C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: peroxisome proliferator activated receptor alpha
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022383 Ppara 10090 + 15:85734983-85802819 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000057979 Ppara-003 85736131-85801748 protein_coding
  ENSMUST00000109422 Ppara-001 85735776-85802819 protein_coding
  ENSMUST00000109423 Ppara-002 85735564-85802163 protein_coding
  ENSMUST00000134880 Ppara-005 85734983-85777632 processed_transcript
  ENSMUST00000136453 Ppara-006 85772214-85777767 processed_transcript
  ENSMUST00000138813 Ppara-004 85735639-85777727 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBrainBreastColonLiverLungMuscleOvaryPlacentaTestisENSMUST00000057979ENSMUST00000109422ENSMUST00000109423ENSMUST00000136453ENSMUST00000138813
Transcript ID Adrenal Brain Breast Colon Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000057979 1.161±0.36 0.266±0.00 N/A 0.741±0.00 3.536±0.01 0.222±0.00 N/A 0.971±0.18 0.097±0.05 0.248±0.15
ENSMUST00000109422 1.657±0.64 N/A 0.313±0.11 1.031±0.40 6.830±0.28 0.291±0.06 0.320±0.00 0.840±0.34 0.079±0.02 0.185±0.11
ENSMUST00000109423 0.565±0.00 N/A 0.454±0.00 0.894±0.25 N/A N/A N/A 0.640±0.00 0.062±0.02 0.395±0.06
ENSMUST00000136453 N/A N/A N/A N/A 50.176±1.92 N/A N/A N/A N/A N/A
ENSMUST00000138813 N/A N/A N/A N/A N/A N/A N/A 6.638±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008KW CIL_0008KW_0002 VISTA 15:85164142-85764949
CIL_000469 CIL_000469_0002 CGP 15:85535439-85802819
CIL_0001Q1 CIL_0001Q1_0002 CGP 15:85734983-85811697

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IEA negative regulation of transcription from RNA polymerase II promoter
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001103 IEA RNA polymerase II repressing transcription factor binding
GO:0001190 IDA RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0001666 IEA response to hypoxia
GO:0003677 IDA DNA binding
GO:0003700 IMP sequence-specific DNA binding transcription factor activity
GO:0003707 TAS steroid hormone receptor activity
GO:0004872 IDA receptor activity
GO:0004879 IEA ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 TAS nucleus
GO:0005654 TAS nucleoplasm
GO:0006006 TAS glucose metabolic process
GO:0006351 IEA transcription, DNA-templated
GO:0006355 TAS regulation of transcription, DNA-templated
GO:0006629 TAS lipid metabolic process
GO:0006631 TAS fatty acid metabolic process
GO:0007507 IEA heart development
GO:0008144 ISS drug binding
GO:0008270 IEA zinc ion binding
GO:0008289 IDA lipid binding
GO:0008544 IMP epidermis development
GO:0010468 IMP regulation of gene expression
GO:0010871 IEA negative regulation of receptor biosynthetic process
GO:0010887 IEA negative regulation of cholesterol storage
GO:0010891 IEA negative regulation of sequestering of triglyceride
GO:0019217 IMP regulation of fatty acid metabolic process
GO:0019902 IEA phosphatase binding
GO:0019904 IEA protein domain specific binding
GO:0030522 IEA intracellular receptor signaling pathway
GO:0031624 IEA ubiquitin conjugating enzyme binding
GO:0032091 IEA negative regulation of protein binding
GO:0032099 IMP negative regulation of appetite
GO:0032403 IEA protein complex binding
GO:0032868 IEA response to insulin
GO:0032922 IDA circadian regulation of gene expression
GO:0035095 IEA behavioral response to nicotine
GO:0042060 IMP wound healing
GO:0042157 IEA lipoprotein metabolic process
GO:0042752 IDA regulation of circadian rhythm
GO:0043401 IEA steroid hormone mediated signaling pathway
GO:0043565 IDA sequence-specific DNA binding
GO:0045722 IMP positive regulation of gluconeogenesis
GO:0045776 IEA negative regulation of blood pressure
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046321 IMP positive regulation of fatty acid oxidation
GO:0046982 TAS protein heterodimerization activity
GO:0051525 IEA NFAT protein binding
GO:0070166 IMP enamel mineralization
GO:0072363 IEA regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoter
GO:0072366 IEA regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
GO:0072369 IEA regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
GO:0097371 IEA MDM2/MDM4 family protein binding
GO:1901215 IEA negative regulation of neuron death
GO:2000678 IEA negative regulation of transcription regulatory region DNA binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000031777 pparaa peroxisome proliferator-activated receptor alpha a protein_coding Danio_rerio
ENSDARG00000054323 pparab peroxisome proliferator activated receptor alpha b protein_coding Danio_rerio
ENSDARG00000091024 pparab peroxisome proliferator activated receptor alpha b protein_coding Danio_rerio
ENSG00000186951 PPARA peroxisome proliferator-activated receptor alpha protein_coding Homo_sapiens

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