C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: msh homeobox 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021469 Msx2 10090 - 13:53466884-53473074 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000021922 Msx2-001 53466884-53473074 protein_coding
  ENSMUST00000188606 Msx2-002 53471506-53473074 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000021922ENSMUST00000188606
Transcript ID Adipose Adrenal Bladder Brain Breast Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000021922 3.883±3.93 0.679±0.27 9.017±1.94 0.378±0.34 7.017±2.88 0.143±0.03 0.170±0.03 0.034±0.04 N/A 0.043±0.03 1.276±0.69 2.846±1.80 0.330±0.17
ENSMUST00000188606 N/A 0.139±0.00 N/A N/A N/A N/A 0.055±0.00 N/A 0.022±0.00 N/A 0.362±0.00 N/A 0.096±0.03

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00086T CIL_00086T_0002 VISTA 13:53163203-53764849

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IGI negative regulation of transcription from RNA polymerase II promoter
GO:0000977 IMP RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
GO:0000989 IDA transcription factor binding transcription factor activity
GO:0001227 IDA RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001503 IMP ossification
GO:0001649 IDA osteoblast differentiation
GO:0002063 IMP chondrocyte development
GO:0002076 IMP osteoblast development
GO:0003148 IGI outflow tract septum morphogenesis
GO:0003151 IGI outflow tract morphogenesis
GO:0003198 IGI epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003416 IMP endochondral bone growth
GO:0003677 IDA DNA binding
GO:0003712 IDA transcription cofactor activity
GO:0005515 IPI protein binding
GO:0005634 IEA nucleus
GO:0005667 IPI transcription factor complex
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0008134 IPI transcription factor binding
GO:0008285 IGI negative regulation of cell proliferation
GO:0009952 IGI anterior/posterior pattern specification
GO:0023019 IGI signal transduction involved in regulation of gene expression
GO:0030326 IGI embryonic limb morphogenesis
GO:0030509 IGI BMP signaling pathway
GO:0030513 IGI positive regulation of BMP signaling pathway
GO:0032792 IDA negative regulation of CREB transcription factor activity
GO:0035115 IGI embryonic forelimb morphogenesis
GO:0035116 IGI embryonic hindlimb morphogenesis
GO:0035313 IMP wound healing, spreading of epidermal cells
GO:0035880 IGI embryonic nail plate morphogenesis
GO:0042060 IMP wound healing
GO:0042476 IMP odontogenesis
GO:0042733 IGI embryonic digit morphogenesis
GO:0042981 IDA regulation of apoptotic process
GO:0043065 IEA positive regulation of apoptotic process
GO:0043066 IGI negative regulation of apoptotic process
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0045599 IDA negative regulation of fat cell differentiation
GO:0045617 IMP negative regulation of keratinocyte differentiation
GO:0045669 IDA positive regulation of osteoblast differentiation
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0048863 IGI stem cell differentiation
GO:0051216 IMP cartilage development
GO:0051795 IMP positive regulation of catagen
GO:0060346 IMP bone trabecula formation
GO:0060349 IGI bone morphogenesis
GO:0060364 IMP frontal suture morphogenesis
GO:0060444 IMP branching involved in mammary gland duct morphogenesis
GO:0061180 IGI mammary gland epithelium development
GO:0061312 IGI BMP signaling pathway involved in heart development
GO:0070166 IMP enamel mineralization
GO:0071363 IDA cellular response to growth factor stimulus
GO:0071392 IDA cellular response to estradiol stimulus
GO:0090427 IPI activation of meiosis
GO:2000678 IDA negative regulation of transcription regulatory region DNA binding
GO:2001055 IGI positive regulation of mesenchymal cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000008886 msxb muscle segment homeobox B protein_coding Danio_rerio
ENSDARG00000015674 msxc muscle segment homeobox C protein_coding Danio_rerio
ENSG00000120149 MSX2 msh homeobox 2 protein_coding Homo_sapiens

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