C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: twist basic helix-loop-helix transcription factor 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000007805 Twist2 10090 + 1:91801461-91848028 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000007949 Twist2-001 91801461-91848028 protein_coding
  ENSMUST00000186075 Twist2-002 91801470-91803994 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000007949ENSMUST00000186075
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000007949 36.512±29.38 5.342±0.64 10.932±0.58 6.267±3.59 17.670±7.68 3.357±0.57 1.536±0.64 0.841±0.23 0.203±0.22 5.292±0.31 0.242±0.14 16.742±8.91 1.610±1.30 0.299±0.23
ENSMUST00000186075 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.020±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003NF CIL_0003NF_0002 CGP 1:91540544-91848028
CIL_0007UT CIL_0007UT_0002 VISTA 1:91662928-92265960
CIL_0003NG CIL_0003NG_0002 CGP 1:91801461-92180341

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IGI negative regulation of transcription from RNA polymerase II promoter
GO:0001076 IDA RNA polymerase II transcription factor binding transcription factor activity
GO:0001649 IMP osteoblast differentiation
GO:0003682 IDA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005667 IPI transcription factor complex
GO:0005737 IEA cytoplasm
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0008285 IMP negative regulation of cell proliferation
GO:0010838 IMP positive regulation of keratinocyte proliferation
GO:0019904 IPI protein domain specific binding
GO:0032720 IGI negative regulation of tumor necrosis factor production
GO:0043066 IEA negative regulation of apoptotic process
GO:0043392 IDA negative regulation of DNA binding
GO:0044092 IDA negative regulation of molecular function
GO:0045638 IMP negative regulation of myeloid cell differentiation
GO:0045668 IMP negative regulation of osteoblast differentiation
GO:0046983 IEA protein dimerization activity
GO:0048701 IGI embryonic cranial skeleton morphogenesis
GO:0060325 IMP face morphogenesis
GO:0061303 IMP cornea development in camera-type eye

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000031277 twist1b twist1b protein_coding Danio_rerio
ENSDARG00000076010 twist1b twist1b protein_coding Danio_rerio
ENSG00000233608 TWIST2 twist family bHLH transcription factor 2 protein_coding Homo_sapiens

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