:0046686 IEA response to cadmium ion
GO:0048145 TAS regulation of fibroblast proliferation
GO:0048262 IBA determination of dorsal/ventral asymmetry
GO:0048469 IEA cell maturation
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048489 IBA synaptic vesicle transport
GO:0048513 IEA organ development
GO:0048538 IBA thymus development
GO:0048599 IBA oocyte development
GO:0048617 IBA embryonic foregut morphogenesis
GO:0048660 IMP regulation of smooth muscle cell proliferation
GO:0048715 IEA negative regulation of oligodendrocyte differentiation
GO:0050681 NAS androgen receptor binding
GO:0050808 IBA synapse organization
GO:0050998 IEA nitric-oxide synthase binding
GO:0051145 IBA smooth muscle cell differentiation
GO:0051149 TAS positive regulation of muscle cell differentiation
GO:0051291 IEA protein heterooligomerization
GO:0060066 IEA oviduct development
GO:0060070 IDA canonical Wnt signaling pathway
GO:0060173 IEA limb development
GO:0060439 IEA trachea morphogenesis
GO:0060440 IBA trachea formation
GO:0060441 IEA epithelial tube branching involved in lung morphogenesis
GO:0060479 IBA lung cell differentiation
GO:0060484 IBA lung-associated mesenchyme development
GO:0060492 IBA lung induction
GO:0060742 IEA epithelial cell differentiation involved in prostate gland development
GO:0060769 IBA positive regulation of epithelial cell proliferation involved in prostate gland development
GO:0060789 IBA hair follicle placode formation
GO:0060916 IBA mesenchymal cell proliferation involved in lung development
GO:0061047 IBA positive regulation of branching involved in lung morphogenesis
GO:0061154 IMP endothelial tube morphogenesis
GO:0061198 IEA fungiform papilla formation
GO:0061324 ISS canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation
GO:0070062 IDA extracellular vesicular exosome
GO:0070369 IDA beta-catenin-TCF7L2 complex
GO:0070411 IPI I-SMAD binding
GO:0070412 IPI R-SMAD binding
GO:0070491 IEA repressing transcription factor binding
GO:0070602 IMP regulation of centromeric sister chromatid cohesion
GO:0071260 IEA cellular response to mechanical stimulus
GO:0071363 IMP cellular response to growth factor stimulus
GO:0071407 IEA cellular response to organic cyclic compound
GO:0071664 IEA catenin-TCF7L2 complex
GO:0071681 IDA cellular response to indole-3-methanol
GO:0071944 IDA cell periphery
GO:0072001 IEA renal system development
GO:0072033 IBA renal vesicle formation
GO:0072053 IBA renal inner medulla development
GO:0072054 IBA renal outer medulla development
GO:0072079 IBA nephron tubule formation
GO:0072182 ISS regulation of nephron tubule epithelial cell differentiation
GO:0090279 IDA regulation of calcium ion import
GO:1901215 IEA negative regulation of neuron death
GO:1990314 IEA cellular response to insulin-like growth factor stimulus
GO:2000008 IDA regulation of protein localization to cell surface
GO:2000017 IEA positive regulation of determination of dorsal identity
GO:2001234 IEA negative regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014571 ctnnb1 catenin (cadherin-associated protein), beta 1 protein_coding Danio_rerio
ENSMUSG00000006932 Ctnnb1 catenin (cadherin associated protein), beta 1 protein_coding Mus_musculus

Loading