C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: peptidylprolyl isomerase F
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000108179 PPIF 9606 + 10:79347469-79355337 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000225174 PPIF-001 79347478-79355337 protein_coding
  ENST00000394579 PPIF-201 79347487-79355336 protein_coding
  ENST00000448165 PPIF-004 79347658-79354086 protein_coding
  ENST00000472580 PPIF-003 79347469-79353706 nonsense_mediated_decay
  ENST00000492149 PPIF-005 79347500-79350035 processed_transcript
  ENST00000498681 PPIF-002 79347469-79351609 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000225174ENST00000448165ENST00000498681
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000225174 8.543±0.00 16.167±0.00 2.476±0.00 11.256±9.00 6.888±6.18 8.045±6.47 22.809±19.99 27.947±18.94 38.917±0.00 7.083±6.91 4.523±1.70 20.952±15.96 25.054±2.10 21.567±7.99
ENST00000448165 3.212±0.00 7.380±0.00 N/A 14.708±0.00 5.670±4.82 N/A N/A N/A N/A 4.603±3.81 5.683±0.00 N/A 12.896±0.00 N/A
ENST00000498681 N/A N/A N/A N/A 1.445±0.00 4.142±0.00 N/A N/A 2.288±0.00 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008PL CIL_0008PL_0001 VISTA 10:78848267-79450832
CIL_0007WJ CIL_0007WJ_0001 VISTA 10:78920559-79524285
CIL_0001G8 CIL_0001G8_0001 CGP 10:79069035-79355337
CIL_0003H9 CIL_0003H9_0001 CGP 10:79347469-79445627

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000413 IEA protein peptidyl-prolyl isomerization
GO:0002931 ISS response to ischemia
GO:0003755 IEA peptidyl-prolyl cis-trans isomerase activity
GO:0005515 IPI protein binding
GO:0005739 IEA mitochondrion
GO:0005743 IEA mitochondrial inner membrane
GO:0005753 ISS mitochondrial proton-transporting ATP synthase complex
GO:0005759 IEA mitochondrial matrix
GO:0006457 IEA protein folding
GO:0006979 IEA response to oxidative stress
GO:0008637 IEA apoptotic mitochondrial changes
GO:0010849 ISS regulation of proton-transporting ATPase activity, rotational mechanism
GO:0010939 IEA regulation of necrotic cell death
GO:0016018 IEA cyclosporin A binding
GO:0016020 TAS membrane
GO:0032780 ISS negative regulation of ATPase activity
GO:0042277 IEA peptide binding
GO:0042981 IEA regulation of apoptotic process
GO:0043066 IDA negative regulation of apoptotic process
GO:0046902 ISS regulation of mitochondrial membrane permeability
GO:0070266 IEA necroptotic process
GO:0070301 IMP cellular response to hydrogen peroxide
GO:0071243 ISS cellular response to arsenic-containing substance
GO:0071277 ISS cellular response to calcium ion
GO:0090200 ISS positive regulation of release of cytochrome c from mitochondria
GO:0090201 IDA negative regulation of release of cytochrome c from mitochondria
GO:0090324 ISS negative regulation of oxidative phosphorylation
GO:1902445 IMP regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
GO:2000276 ISS negative regulation of oxidative phosphorylation uncoupler activity
GO:2001243 IMP negative regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000052842 ppifb peptidylprolyl isomerase Fb protein_coding Danio_rerio
ENSMUSG00000021868 Ppif peptidylprolyl isomerase F (cyclophilin F) protein_coding Mus_musculus

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