C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: CD40 antigen
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000017652 Cd40 10090 + 2:165055627-165072948 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000017799 Cd40-001 165055627-165072948 protein_coding
  ENSMUST00000073707 Cd40-201 165055636-165071654 protein_coding
  ENSMUST00000081310 Cd40-005 165055680-165070745 protein_coding
  ENSMUST00000140951 Cd40-003 165055681-165062780 protein_coding
  ENSMUST00000153105 Cd40-006 165062676-165066695 retained_intron
  ENSMUST00000154443 Cd40-004 165055627-165062723 nonsense_mediated_decay
  ENSMUST00000184221 Cd40-002 165055704-165071000 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000017799ENSMUST00000073707ENSMUST00000081310ENSMUST00000140951ENSMUST00000153105ENSMUST00000154443ENSMUST00000184221
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000017799 0.304±0.14 0.178±0.03 0.243±0.04 0.163±0.06 0.675±0.00 0.258±0.09 0.195±0.00 0.232±0.05 0.116±0.05 N/A 0.107±0.00 0.137±0.05 0.098±0.01 0.064±0.02
ENSMUST00000073707 0.985±0.30 0.852±0.29 1.096±0.05 0.788±0.06 6.363±2.10 0.573±0.23 0.451±0.22 1.002±0.34 0.559±0.25 5.327±1.17 0.129±0.05 0.928±0.55 0.538±0.21 0.049±0.00
ENSMUST00000081310 1.792±0.26 0.889±0.21 N/A 1.664±0.00 10.611±3.09 1.030±0.25 1.161±0.37 1.697±0.42 0.650±0.37 7.103±0.00 0.170±0.06 0.935±0.30 0.571±0.00 0.196±0.09
ENSMUST00000140951 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.184±0.00 N/A N/A N/A
ENSMUST00000153105 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.730±0.26 0.751±0.00 0.194±0.04
ENSMUST00000154443 N/A 1.491±0.17 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000184221 N/A N/A 0.950±0.12 0.345±0.19 N/A N/A 0.453±0.08 0.743±0.24 0.224±0.12 N/A 0.159±0.11 0.418±0.09 0.320±0.13 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007BI CIL_0007BI_0002 CGP 2:165000357-165072948

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001934 IEA positive regulation of protein phosphorylation
GO:0002768 IDA immune response-regulating cell surface receptor signaling pathway
GO:0003823 IEA antigen binding
GO:0005515 IPI protein binding
GO:0005615 IEA extracellular space
GO:0005737 IEA cytoplasm
GO:0005886 IDA plasma membrane
GO:0006874 IMP cellular calcium ion homeostasis
GO:0006954 IEA inflammatory response
GO:0009897 IDA external side of plasma membrane
GO:0009986 IDA cell surface
GO:0019899 IEA enzyme binding
GO:0030890 IDA positive regulation of B cell proliferation
GO:0031625 IEA ubiquitin protein ligase binding
GO:0032735 IDA positive regulation of interleukin-12 production
GO:0032855 IEA positive regulation of Rac GTPase activity
GO:0035631 IDA CD40 receptor complex
GO:0042113 IDA B cell activation
GO:0042511 IEA positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0043089 IEA positive regulation of Cdc42 GTPase activity
GO:0043123 IEA positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0043406 IEA positive regulation of MAP kinase activity
GO:0043491 IDA protein kinase B signaling
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0048304 IDA positive regulation of isotype switching to IgG isotypes
GO:0050776 IDA regulation of immune response
GO:0051023 IDA regulation of immunoglobulin secretion
GO:0051092 IEA positive regulation of NF-kappaB transcription factor activity
GO:0051607 IDA defense response to virus
GO:0070062 IEA extracellular vesicular exosome
GO:0071222 IEA cellular response to lipopolysaccharide
GO:0071260 IEA cellular response to mechanical stimulus
GO:0090037 IEA positive regulation of protein kinase C signaling
GO:2000353 IEA positive regulation of endothelial cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSG00000101017 CD40 CD40 molecule, TNF receptor superfamily member 5 protein_coding Homo_sapiens

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