C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: endothelin 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021367 Edn1 10090 + 13:42301270-42307989 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000021796 Edn1-201 42301270-42307989 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000021796
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000021796 3.051±0.64 0.349±0.10 1.505±0.38 0.461±0.05 1.856±0.36 6.282±0.36 1.356±0.20 0.797±0.20 0.322±0.23 9.128±1.91 0.626±0.21 1.948±0.55 1.119±0.99 0.281±0.17

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008Y7 CIL_0008Y7_0002 VISTA 13:41958101-42559051
CIL_00037V CIL_00037V_0002 CGP 13:42052021-42307989
CIL_0003IC CIL_0003IC_0002 CGP 13:42301270-43138526

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0001501 IMP skeletal system development
GO:0001516 IEA prostaglandin biosynthetic process
GO:0001569 IMP patterning of blood vessels
GO:0001666 IMP response to hypoxia
GO:0001701 IMP in utero embryonic development
GO:0001821 IEA histamine secretion
GO:0003100 IEA regulation of systemic arterial blood pressure by endothelin
GO:0005102 IDA receptor binding
GO:0005125 IEA cytokine activity
GO:0005179 IEA hormone activity
GO:0005515 IPI protein binding
GO:0005615 IDA extracellular space
GO:0005737 IEA cytoplasm
GO:0006885 IDA regulation of pH
GO:0007166 IEA cell surface receptor signaling pathway
GO:0007186 TAS G-protein coupled receptor signaling pathway
GO:0007204 IEA positive regulation of cytosolic calcium ion concentration
GO:0007205 IDA protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007267 IEA cell-cell signaling
GO:0007507 IMP heart development
GO:0007585 IMP respiratory gaseous exchange
GO:0007589 IMP body fluid secretion
GO:0008217 IMP regulation of blood pressure
GO:0008284 IDA positive regulation of cell proliferation
GO:0009953 IMP dorsal/ventral pattern formation
GO:0010193 IEA response to ozone
GO:0010259 IEA multicellular organismal aging
GO:0010460 IEA positive regulation of heart rate
GO:0010613 IEA positive regulation of cardiac muscle hypertrophy
GO:0010870 IEA positive regulation of receptor biosynthetic process
GO:0014032 IMP neural crest cell development
GO:0014065 IEA phosphatidylinositol 3-kinase signaling
GO:0014823 IEA response to activity
GO:0014824 IEA artery smooth muscle contraction
GO:0014826 IEA vein smooth muscle contraction
GO:0015758 IDA glucose transport
GO:0016049 IEA cell growth
GO:0019229 IEA regulation of vasoconstriction
GO:0019233 IEA sensory perception of pain
GO:0019722 IEA calcium-mediated signaling
GO:0030072 IEA peptide hormone secretion
GO:0030185 IEA nitric oxide transport
GO:0030335 IEA positive regulation of cell migration
GO:0030818 IGI negative regulation of cAMP biosynthetic process
GO:0031583 IDA phospholipase D-activating G-protein coupled receptor signaling pathway
GO:0031707 IPI endothelin A receptor binding
GO:0031708 IEA endothelin B receptor binding
GO:0032269 IEA negative regulation of cellular protein metabolic process
GO:0032308 IEA positive regulation of prostaglandin secretion
GO:0032496 IEA response to lipopolysaccharide
GO:0033093 IEA Weibel-Palade body
GO:0033574 IEA response to testosterone
GO:0034392 IEA negative regulation of smooth muscle cell apoptotic process
GO:0034696 IEA response to prostaglandin F
GO:0035094 IEA response to nicotine
GO:0035556 IEA intracellular signal transduction
GO:0035690 IEA cellular response to drug
GO:0035810 IGI positive regulation of urine volume
GO:0035815 IMP positive regulation of renal sodium excretion
GO:0035994 IEA response to muscle stretch
GO:0042045 IEA epithelial fluid transport
GO:0042310 IEA vasoconstriction
GO:0042313 IEA protein kinase C deactivation
GO:0042474 IMP middle ear morphogenesis
GO:0042482 IEA positive regulation of odontogenesis
GO:0042493 IEA response to drug
GO:0042554 IEA superoxide anion generation
GO:0043179 IMP rhythmic excitation
GO:0043200 IEA response to amino acid
GO:0043406 IEA positive regulation of MAP kinase activity
GO:0043507 IEA positive regulation of JUN kinase activity
GO:0044321 IEA response to leptin
GO:0045178 IEA basal part of cell
GO:0045793 IEA positive regulation of cell size
GO:0045840 IEA positive regulation of mitosis
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0045987 IEA positive regulation of smooth muscle contraction
GO:0046887 IEA positive regulation of hormone secretion
GO:0046888 IEA negative regulation of hormone secretion
GO:0048016 IEA inositol phosphate-mediated signaling
GO:0048237 IEA rough endoplasmic reticulum lumen
GO:0048514 IMP blood vessel morphogenesis
GO:0048661 IEA positive regulation of smooth muscle cell proliferation
GO:0051216 IMP cartilage development
GO:0051482 IDA positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051771 IEA negative regulation of nitric-oxide synthase biosynthetic process
GO:0051899 IEA membrane depolarization
GO:0051930 IEA regulation of sensory perception of pain
GO:0060137 IEA maternal process involved in parturition
GO:0060298 IEA positive regulation of sarcomere organization
GO:0060585 IEA positive regulation of prostaglandin-endoperoxide synthase activity
GO:0071277 IEA cellular response to calcium ion
GO:0071346 IEA cellular response to interferon-gamma
GO:0071347 IEA cellular response to interleukin-1
GO:0071356 IEA cellular response to tumor necrosis factor
GO:0071375 IEA cellular response to peptide hormone stimulus
GO:0071385 IEA cellular response to glucocorticoid stimulus
GO:0071389 IEA cellular response to mineralocorticoid stimulus
GO:0071398 IEA cellular response to fatty acid
GO:0071456 IEA cellular response to hypoxia
GO:0071548 IEA response to dexamethasone
GO:0071559 IEA response to transforming growth factor beta
GO:0071560 IEA cellular response to transforming growth factor beta stimulus
GO:0090023 IEA positive regulation of neutrophil chemotaxis
GO:1902074 IEA response to salt

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000036912 edn1 endothelin 1 protein_coding Danio_rerio
ENSG00000078401 EDN1 endothelin 1 protein_coding Homo_sapiens

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