C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: ring finger and FYVE like domain containing protein
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000020696 Rffl 10090 - 11:82802449-82871210 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000021036 Rffl-003 82805607-82829031 protein_coding
  ENSMUST00000071152 Rffl-201 82803822-82871210 protein_coding
  ENSMUST00000074515 Rffl-001 82802449-82829043 protein_coding
  ENSMUST00000093975 Rffl-202 82803822-82870744 protein_coding
  ENSMUST00000103218 Rffl-002 82807422-82829043 protein_coding
  ENSMUST00000108173 Rffl-203 82803822-82871210 protein_coding
  ENSMUST00000126660 Rffl-004 82812669-82846092 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeBladderBrainColonLiverOvaryPlacentaTestisENSMUST00000021036ENSMUST00000071152ENSMUST00000074515ENSMUST00000093975ENSMUST00000108173
Transcript ID Adipose Bladder Brain Colon Liver Ovary Placenta Testis
ENSMUST00000021036 N/A N/A N/A N/A N/A N/A N/A 52.068±14.62
ENSMUST00000071152 3.300±0.00 N/A N/A 4.095±0.89 5.114±1.30 N/A N/A N/A
ENSMUST00000074515 N/A 7.203±0.00 2.542±0.96 N/A 6.305±0.00 4.378±0.00 7.189±0.00 17.404±7.51
ENSMUST00000093975 N/A N/A N/A N/A N/A N/A 3.328±0.00 N/A
ENSMUST00000108173 N/A 3.278±0.00 N/A 5.579±0.63 5.668±1.61 N/A 8.823±4.69 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00055Q CIL_00055Q_0002 CGP 11:82764345-82804274
CIL_00055O CIL_00055O_0002 CGP 11:82781108-82871210

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002020 IEA protease binding
GO:0002039 IEA p53 binding
GO:0002947 ISS tumor necrosis factor receptor superfamily complex
GO:0005737 ISS cytoplasm
GO:0005886 ISS plasma membrane
GO:0006511 ISS ubiquitin-dependent protein catabolic process
GO:0006886 IDA intracellular protein transport
GO:0008270 IEA zinc ion binding
GO:0010008 ISS endosome membrane
GO:0010762 IMP regulation of fibroblast migration
GO:0010804 ISS negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0016020 IEA membrane
GO:0016023 IDA cytoplasmic membrane-bounded vesicle
GO:0016874 IEA ligase activity
GO:0019901 IEA protein kinase binding
GO:0031625 IEA ubiquitin protein ligase binding
GO:0042787 ISS protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161 ISS proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0061630 ISS ubiquitin protein ligase activity
GO:0070936 ISS protein K48-linked ubiquitination
GO:1901797 ISS negative regulation of signal transduction by p53 class mediator
GO:1902042 ISS negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001271 ISS negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000042833 RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase protein_coding Danio_rerio
ENSG00000092871 RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase protein_coding Homo_sapiens

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