C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: receptor (TNFRSF)-interacting serine-threonine kinase 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021408 Ripk1 10090 + 13:34002363-34035170 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000021844 Ripk1-001 34002363-34033677 protein_coding
  ENSMUST00000163418 Ripk1-003 34002400-34014686 retained_intron
  ENSMUST00000167374 Ripk1-002 34002874-34035170 protein_coding
  ENSMUST00000171137 Ripk1-004 34009698-34032782 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonKidneyLiverLungOvaryPlacentaENSMUST00000021844ENSMUST00000163418ENSMUST00000167374
Transcript ID Adipose Adrenal Brain Breast Colon Kidney Liver Lung Ovary Placenta
ENSMUST00000021844 5.349±0.21 N/A N/A 7.027±0.00 9.329±2.33 4.094±0.75 3.819±0.79 7.351±0.14 6.196±0.00 9.550±4.77
ENSMUST00000163418 N/A 24.139±5.50 N/A 16.933±0.00 17.522±3.75 N/A N/A 13.521±1.97 16.395±3.25 N/A
ENSMUST00000167374 4.550±0.31 N/A 1.376±0.24 5.676±0.08 N/A 2.969±0.32 2.653±0.14 N/A 6.482±2.18 3.666±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00081I CIL_00081I_0002 VISTA 13:33848088-34450616
CIL_000160 CIL_000160_000L CGP 13:33879816-34002794
CIL_00038C CIL_00038C_0002 CGP 13:33917918-34002794
CIL_000823 CIL_000823_0002 VISTA 13:33947185-34549843
CIL_00038F CIL_00038F_0002 CGP 13:33964659-34035170
CIL_00038E CIL_00038E_0002 CGP 13:34002363-34074074

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001934 ISS positive regulation of protein phosphorylation
GO:0004672 ISS protein kinase activity
GO:0004674 ISS protein serine/threonine kinase activity
GO:0005123 IEA death receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005739 IEA mitochondrion
GO:0006915 ISS apoptotic process
GO:0010942 IEA positive regulation of cell death
GO:0016032 IEA viral process
GO:0031264 IEA death-inducing signaling complex
GO:0031625 IEA ubiquitin protein ligase binding
GO:0032403 IEA protein complex binding
GO:0032757 IEA positive regulation of interleukin-8 production
GO:0032760 IEA positive regulation of tumor necrosis factor production
GO:0034612 IEA response to tumor necrosis factor
GO:0036289 ISS peptidyl-serine autophosphorylation
GO:0042327 IMP positive regulation of phosphorylation
GO:0042802 IEA identical protein binding
GO:0043065 ISS positive regulation of apoptotic process
GO:0043068 IEA positive regulation of programmed cell death
GO:0043123 ISS positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 IEA negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043234 IEA protein complex
GO:0043235 IEA receptor complex
GO:0043410 IMP positive regulation of MAPK cascade
GO:0044257 ISS cellular protein catabolic process
GO:0045121 IEA membrane raft
GO:0045651 IEA positive regulation of macrophage differentiation
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0046330 IMP positive regulation of JNK cascade
GO:0046777 IEA protein autophosphorylation
GO:0051092 IMP positive regulation of NF-kappaB transcription factor activity
GO:0051260 ISS protein homooligomerization
GO:0051291 ISS protein heterooligomerization
GO:0051347 IGI positive regulation of transferase activity
GO:0060545 IEA positive regulation of necroptotic process
GO:0070231 IMP T cell apoptotic process
GO:0070266 IGI necroptotic process
GO:0070513 IEA death domain binding
GO:0070926 IEA regulation of ATP:ADP antiporter activity
GO:0071356 ISS cellular response to tumor necrosis factor
GO:0071363 IMP cellular response to growth factor stimulus
GO:0097191 IEA extrinsic apoptotic signaling pathway
GO:0097342 IDA ripoptosome
GO:0097343 ISS ripoptosome assembly
GO:0097527 IMP necroptotic signaling pathway
GO:1901026 IGI ripoptosome assembly involved in necroptotic process
GO:1990000 ISS amyloid fibril formation
GO:2000377 IMP regulation of reactive oxygen species metabolic process
GO:2001237 IGI negative regulation of extrinsic apoptotic signaling pathway
GO:2001238 IGI positive regulation of extrinsic apoptotic signaling pathway
GO:2001240 IMP negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000006677 ripk1l receptor (TNFRSF)-interacting serine-threonine kinase 1, like protein_coding Danio_rerio
ENSG00000137275 RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 protein_coding Homo_sapiens

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