C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: interleukin-1 receptor-associated kinase 3
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000020448 Irak3-001 ENSMUSG00000020227 10090 - 10:120141648-120201659 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBreastLiverLungMuscleENSMUST00000020448
Transcript ID Adipose Bladder Breast Liver Lung Muscle
ENSMUST00000020448 4.569±0.96 2.920±0.15 5.541±0.69 2.081±0.00 3.040±0.41 0.838±0.07

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006WI CIL_0006WI_0002 CGP 10:120083608-120202130

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000287 IDA magnesium ion binding
GO:0001960 IC negative regulation of cytokine-mediated signaling pathway
GO:0004672 IDA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IDA ATP binding
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0006468 IDA protein phosphorylation
GO:0006915 RCA apoptotic process
GO:0009615 IC response to virus
GO:0010933 IMP positive regulation of macrophage tolerance induction
GO:0010936 IMP negative regulation of macrophage cytokine production
GO:0019221 IDA cytokine-mediated signaling pathway
GO:0032088 IEA negative regulation of NF-kappaB transcription factor activity
GO:0032494 IMP response to peptidoglycan
GO:0032496 IMP response to lipopolysaccharide
GO:0032695 IMP negative regulation of interleukin-12 production
GO:0032715 IMP negative regulation of interleukin-6 production
GO:0032720 IMP negative regulation of tumor necrosis factor production
GO:0034122 IMP negative regulation of toll-like receptor signaling pathway
GO:0042177 IMP negative regulation of protein catabolic process
GO:0042803 IEA protein homodimerization activity
GO:0042981 RCA regulation of apoptotic process
GO:0043242 IEA negative regulation of protein complex disassembly
GO:0043244 IDA regulation of protein complex disassembly
GO:0043330 IMP response to exogenous dsRNA
GO:0043407 IMP negative regulation of MAP kinase activity
GO:0045824 IMP negative regulation of innate immune response
GO:0046777 IDA protein autophosphorylation
GO:0046982 IEA protein heterodimerization activity
GO:0051092 IDA positive regulation of NF-kappaB transcription factor activity
GO:0070498 IDA interleukin-1-mediated signaling pathway
GO:0070555 IEA response to interleukin-1

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000261233 IRAK3-001 protein_coding Homo_sapiens 0 351

Loading