C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: myocardin
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020542 Myocd 10090 - 11:65176561-65269989 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000101042 Myocd-002 65178428-65218559 protein_coding
  ENSMUST00000102635 Myocd-001 65176561-65269941 protein_coding
  ENSMUST00000108695 Myocd-201 65176574-65269989 protein_coding
  ENSMUST00000144399 Myocd-005 65196102-65205467 protein_coding
  ENSMUST00000150823 Myocd-004 65223734-65269854 processed_transcript
  ENSMUST00000151483 Myocd-003 65176773-65182157 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000101042ENSMUST00000102635ENSMUST00000108695ENSMUST00000144399ENSMUST00000150823ENSMUST00000151483
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000101042 0.143±0.00 0.120±0.04 0.028±0.00 0.152±0.10 2.358±0.42 5.216±1.45 0.171±0.06 0.026±0.01 0.538±0.23 0.018±0.01 3.709±0.68 N/A 0.083±0.03
ENSMUST00000102635 N/A 0.040±0.00 0.006±0.00 0.224±0.10 N/A N/A N/A 0.020±0.01 0.119±0.00 0.070±0.03 0.952±0.00 0.042±0.03 0.018±0.00
ENSMUST00000108695 0.140±0.00 0.069±0.02 0.014±0.00 0.039±0.00 0.722±0.30 4.498±0.00 0.082±0.03 0.025±0.02 0.438±0.24 0.044±0.00 1.776±0.74 0.170±0.02 0.135±0.06
ENSMUST00000144399 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.179±0.00 N/A
ENSMUST00000150823 N/A N/A N/A N/A N/A N/A N/A 0.116±0.00 N/A N/A N/A N/A N/A
ENSMUST00000151483 N/A 0.078±0.01 0.008±0.00 N/A N/A N/A 0.035±0.00 0.012±0.01 N/A 0.031±0.01 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008DU CIL_0008DU_0002 VISTA 11:64598596-65200939
CIL_0008QC CIL_0008QC_0002 VISTA 11:64908855-65510457
CIL_0007YN CIL_0007YN_0002 VISTA 11:65135465-65736246

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IGI negative regulation of transcription from RNA polymerase II promoter
GO:0001046 IEA core promoter sequence-specific DNA binding
GO:0001076 IDA RNA polymerase II transcription factor binding transcription factor activity
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001560 IDA regulation of cell growth by extracellular stimulus
GO:0001570 IMP vasculogenesis
GO:0001666 IEA response to hypoxia
GO:0003231 IMP cardiac ventricle development
GO:0003257 IEA positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0003713 IDA transcription coactivator activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0007507 IMP heart development
GO:0008134 IEA transcription factor binding
GO:0008284 IDA positive regulation of cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0010667 IMP negative regulation of cardiac muscle cell apoptotic process
GO:0010832 IMP negative regulation of myotube differentiation
GO:0030511 IDA positive regulation of transforming growth factor beta receptor signaling pathway
GO:0035035 IPI histone acetyltransferase binding
GO:0035065 IDA regulation of histone acetylation
GO:0035733 IEA hepatic stellate cell activation
GO:0042692 IMP muscle cell differentiation
GO:0042826 IPI histone deacetylase binding
GO:0043388 IGI positive regulation of DNA binding
GO:0043954 IMP cellular component maintenance
GO:0045661 IMP regulation of myoblast differentiation
GO:0045736 IEA negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0045987 IEA positive regulation of smooth muscle contraction
GO:0048286 IMP lung alveolus development
GO:0048565 IMP digestive tract development
GO:0051091 IEA positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051145 IMP smooth muscle cell differentiation
GO:0051150 IEA regulation of smooth muscle cell differentiation
GO:0051152 IEA positive regulation of smooth muscle cell differentiation
GO:0055007 IMP cardiac muscle cell differentiation
GO:0055012 IMP ventricular cardiac muscle cell differentiation
GO:0060065 IMP uterus development
GO:0060157 IMP urinary bladder development
GO:0061049 IEA cell growth involved in cardiac muscle cell development
GO:0070412 IPI R-SMAD binding
GO:0070514 IC SRF-myogenin-E12 complex
GO:0071363 IEA cellular response to growth factor stimulus
GO:0071456 IEA cellular response to hypoxia
GO:0097070 IMP ductus arteriosus closure
GO:1900222 IEA negative regulation of beta-amyloid clearance
GO:2000721 IEA positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
GO:2000724 IEA positive regulation of cardiac vascular smooth muscle cell differentiation
GO:2000727 IEA positive regulation of cardiac muscle cell differentiation
GO:2001015 IEA negative regulation of skeletal muscle cell differentiation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000076267 MYOCD myocardin protein_coding Danio_rerio
ENSG00000141052 MYOCD myocardin protein_coding Homo_sapiens

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