C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: peptidylprolyl isomerase F (cyclophilin F)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021868 Ppif 10090 + 14:25694154-25700468 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000022419 Ppif-001 25694170-25700468 protein_coding
  ENSMUST00000125881 Ppif-002 25694154-25700464 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000022419ENSMUST00000125881
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000022419 18.507±2.31 55.877±7.89 8.728±2.28 14.513±8.72 24.815±7.35 117.643±46.50 181.160±20.63 67.432±16.34 36.803±8.67 12.429±2.80 16.576±1.36 23.837±12.42 19.975±12.36 3.415±0.25
ENSMUST00000125881 0.983±0.05 N/A 1.463±0.35 1.697±0.00 2.219±0.08 N/A N/A N/A N/A 1.575±0.33 N/A 3.180±1.02 0.484±0.26 1.086±0.51

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008PL CIL_0008PL_0002 VISTA 14:25224623-25826558
CIL_0007WJ CIL_0007WJ_0002 VISTA 14:25284835-25888921
CIL_0001G8 CIL_0001G8_0002 CGP 14:25459185-25700468
CIL_0003H9 CIL_0003H9_0002 CGP 14:25694154-25769039

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000413 TAS protein peptidyl-prolyl isomerization
GO:0002931 IMP response to ischemia
GO:0003755 TAS peptidyl-prolyl cis-trans isomerase activity
GO:0005515 IPI protein binding
GO:0005739 IDA mitochondrion
GO:0005743 IEA mitochondrial inner membrane
GO:0005753 ISS mitochondrial proton-transporting ATP synthase complex
GO:0005757 TAS mitochondrial permeability transition pore complex
GO:0005759 IEA mitochondrial matrix
GO:0006457 IEA protein folding
GO:0006979 IGI response to oxidative stress
GO:0008637 IGI apoptotic mitochondrial changes
GO:0010849 IMP regulation of proton-transporting ATPase activity, rotational mechanism
GO:0010939 IDA regulation of necrotic cell death
GO:0016018 IEA cyclosporin A binding
GO:0032780 IMP negative regulation of ATPase activity
GO:0042277 IEA peptide binding
GO:0042981 IEA regulation of apoptotic process
GO:0043066 ISS negative regulation of apoptotic process
GO:0046902 IMP regulation of mitochondrial membrane permeability
GO:0070266 IGI necroptotic process
GO:0070301 IMP cellular response to hydrogen peroxide
GO:0071243 IMP cellular response to arsenic-containing substance
GO:0071277 IMP cellular response to calcium ion
GO:0090200 IMP positive regulation of release of cytochrome c from mitochondria
GO:0090201 ISS negative regulation of release of cytochrome c from mitochondria
GO:0090324 IMP negative regulation of oxidative phosphorylation
GO:1902445 IMP regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
GO:2000276 IMP negative regulation of oxidative phosphorylation uncoupler activity
GO:2001243 ISS negative regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000052842 ppifb peptidylprolyl isomerase Fb protein_coding Danio_rerio
ENSG00000108179 PPIF peptidylprolyl isomerase F protein_coding Homo_sapiens

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