C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: growth factor receptor bound protein 10
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020176 Grb10 10090 - 11:11930508-12038683 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000093321 Grb10-005 11930508-12037401 protein_coding
  ENSMUST00000109653 Grb10-004 11933094-11970642 protein_coding
  ENSMUST00000109654 Grb10-009 11930508-12027971 protein_coding
  ENSMUST00000124587 Grb10-008 11936718-11938616 processed_transcript
  ENSMUST00000142877 Grb10-006 11949600-11956024 processed_transcript
  ENSMUST00000143386 Grb10-003 11954744-12038683 protein_coding
  ENSMUST00000143915 Grb10-002 11967626-12026732 protein_coding
  ENSMUST00000148254 Grb10-007 11944890-11946330 processed_transcript
  ENSMUST00000150972 Grb10-001 11967532-12026324 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000093321ENSMUST00000109653ENSMUST00000109654
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000093321 30.462±7.20 19.235±5.05 10.578±0.31 43.319±7.85 12.270±2.61 3.544±1.40 12.446±1.48 7.683±2.81 60.214±68.71 14.134±2.90 4.949±1.18 16.659±6.52 33.547±23.61 4.408±0.90
ENSMUST00000109653 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.873±0.00
ENSMUST00000109654 4.864±0.00 N/A N/A N/A N/A N/A 2.061±0.00 2.021±0.00 N/A N/A 0.976±0.26 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008P3 CIL_0008P3_0002 VISTA 11:11375621-11977027
CIL_0008XT CIL_0008XT_0002 VISTA 11:11399170-12000205
CIL_0007SD CIL_0007SD_0002 VISTA 11:11453227-12053958
CIL_00089U CIL_00089U_0002 VISTA 11:11536402-12137998
CIL_0008KL CIL_0008KL_0002 VISTA 11:11661856-12262621
CIL_0004WV CIL_0004WV_0003 CGP 11:11814101-12038683
CIL_00072I CIL_00072I_0003 CGP 11:11930508-12464960

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001784 TAS phosphotyrosine binding
GO:0005070 IDA:IPI SH3/SH2 adaptor activity
GO:0005158 IPI insulin receptor binding
GO:0005515 IPI protein binding
GO:0005829 TAS cytosol
GO:0007165 TAS signal transduction
GO:0008286 IEA insulin receptor signaling pathway
GO:0009967 IDA positive regulation of signal transduction
GO:0030178 IDA negative regulation of Wnt signaling pathway
GO:0030949 ISS positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032868 IEA response to insulin
GO:0042326 IDA negative regulation of phosphorylation
GO:0042327 IEA positive regulation of phosphorylation
GO:0045719 TAS negative regulation of glycogen biosynthetic process
GO:0046325 IMP negative regulation of glucose import
GO:0046627 IMP negative regulation of insulin receptor signaling pathway
GO:0048009 IPI insulin-like growth factor receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000002013 grb10a growth factor receptor-bound protein 10a protein_coding Danio_rerio
ENSDARG00000035308 grb10b growth factor receptor-bound protein 10b protein_coding Danio_rerio
ENSG00000106070 GRB10 growth factor receptor-bound protein 10 protein_coding Homo_sapiens

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