C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: B cell leukemia/lymphoma 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022508 Bcl6 10090 - 16:23965052-23988852 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000023151 Bcl6-001 23965052-23988852 protein_coding
  ENSMUST00000135352 Bcl6-002 23967694-23972380 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000023151ENSMUST00000135352
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000023151 19.492±14.49 18.436±3.02 7.870±0.70 2.253±0.97 13.367±4.54 4.558±0.13 5.598±2.13 5.698±0.24 1.021±0.89 14.086±0.68 13.936±7.89 7.609±2.71 2.586±1.59 0.910±0.43
ENSMUST00000135352 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.605±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00003X CIL_00003X_0002 CGP 16:23925548-23988852
CIL_0003Y6 CIL_0003Y6_0003 CGP 16:23965052-24992576

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000060 IEA protein import into nucleus, translocation
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000902 IGI cell morphogenesis
GO:0000977 IDA RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227 IDA RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001953 IMP negative regulation of cell-matrix adhesion
GO:0002467 IMP germinal center formation
GO:0002829 IGI negative regulation of type 2 immune response
GO:0003677 IDA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005657 IEA replication fork
GO:0006351 IEA transcription, DNA-templated
GO:0006954 IEA inflammatory response
GO:0006974 IEA cellular response to DNA damage stimulus
GO:0007266 IGI Rho protein signal transduction
GO:0007283 IMP spermatogenesis
GO:0008104 IMP protein localization
GO:0008285 IMP negative regulation of cell proliferation
GO:0030036 IMP actin cytoskeleton organization
GO:0030183 IGI B cell differentiation
GO:0030308 IEA negative regulation of cell growth
GO:0030890 IMP positive regulation of B cell proliferation
GO:0031065 IGI positive regulation of histone deacetylation
GO:0031490 IDA chromatin DNA binding
GO:0032319 IMP regulation of Rho GTPase activity
GO:0032764 IMP negative regulation of mast cell cytokine production
GO:0035024 IMP negative regulation of Rho protein signal transduction
GO:0042092 IMP type 2 immune response
GO:0042127 IMP regulation of cell proliferation
GO:0043065 IEA positive regulation of apoptotic process
GO:0043066 IMP negative regulation of apoptotic process
GO:0043380 IMP regulation of memory T cell differentiation
GO:0043565 IDA sequence-specific DNA binding
GO:0045596 IMP negative regulation of cell differentiation
GO:0045629 IGI negative regulation of T-helper 2 cell differentiation
GO:0045666 IDA positive regulation of neuron differentiation
GO:0045746 IGI negative regulation of Notch signaling pathway
GO:0045892 IEA negative regulation of transcription, DNA-templated
GO:0046872 IEA metal ion binding
GO:0048294 IGI negative regulation of isotype switching to IgE isotypes
GO:0048821 IMP erythrocyte development
GO:0050727 IMP regulation of inflammatory response
GO:0051272 IMP positive regulation of cellular component movement
GO:2000773 IMP negative regulation of cellular senescence

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000069295 bcl6ab B-cell CLL/lymphoma 6a, genome duplicate b protein_coding Danio_rerio
ENSDARG00000070864 bcl6a B-cell CLL/lymphoma 6a (zinc finger protein 51) protein_coding Danio_rerio
ENSG00000113916 BCL6 B-cell CLL/lymphoma 6 protein_coding Homo_sapiens

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