C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: serine/threonine kinase 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000104375 STK3 9606 - 8:98401403-98942827 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000419617 STK3-001 98454633-98825681 protein_coding
  ENST00000424861 STK3-004 98595330-98825666 nonsense_mediated_decay
  ENST00000517832 STK3-014 98401403-98526926 processed_transcript
  ENST00000518165 STK3-005 98548091-98825671 protein_coding
  ENST00000518582 STK3-012 98547960-98651724 processed_transcript
  ENST00000518627 STK3-010 98553330-98601661 processed_transcript
  ENST00000519420 STK3-016 98883754-98942827 protein_coding
  ENST00000520053 STK3-008 98579759-98596392 retained_intron
  ENST00000520440 STK3-013 98526415-98548162 retained_intron
  ENST00000520653 STK3-007 98594973-98602276 processed_transcript
  ENST00000521649 STK3-006 98579696-98825646 nonsense_mediated_decay
  ENST00000521768 STK3-017 98594877-98602182 processed_transcript
  ENST00000522924 STK3-009 98579670-98595250 processed_transcript
  ENST00000523159 STK3-011 98547966-98602255 processed_transcript
  ENST00000523567 STK3-015 98875257-98883795 processed_transcript
  ENST00000523601 STK3-002 98454695-98942571 protein_coding
  ENST00000523960 STK3-003 98878898-98942645 retained_intron
  ENST00000617590 STK3-201 98454631-98825671 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000419617ENST00000424861ENST00000518582
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000419617 5.879±0.00 4.318±0.00 2.975±0.00 1.243±0.24 4.515±0.28 4.854±2.68 2.382±0.73 6.275±3.60 5.086±3.07 6.856±0.19 1.559±0.94 8.391±3.30 8.096±1.45 5.879±0.72
ENST00000424861 N/A N/A N/A N/A 1.820±0.00 0.887±0.00 N/A N/A N/A 3.348±0.00 N/A 3.323±0.00 N/A N/A
ENST00000518582 N/A N/A N/A N/A N/A N/A 3.004±0.00 N/A N/A N/A N/A 18.457±0.00 25.163±0.00 32.845±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008YL CIL_0008YL_0001 VISTA 8:98116253-98717204

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IDA magnesium ion binding
GO:0001841 IEA neural tube formation
GO:0003157 IEA endocardium development
GO:0004672 TAS:IEA protein kinase activity
GO:0004674 IDA:IEA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IDA:IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0006468 IDA:IEA protein phosphorylation
GO:0006915 TAS apoptotic process
GO:0007165 TAS:IEA signal transduction
GO:0007417 IEA central nervous system development
GO:0008285 IEA negative regulation of cell proliferation
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0035329 TAS hippo signaling
GO:0035556 IDA intracellular signal transduction
GO:0043065 ISS positive regulation of apoptotic process
GO:0043539 TAS protein serine/threonine kinase activator activity
GO:0046330 IEA positive regulation of JNK cascade
GO:0046621 IEA negative regulation of organ growth
GO:0046983 ISS protein dimerization activity
GO:0051897 IEA positive regulation of protein kinase B signaling
GO:0060215 IEA primitive hemopoiesis
GO:0060706 IEA cell differentiation involved in embryonic placenta development
GO:0071902 TAS positive regulation of protein serine/threonine kinase activity
GO:0090090 IMP negative regulation of canonical Wnt signaling pathway
GO:0097284 IEA hepatocyte apoptotic process
GO:1902043 IEA positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000011312 stk3 serine/threonine kinase 3 (STE20 homolog, yeast) protein_coding Danio_rerio
ENSMUSG00000022329 Stk3 serine/threonine kinase 3 protein_coding Mus_musculus

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