C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: sirtuin 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000170068 Sirt2-201 ENSMUSG00000015149 10090 + 7:28766752-28788665 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; BreastENSMUST00000170068
Transcript ID Breast
ENSMUST00000170068 13.387±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006UY CIL_0006UY_0002 CGP 7:28766735-28798963

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000122 ISS negative regulation of transcription from RNA polymerase II promoter
GO:0003682 ISS chromatin binding
GO:0004407 ISS histone deacetylase activity
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005694 ISS chromosome
GO:0005720 ISS nuclear heterochromatin
GO:0005737 ISS cytoplasm
GO:0005813 ISS centrosome
GO:0005814 ISS centriole
GO:0005819 ISS spindle
GO:0005829 ISS cytosol
GO:0005874 ISS microtubule
GO:0005886 IEA plasma membrane
GO:0006351 IEA transcription, DNA-templated
GO:0006476 IMP protein deacetylation
GO:0006914 IEA autophagy
GO:0007067 IEA mitotic nuclear division
GO:0008134 ISS transcription factor binding
GO:0008285 ISS negative regulation of cell proliferation
GO:0010507 ISS negative regulation of autophagy
GO:0010801 IMP negative regulation of peptidyl-threonine phosphorylation
GO:0014065 ISS phosphatidylinositol 3-kinase signaling
GO:0016575 IGI histone deacetylation
GO:0017136 ISS NAD-dependent histone deacetylase activity
GO:0022011 IMP myelination in peripheral nervous system
GO:0030496 ISS midbody
GO:0031641 IMP regulation of myelination
GO:0032436 IMP positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033010 IDA paranodal junction
GO:0033270 ISS paranode region of axon
GO:0033558 IMP protein deacetylase activity
GO:0034599 IDA cellular response to oxidative stress
GO:0034979 ISS NAD-dependent protein deacetylase activity
GO:0034983 ISS peptidyl-lysine deacetylation
GO:0035035 ISS histone acetyltransferase binding
GO:0035729 ISS cellular response to hepatocyte growth factor stimulus
GO:0042177 ISS negative regulation of protein catabolic process
GO:0042826 ISS histone deacetylase binding
GO:0042903 ISS tubulin deacetylase activity
GO:0043130 ISS ubiquitin binding
GO:0043161 ISS proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043204 IDA perikaryon
GO:0043209 IDA myelin sheath
GO:0043219 ISS lateral loop
GO:0043220 IDA Schmidt-Lanterman incisure
GO:0043388 IDA positive regulation of DNA binding
GO:0043491 ISS protein kinase B signaling
GO:0044224 ISS juxtaparanode region of axon
GO:0044242 IMP cellular lipid catabolic process
GO:0045598 IMP regulation of fat cell differentiation
GO:0045599 IMP negative regulation of fat cell differentiation
GO:0045836 IMP positive regulation of meiosis
GO:0045843 ISS negative regulation of striated muscle tissue development
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0045944 IMP positive regulation of transcription from RNA polymerase II promoter
GO:0046970 ISS NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0048012 ISS hepatocyte growth factor receptor signaling pathway
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048487 IDA beta-tubulin binding
GO:0051321 IEA meiotic cell cycle
GO:0051726 ISS regulation of cell cycle
GO:0051781 IMP positive regulation of cell division
GO:0051987 IMP positive regulation of attachment of spindle microtubules to kinetochore
GO:0061428 ISS negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061433 IDA cellular response to caloric restriction
GO:0070403 IEA NAD+ binding
GO:0070446 ISS negative regulation of oligodendrocyte progenitor proliferation
GO:0070932 IMP histone H3 deacetylation
GO:0070933 ISS histone H4 deacetylation
GO:0071219 ISS cellular response to molecule of bacterial origin
GO:0071456 ISS cellular response to hypoxia
GO:0071872 IDA cellular response to epinephrine stimulus
GO:0072686 ISS mitotic spindle
GO:0072687 IDA meiotic spindle
GO:0090042 IGI tubulin deacetylation
GO:0097386 ISS glial cell projection
GO:1900119 IMP positive regulation of execution phase of apoptosis
GO:1900195 IMP positive regulation of oocyte maturation
GO:1900226 IMP negative regulation of NLRP3 inflammasome complex assembly
GO:1900425 IMP negative regulation of defense response to bacterium
GO:1901026 IMP ripoptosome assembly involved in necroptotic process
GO:2000378 IMP negative regulation of reactive oxygen species metabolic process
GO:2000777 ISS positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000249396 SIRT2-001 protein_coding Homo_sapiens 0 1003
ENST00000358931 SIRT2-201 protein_coding Homo_sapiens 0 617
ENST00000381766 SIRT2-016 protein_coding Homo_sapiens 0 361
ENST00000392081 SIRT2-002 protein_coding Homo_sapiens 0 1003
ENST00000407552 SIRT2-005 protein_coding Homo_sapiens 0 451
ENST00000414941 SIRT2-008 protein_coding Homo_sapiens 0 664
ENST00000420440 SIRT2-010 nonsense_mediated_decay Homo_sapiens 0 261
ENST00000423526 SIRT2-012 nonsense_mediated_decay Homo_sapiens 8.99998e-41 171
ENST00000437828 SIRT2-007 protein_coding Homo_sapiens 0.0000002 60
ENST00000443898 SIRT2-009 nonsense_mediated_decay Homo_sapiens 0 507
ENST00000447739 SIRT2-006 protein_coding Homo_sapiens 0.000000000002 77
ENST00000451193 SIRT2-011 nonsense_mediated_decay Homo_sapiens 0 246
ENST00000462654 SIRT2-003 retained_intron Homo_sapiens 0 1003
ENST00000476771 SIRT2-013 retained_intron Homo_sapiens 5.99756e-43 178
ENST00000479290 SIRT2-004 retained_intron Homo_sapiens 2e-26 126
ENST00000491960 SIRT2-014 retained_intron Homo_sapiens 0 261
ENST00000613542 SIRT2-202 protein_coding Homo_sapiens 0 990
ENST00000620437 SIRT2-203 protein_coding Homo_sapiens 0 1050

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