C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: interleukin-1 receptor-associated kinase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020227 Irak3 10090 - 10:120141648-120202130 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000020448 Irak3-001 120141648-120201659 protein_coding
  ENSMUST00000135106 Irak3-004 120142163-120201498 nonsense_mediated_decay
  ENSMUST00000140237 Irak3-005 120160142-120170378 processed_transcript
  ENSMUST00000143100 Irak3-003 120164976-120201587 retained_intron
  ENSMUST00000145665 Irak3-002 120141665-120202130 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBreastLiverLungMuscleTestisENSMUST00000020448ENSMUST00000145665
Transcript ID Adipose Bladder Breast Liver Lung Muscle Testis
ENSMUST00000020448 4.569±0.96 2.920±0.15 5.541±0.69 2.081±0.00 3.040±0.41 0.838±0.07 N/A
ENSMUST00000145665 N/A N/A 9.325±0.00 N/A N/A N/A 11.522±1.99

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006WI CIL_0006WI_0002 CGP 10:120083608-120202130

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IDA magnesium ion binding
GO:0001960 IC negative regulation of cytokine-mediated signaling pathway
GO:0004672 IDA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IDA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0006468 IDA protein phosphorylation
GO:0006915 RCA apoptotic process
GO:0009615 IC response to virus
GO:0010933 IMP positive regulation of macrophage tolerance induction
GO:0010936 IMP negative regulation of macrophage cytokine production
GO:0019221 IDA cytokine-mediated signaling pathway
GO:0032088 IEA negative regulation of NF-kappaB transcription factor activity
GO:0032494 IMP response to peptidoglycan
GO:0032496 IMP response to lipopolysaccharide
GO:0032695 IMP negative regulation of interleukin-12 production
GO:0032715 IMP negative regulation of interleukin-6 production
GO:0032720 IMP negative regulation of tumor necrosis factor production
GO:0034122 IMP negative regulation of toll-like receptor signaling pathway
GO:0042177 IMP negative regulation of protein catabolic process
GO:0042803 IEA protein homodimerization activity
GO:0042981 RCA regulation of apoptotic process
GO:0043242 IEA negative regulation of protein complex disassembly
GO:0043244 IDA regulation of protein complex disassembly
GO:0043330 IMP response to exogenous dsRNA
GO:0043407 IMP negative regulation of MAP kinase activity
GO:0045824 IMP negative regulation of innate immune response
GO:0046777 IDA protein autophosphorylation
GO:0046982 IEA protein heterodimerization activity
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0070498 IDA interleukin-1-mediated signaling pathway
GO:0070555 IEA response to interleukin-1

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000053131 irak3 interleukin-1 receptor-associated kinase 3 protein_coding Danio_rerio
ENSG00000090376 IRAK3 interleukin-1 receptor-associated kinase 3 protein_coding Homo_sapiens

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