C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: epidermal growth factor receptor pathway substrate 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000015766 Eps8 10090 - 6:137477245-137654876 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000058210 Eps8-001 137477245-137649285 protein_coding
  ENSMUST00000100841 Eps8-004 137477668-137571017 protein_coding
  ENSMUST00000111878 Eps8-002 137478177-137649285 protein_coding
  ENSMUST00000127179 Eps8-011 137514340-137519760 processed_transcript
  ENSMUST00000130274 Eps8-005 137478133-137519895 processed_transcript
  ENSMUST00000132920 Eps8-010 137517071-137654876 protein_coding
  ENSMUST00000134630 Eps8-006 137539337-137649242 protein_coding
  ENSMUST00000139753 Eps8-013 137537638-137648283 processed_transcript
  ENSMUST00000146442 Eps8-009 137522862-137589026 protein_coding
  ENSMUST00000147526 Eps8-003 137499639-137648283 protein_coding
  ENSMUST00000152046 Eps8-012 137517095-137519703 processed_transcript
  ENSMUST00000153933 Eps8-008 137527395-137649229 processed_transcript
  ENSMUST00000156916 Eps8-007 137572190-137649200 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000058210ENSMUST00000100841ENSMUST00000111878ENSMUST00000130274ENSMUST00000132920ENSMUST00000134630ENSMUST00000146442ENSMUST00000147526ENSMUST00000153933ENSMUST00000156916
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000058210 1.415±0.44 4.174±0.80 2.145±1.07 0.876±0.24 3.282±1.39 8.167±1.46 1.499±0.35 4.059±0.45 0.207±0.13 5.649±1.39 0.284±0.13 5.578±2.86 2.037±0.65 1.662±0.17
ENSMUST00000100841 2.717±0.94 1.999±0.00 1.734±0.36 0.555±0.21 1.565±0.53 13.039±2.12 0.773±0.26 16.511±1.85 0.162±0.08 N/A 0.372±0.21 3.354±1.16 5.363±3.21 N/A
ENSMUST00000111878 1.263±0.16 3.706±0.00 N/A 2.442±1.37 2.938±1.22 11.270±4.38 0.962±0.00 N/A 0.171±0.07 3.848±1.49 0.244±0.08 2.759±0.68 4.111±1.43 1.216±0.49
ENSMUST00000130274 2.075±0.01 4.766±0.00 N/A N/A 2.484±0.11 16.563±0.94 1.186±0.39 10.526±0.31 0.349±0.05 N/A N/A 5.355±1.74 0.904±0.00 0.849±0.18
ENSMUST00000132920 N/A N/A N/A N/A N/A N/A N/A N/A 0.327±0.00 N/A N/A N/A N/A N/A
ENSMUST00000134630 N/A 14.642±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000146442 N/A N/A N/A 16.799±0.00 N/A N/A N/A N/A N/A N/A N/A 20.308±0.00 31.585±13.10 N/A
ENSMUST00000147526 1.760±0.45 4.713±0.00 N/A N/A 4.089±0.23 18.919±4.63 N/A 10.215±1.26 0.297±0.12 4.493±0.80 N/A 7.238±2.55 N/A 1.458±0.31
ENSMUST00000153933 11.386±0.42 29.895±11.69 N/A 19.168±0.00 20.557±7.41 N/A N/A N/A 1.049±0.09 23.041±10.19 N/A 28.365±10.56 36.450±16.41 N/A
ENSMUST00000156916 N/A 34.875±10.47 N/A N/A N/A N/A N/A N/A 1.187±0.14 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005VB CIL_0005VB_0003 CGP 6:137252299-137654876
CIL_0007F9 CIL_0007F9_0002 CGP 6:137477245-137751932

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003779 IDA actin binding
GO:0005515 IPI protein binding
GO:0005938 IDA cell cortex
GO:0008344 IMP adult locomotory behavior
GO:0008360 IMP regulation of cell shape
GO:0010458 IMP exit from mitosis
GO:0014069 IDA postsynaptic density
GO:0016601 IDA Rac protein signal transduction
GO:0017146 IDA N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054 IEA cell junction
GO:0030832 IMP regulation of actin filament length
GO:0031532 IMP actin cytoskeleton reorganization
GO:0031982 IEA vesicle
GO:0032420 IDA stereocilium
GO:0032587 IDA ruffle membrane
GO:0036336 IMP dendritic cell migration
GO:0043005 IEA neuron projection
GO:0045202 IDA synapse
GO:0048149 IMP behavioral response to ethanol
GO:0048365 IDA Rac GTPase binding
GO:0051016 IDA barbed-end actin filament capping
GO:0051017 IGI:IMP actin filament bundle assembly
GO:0051764 IMP actin crosslink formation
GO:0070062 IEA extracellular vesicular exosome
GO:0070358 IDA actin polymerization-dependent cell motility

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018440 eps8 epidermal growth factor receptor pathway substrate 8 protein_coding Danio_rerio
ENSG00000151491 EPS8 epidermal growth factor receptor pathway substrate 8 protein_coding Homo_sapiens

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