C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: serine/threonine kinase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022329 Stk3 10090 - 15:34875496-35155806 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000018476 Stk3-001 34875496-35155806 protein_coding
  ENSMUST00000067033 Stk3-002 34875673-35155750 protein_coding
  ENSMUST00000128425 Stk3-004 34958564-34999922 retained_intron
  ENSMUST00000138841 Stk3-003 35072479-35155669 nonsense_mediated_decay

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000018476ENSMUST00000067033ENSMUST00000128425ENSMUST00000138841
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000018476 1.921±0.99 0.623±0.18 3.413±1.31 1.305±0.25 1.068±0.14 0.964±0.32 0.501±0.16 1.254±0.37 2.803±2.03 2.333±0.31 0.846±0.20 3.609±3.53 5.774±1.19 0.599±0.19
ENSMUST00000067033 0.584±0.34 0.616±0.00 1.536±0.00 1.922±1.52 0.483±0.19 0.273±0.14 0.729±0.07 0.753±0.19 1.021±0.73 1.084±0.00 0.191±0.05 3.347±3.94 3.130±2.39 1.161±1.06
ENSMUST00000128425 N/A N/A N/A N/A N/A 1.548±0.00 N/A N/A N/A N/A N/A 2.377±1.39 N/A 4.653±0.00
ENSMUST00000138841 N/A N/A N/A 4.007±0.00 N/A N/A N/A N/A 0.553±0.00 N/A N/A 2.039±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008YL CIL_0008YL_0002 VISTA 15:34528818-35129716

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 ISS magnesium ion binding
GO:0001841 IGI neural tube formation
GO:0003157 IGI endocardium development
GO:0004674 ISS protein serine/threonine kinase activity
GO:0005515 IEA protein binding
GO:0005524 ISS ATP binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0006468 ISS protein phosphorylation
GO:0007417 IGI central nervous system development
GO:0008285 IGI negative regulation of cell proliferation
GO:0035329 IMP hippo signaling
GO:0035556 ISS intracellular signal transduction
GO:0043065 ISS positive regulation of apoptotic process
GO:0046330 IGI positive regulation of JNK cascade
GO:0046621 IGI negative regulation of organ growth
GO:0046983 ISS protein dimerization activity
GO:0051897 IGI positive regulation of protein kinase B signaling
GO:0060215 IGI primitive hemopoiesis
GO:0060706 IGI cell differentiation involved in embryonic placenta development
GO:0090090 IGI negative regulation of canonical Wnt signaling pathway
GO:0097284 IGI hepatocyte apoptotic process
GO:1902043 IGI positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011312 stk3 serine/threonine kinase 3 (STE20 homolog, yeast) protein_coding Danio_rerio
ENSG00000104375 STK3 serine/threonine kinase 3 protein_coding Homo_sapiens

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