C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: B-cell CLL/lymphoma 6
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000113916 BCL6 9606 - 3:187721377-187745727 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000232014 BCL6-004 187722398-187736569 protein_coding
  ENST00000406870 BCL6-001 187721377-187745727 protein_coding
  ENST00000419510 BCL6-003 187721387-187737088 nonsense_mediated_decay
  ENST00000430339 BCL6-008 187731727-187734947 protein_coding
  ENST00000438077 BCL6-007 187731780-187737944 protein_coding
  ENST00000450123 BCL6-010 187722432-187734882 protein_coding
  ENST00000470319 BCL6-005 187734445-187745472 retained_intron
  ENST00000479110 BCL6-011 187724569-187725623 retained_intron
  ENST00000480458 BCL6-009 187731765-187745437 processed_transcript
  ENST00000496823 BCL6-006 187736187-187745459 processed_transcript
  ENST00000621333 BCL6-201 187721377-187745725 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdrenalBladderBrainBreastColonHeartLiverLungMuscleOvaryPlacentaTestisENST00000232014ENST00000406870ENST00000419510ENST00000450123
Transcript ID Adrenal Bladder Brain Breast Colon Heart Liver Lung Muscle Ovary Placenta Testis
ENST00000232014 N/A N/A N/A 1.984±0.00 N/A N/A N/A 2.000±0.00 4.071±0.00 1.578±0.00 0.954±0.00 N/A
ENST00000406870 2.270±0.00 0.897±0.00 2.048±1.39 N/A 5.238±0.00 N/A 2.376±0.00 N/A N/A 3.229±2.59 N/A 4.433±2.94
ENST00000419510 N/A N/A 1.441±1.02 N/A N/A N/A 1.147±0.15 1.464±0.00 17.094±0.00 0.804±0.00 N/A 1.719±0.00
ENST00000450123 5.766±0.00 N/A 9.885±0.00 N/A N/A 10.091±0.00 N/A 25.868±0.00 25.728±21.50 8.064±1.91 N/A 4.840±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00003X CIL_00003X_0001 CGP 3:187698259-187745727
CIL_0003Y6 CIL_0003Y6_0002 CGP 3:187721377-188890671

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000060 IGI protein import into nucleus, translocation
GO:0000122 IDA negative regulation of transcription from RNA polymerase II promoter
GO:0000902 IEA cell morphogenesis
GO:0000977 IEA RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227 IEA RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001953 IEA negative regulation of cell-matrix adhesion
GO:0002467 IEA germinal center formation
GO:0002634 NAS regulation of germinal center formation
GO:0002829 IEA negative regulation of type 2 immune response
GO:0002903 NAS negative regulation of B cell apoptotic process
GO:0003677 IEA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IMP sequence-specific DNA binding transcription factor activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005657 IDA replication fork
GO:0006351 IEA transcription, DNA-templated
GO:0006954 IEA inflammatory response
GO:0006974 IDA cellular response to DNA damage stimulus
GO:0007266 IEA Rho protein signal transduction
GO:0007283 IEA spermatogenesis
GO:0008104 IEA protein localization
GO:0008285 IEA negative regulation of cell proliferation
GO:0030036 IEA actin cytoskeleton organization
GO:0030183 IEA B cell differentiation
GO:0030308 IDA negative regulation of cell growth
GO:0030890 IEA positive regulation of B cell proliferation
GO:0031065 IEA positive regulation of histone deacetylation
GO:0031490 IEA chromatin DNA binding
GO:0032319 IEA regulation of Rho GTPase activity
GO:0032764 IEA negative regulation of mast cell cytokine production
GO:0035024 IEA negative regulation of Rho protein signal transduction
GO:0042092 IEA type 2 immune response
GO:0042127 IEA regulation of cell proliferation
GO:0043065 IDA positive regulation of apoptotic process
GO:0043066 IEA negative regulation of apoptotic process
GO:0043380 IEA regulation of memory T cell differentiation
GO:0043565 IDA sequence-specific DNA binding
GO:0045596 IEA negative regulation of cell differentiation
GO:0045629 IEA negative regulation of T-helper 2 cell differentiation
GO:0045666 IEA positive regulation of neuron differentiation
GO:0045746 IEA negative regulation of Notch signaling pathway
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0046872 IEA metal ion binding
GO:0048294 IEA negative regulation of isotype switching to IgE isotypes
GO:0048821 IEA erythrocyte development
GO:0050727 IEA regulation of inflammatory response
GO:0050776 NAS regulation of immune response
GO:0051272 IEA positive regulation of cellular component movement
GO:2000773 IEA negative regulation of cellular senescence

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000069295 bcl6ab B-cell CLL/lymphoma 6a, genome duplicate b protein_coding Danio_rerio
ENSDARG00000070864 bcl6a B-cell CLL/lymphoma 6a (zinc finger protein 51) protein_coding Danio_rerio
ENSMUSG00000022508 Bcl6 B cell leukemia/lymphoma 6 protein_coding Mus_musculus

Loading