C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: epidermal growth factor receptor pathway substrate 8
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000151491 EPS8 9606 - 12:15620158-15882329 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000281172 EPS8-001 15620162-15789576 protein_coding
  ENST00000508018 EPS8-016 15665349-15669467 retained_intron
  ENST00000535734 EPS8-013 15657894-15662115 retained_intron
  ENST00000535752 EPS8-017 15669668-15882329 protein_coding
  ENST00000536793 EPS8-009 15670856-15789388 protein_coding
  ENST00000536956 EPS8-011 15669466-15789400 nonsense_mediated_decay
  ENST00000540613 EPS8-005 15621203-15662692 protein_coding
  ENST00000541465 EPS8-014 15647150-15654430 retained_intron
  ENST00000542903 EPS8-006 15621274-15662274 protein_coding
  ENST00000543363 EPS8-007 15670856-15780727 protein_coding
  ENST00000543468 EPS8-002 15620158-15789370 nonsense_mediated_decay
  ENST00000543523 EPS8-003 15620158-15789388 protein_coding
  ENST00000543612 EPS8-004 15620983-15712993 protein_coding
  ENST00000544064 EPS8-010 15670859-15789381 protein_coding
  ENST00000545610 EPS8-015 15623220-15631762 retained_intron
  ENST00000546261 EPS8-012 15658076-15666505 nonsense_mediated_decay
  ENST00000546311 EPS8-008 15669519-15728265 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000281172ENST00000540613ENST00000542903ENST00000543612
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000281172 43.524±0.00 10.512±0.00 4.067±0.00 3.842±2.37 11.708±5.26 11.607±7.32 3.666±2.71 7.967±5.55 10.235±5.89 6.116±0.92 1.655±1.44 11.548±3.12 10.373±3.58 6.681±0.00
ENST00000540613 N/A N/A N/A 0.613±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000542903 N/A N/A N/A N/A N/A N/A 3.030±0.00 N/A N/A 3.635±0.00 1.917±0.00 24.379±0.00 10.834±0.00 6.516±0.00
ENST00000543612 N/A N/A N/A N/A N/A 2.216±0.00 0.616±0.00 1.301±0.00 N/A 2.819±0.00 N/A 8.013±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0005VB CIL_0005VB_0002 CGP 12:15322397-15882329
CIL_0007F9 CIL_0007F9_0001 CGP 12:15620158-15903478

Gene Ontology
GO IDEvidence TypeGO Description
GO:0003779 ISS actin binding
GO:0005070 TAS SH3/SH2 adaptor activity
GO:0005515 IPI:IEA protein binding
GO:0005938 ISS cell cortex
GO:0007165 TAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0008283 TAS cell proliferation
GO:0008344 IEA adult locomotory behavior
GO:0008360 ISS regulation of cell shape
GO:0009967 TAS positive regulation of signal transduction
GO:0010458 ISS exit from mitosis
GO:0014069 IEA postsynaptic density
GO:0016601 ISS Rac protein signal transduction
GO:0017146 IEA N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054 IEA cell junction
GO:0030832 ISS regulation of actin filament length
GO:0031532 IEA actin cytoskeleton reorganization
GO:0031982 IDA vesicle
GO:0032420 ISS stereocilium
GO:0032587 ISS ruffle membrane
GO:0036336 ISS dendritic cell migration
GO:0043005 IEA neuron projection
GO:0045202 IEA synapse
GO:0048149 IEA behavioral response to ethanol
GO:0048365 ISS Rac GTPase binding
GO:0051016 ISS barbed-end actin filament capping
GO:0051017 ISS actin filament bundle assembly
GO:0051764 ISS actin crosslink formation
GO:0070062 IDA extracellular vesicular exosome
GO:0070358 ISS actin polymerization-dependent cell motility

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000018440 eps8 epidermal growth factor receptor pathway substrate 8 protein_coding Danio_rerio
ENSMUSG00000015766 Eps8 epidermal growth factor receptor pathway substrate 8 protein_coding Mus_musculus

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