C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: discs, large homolog 1 (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022770 Dlg1 10090 + 16:31663443-31873356 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000023454 Dlg1-004 31664150-31872684 protein_coding
  ENSMUST00000064477 Dlg1-003 31664039-31873346 protein_coding
  ENSMUST00000100001 Dlg1-201 31663935-31873356 protein_coding
  ENSMUST00000115196 Dlg1-006 31754350-31872261 protein_coding
  ENSMUST00000115201 Dlg1-007 31663909-31871846 protein_coding
  ENSMUST00000115205 Dlg1-002 31663443-31873350 protein_coding
  ENSMUST00000130920 Dlg1-010 31836270-31857961 nonsense_mediated_decay
  ENSMUST00000131136 Dlg1-005 31791771-31842818 protein_coding
  ENSMUST00000132176 Dlg1-001 31663955-31873349 nonsense_mediated_decay
  ENSMUST00000137322 Dlg1-009 31829299-31836491 retained_intron
  ENSMUST00000138213 Dlg1-013 31853651-31863208 retained_intron
  ENSMUST00000140258 Dlg1-014 31867482-31871848 retained_intron
  ENSMUST00000147382 Dlg1-012 31838159-31852033 processed_transcript
  ENSMUST00000155847 Dlg1-011 31847323-31857916 retained_intron
  ENSMUST00000155958 Dlg1-008 31684266-31773787 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000023454ENSMUST00000064477ENSMUST00000100001ENSMUST00000115196ENSMUST00000115205ENSMUST00000131136ENSMUST00000132176
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000023454 2.157±0.81 2.344±0.00 6.107±0.00 3.541±0.84 2.469±0.38 2.300±0.78 2.213±0.15 3.154±0.48 1.966±0.51 3.176±0.59 N/A 2.573±0.56 5.259±1.27 1.768±0.53
ENSMUST00000064477 4.665±2.47 10.572±3.93 17.331±1.05 3.956±0.73 4.141±1.53 3.936±1.40 8.400±1.38 4.722±2.24 4.550±2.02 8.557±1.20 8.099±2.41 5.148±1.70 11.193±2.92 1.623±0.76
ENSMUST00000100001 1.530±0.00 2.798±0.01 N/A N/A 2.713±0.00 N/A N/A 3.375±1.18 1.546±0.00 2.275±0.66 N/A 3.336±0.99 N/A N/A
ENSMUST00000115196 N/A N/A N/A 3.837±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENSMUST00000115205 2.725±1.05 N/A 8.230±0.34 4.713±0.59 5.013±1.86 2.456±0.74 3.253±0.00 3.142±0.81 2.845±0.83 3.157±0.32 3.562±0.70 5.976±3.31 N/A 1.457±0.08
ENSMUST00000131136 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.085±0.00
ENSMUST00000132176 N/A N/A N/A 2.321±0.00 N/A N/A N/A N/A 2.118±0.87 N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003W7 CIL_0003W7_0002 CGP 16:31663443-31899020

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001657 IMP ureteric bud development
GO:0001658 IMP branching involved in ureteric bud morphogenesis
GO:0001771 IMP immunological synapse formation
GO:0001772 IDA immunological synapse
GO:0001935 ISS endothelial cell proliferation
GO:0002088 IMP lens development in camera-type eye
GO:0002369 IMP T cell cytokine production
GO:0005515 IPI protein binding
GO:0005605 IDA basal lamina
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005783 IEA endoplasmic reticulum
GO:0005794 IEA Golgi apparatus
GO:0005874 IEA microtubule
GO:0005886 IDA plasma membrane
GO:0005911 IEA cell-cell junction
GO:0005913 TAS cell-cell adherens junction
GO:0005923 IEA tight junction
GO:0007015 ISS actin filament organization
GO:0008022 IEA protein C-terminus binding
GO:0008104 IGI protein localization
GO:0008284 IMP positive regulation of cell proliferation
GO:0009898 IEA cytoplasmic side of plasma membrane
GO:0014069 IDA postsynaptic density
GO:0016323 IDA basolateral plasma membrane
GO:0016328 IDA lateral plasma membrane
GO:0016337 ISS single organismal cell-cell adhesion
GO:0019901 ISS protein kinase binding
GO:0019902 ISS phosphatase binding
GO:0030054 IDA cell junction
GO:0030432 IMP peristalsis
GO:0030838 IMP positive regulation of actin filament polymerization
GO:0030866 ISS cortical actin cytoskeleton organization
GO:0031253 IDA cell projection membrane
GO:0031434 IEA mitogen-activated protein kinase kinase binding
GO:0031579 IMP membrane raft organization
GO:0031594 IDA neuromuscular junction
GO:0031641 IMP regulation of myelination
GO:0032147 IMP activation of protein kinase activity
GO:0032947 IMP protein complex scaffold
GO:0033268 IDA node of Ranvier
GO:0035748 IDA myelin sheath abaxonal region
GO:0040018 TAS positive regulation of multicellular organism growth
GO:0042110 IMP T cell activation
GO:0042130 IMP negative regulation of T cell proliferation
GO:0042391 IGI regulation of membrane potential
GO:0042982 IGI amyloid precursor protein metabolic process
GO:0043219 IDA lateral loop
GO:0043268 IEA positive regulation of potassium ion transport
GO:0044325 IEA ion channel binding
GO:0045121 IDA membrane raft
GO:0045202 IDA synapse
GO:0045211 IEA postsynaptic membrane
GO:0045930 ISS negative regulation of mitotic cell cycle
GO:0048471 IEA perinuclear region of cytoplasm
GO:0048608 IMP reproductive structure development
GO:0048639 TAS positive regulation of developmental growth
GO:0048704 IMP embryonic skeletal system morphogenesis
GO:0048729 IMP tissue morphogenesis
GO:0048745 IMP smooth muscle tissue development
GO:0050680 IMP negative regulation of epithelial cell proliferation
GO:0051898 IMP negative regulation of protein kinase B signaling
GO:0060022 IMP hard palate development
GO:0070062 IEA extracellular vesicular exosome
GO:0070830 IEA tight junction assembly
GO:0072659 IEA protein localization to plasma membrane
GO:0090004 IEA positive regulation of establishment of protein localization to plasma membrane
GO:0097016 IEA L27 domain binding
GO:0097025 IEA MPP7-DLG1-LIN7 complex

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000009677 dlg1 discs, large (Drosophila) homolog 1 protein_coding Danio_rerio
ENSG00000075711 DLG1 discs, large homolog 1 (Drosophila) protein_coding Homo_sapiens

Loading