C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: GATA binding protein 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000021944 Gata4 10090 - 14:63198922-63271692 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000067417 Gata4-002 63198922-63245271 protein_coding
  ENSMUST00000118022 Gata4-001 63198922-63245248 protein_coding
  ENSMUST00000121312 Gata4-003 63198924-63213607 protein_coding
  ENSMUST00000132122 Gata4-006 63241102-63271692 protein_coding
  ENSMUST00000137244 Gata4-004 63241115-63271124 protein_coding
  ENSMUST00000156782 Gata4-005 63241115-63271124 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000067417ENSMUST00000118022ENSMUST00000121312
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000067417 N/A 0.471±0.26 0.201±0.04 N/A 0.026±0.00 0.095±0.07 6.212±0.79 0.024±0.03 1.869±0.52 0.712±0.06 N/A 28.006±10.98 1.464±1.07 1.656±0.93
ENSMUST00000118022 0.068±0.03 1.540±0.60 0.388±0.17 N/A 0.065±0.01 0.072±0.04 19.668±1.64 0.030±0.01 3.523±1.07 0.609±0.25 N/A 48.609±27.41 2.913±2.12 1.808±1.48
ENSMUST00000121312 0.083±0.02 N/A 0.215±0.00 0.003±0.00 0.199±0.08 0.092±0.05 13.844±2.21 0.040±0.02 3.220±1.35 0.316±0.02 0.039±0.00 30.394±8.26 1.751±0.86 1.745±0.60

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0007PQ CIL_0007PQ_0002 VISTA 14:62762164-63363066
CIL_000919 CIL_000919_0002 VISTA 14:62906721-63507169
CIL_0008Y4 CIL_0008Y4_0002 VISTA 14:63067789-63669845

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000790 IDA nuclear chromatin
GO:0000977 IDA RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 IDA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001076 IDA RNA polymerase II transcription factor binding transcription factor activity
GO:0001158 IEA enhancer sequence-specific DNA binding
GO:0001701 IMP in utero embryonic development
GO:0001702 IMP gastrulation with mouth forming second
GO:0001706 IMP endoderm formation
GO:0001947 IMP heart looping
GO:0003007 IMP heart morphogenesis
GO:0003151 TAS outflow tract morphogenesis
GO:0003181 IGI atrioventricular valve morphogenesis
GO:0003190 IGI atrioventricular valve formation
GO:0003192 TAS mitral valve formation
GO:0003195 TAS tricuspid valve formation
GO:0003197 IGI endocardial cushion development
GO:0003215 IMP cardiac right ventricle morphogenesis
GO:0003229 IGI ventricular cardiac muscle tissue development
GO:0003279 IGI cardiac septum development
GO:0003281 IMP ventricular septum development
GO:0003289 IMP atrial septum primum morphogenesis
GO:0003290 IEA atrial septum secundum morphogenesis
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713 IEA transcription coactivator activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006357 IDA regulation of transcription from RNA polymerase II promoter
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0007267 IMP cell-cell signaling
GO:0007283 IMP spermatogenesis
GO:0007507 IMP heart development
GO:0008134 IEA transcription factor binding
GO:0008270 IEA zinc ion binding
GO:0008584 IEA male gonad development
GO:0009612 IEA response to mechanical stimulus
GO:0010468 IGI regulation of gene expression
GO:0010507 IEA negative regulation of autophagy
GO:0010575 IDA positive regulation vascular endothelial growth factor production
GO:0014898 IMP cardiac muscle hypertrophy in response to stress
GO:0023019 IDA signal transduction involved in regulation of gene expression
GO:0030509 IDA BMP signaling pathway
GO:0030513 IEA positive regulation of BMP signaling pathway
GO:0032526 IDA response to retinoic acid
GO:0033613 IEA activating transcription factor binding
GO:0035050 IMP embryonic heart tube development
GO:0035054 IMP embryonic heart tube anterior/posterior pattern specification
GO:0035239 IGI tube morphogenesis
GO:0035914 NAS skeletal muscle cell differentiation
GO:0036302 IGI atrioventricular canal development
GO:0042493 IEA response to drug
GO:0043565 IDA sequence-specific DNA binding
GO:0043627 IDA response to estrogen
GO:0044212 ISO transcription regulatory region DNA binding
GO:0045766 IDA positive regulation of angiogenesis
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0048557 IMP embryonic digestive tract morphogenesis
GO:0048598 IMP embryonic morphogenesis
GO:0048617 IMP embryonic foregut morphogenesis
GO:0048738 IGI cardiac muscle tissue development
GO:0051525 IEA NFAT protein binding
GO:0051891 IEP positive regulation of cardioblast differentiation
GO:0055007 IGI cardiac muscle cell differentiation
GO:0060008 IMP Sertoli cell differentiation
GO:0060043 IMP regulation of cardiac muscle cell proliferation
GO:0060045 IGI positive regulation of cardiac muscle cell proliferation
GO:0060070 IDA canonical Wnt signaling pathway
GO:0060290 IEA transdifferentiation
GO:0060395 IDA SMAD protein signal transduction
GO:0060413 IEA atrial septum morphogenesis
GO:0060425 TAS lung morphogenesis
GO:0060464 IMP lung lobe formation
GO:0060540 TAS diaphragm morphogenesis
GO:0060575 ISO intestinal epithelial cell differentiation
GO:0060979 TAS vasculogenesis involved in coronary vascular morphogenesis
GO:0061049 IEA cell growth involved in cardiac muscle cell development
GO:0070410 IEA co-SMAD binding
GO:0071333 IEA cellular response to glucose stimulus
GO:0071371 IDA cellular response to gonadotropin stimulus
GO:0071372 IDA cellular response to follicle-stimulating hormone stimulus
GO:0072148 IMP epithelial cell fate commitment
GO:0072520 IMP seminiferous tubule development
GO:0086004 IEA regulation of cardiac muscle cell contraction

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000035759 gata4 GATA-binding protein 4 protein_coding Danio_rerio
ENSG00000136574 GATA4 GATA binding protein 4 protein_coding Homo_sapiens

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