C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: discs, large homolog 1 (Drosophila)
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000075711 DLG1 9606 - 3:197042560-197299300 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000346964 DLG1-001 197042560-197298576 protein_coding
  ENST00000357674 DLG1-201 197042561-197298576 protein_coding
  ENST00000392380 DLG1-003 197149755-197297733 protein_coding
  ENST00000392381 DLG1-006 197078463-197298115 nonsense_mediated_decay
  ENST00000392382 DLG1-013 197044623-197298115 protein_coding
  ENST00000412364 DLG1-002 197282679-197297596 protein_coding
  ENST00000419227 DLG1-018 197069217-197298576 nonsense_mediated_decay
  ENST00000419354 DLG1-008 197043631-197299300 protein_coding
  ENST00000419553 DLG1-009 197194445-197298623 protein_coding
  ENST00000422288 DLG1-019 197044331-197297204 protein_coding
  ENST00000434148 DLG1-004 197296390-197297523 protein_coding
  ENST00000436682 DLG1-005 197194538-197297685 protein_coding
  ENST00000443183 DLG1-020 197044560-197183858 protein_coding
  ENST00000447466 DLG1-021 197116038-197183634 protein_coding
  ENST00000448528 DLG1-007 197044551-197298576 protein_coding
  ENST00000450955 DLG1-027 197044623-197297204 protein_coding
  ENST00000452595 DLG1-011 197044260-197184131 protein_coding
  ENST00000453607 DLG1-024 197140145-197260461 protein_coding
  ENST00000456699 DLG1-023 197149743-197297733 protein_coding
  ENST00000469073 DLG1-025 197194535-197226359 processed_transcript
  ENST00000469371 DLG1-012 197043033-197071003 retained_intron
  ENST00000470629 DLG1-026 197065709-197069482 retained_intron
  ENST00000471733 DLG1-017 197080478-197298631 retained_intron
  ENST00000475394 DLG1-016 197051577-197075871 retained_intron
  ENST00000477312 DLG1-014 197136324-197142799 retained_intron
  ENST00000485409 DLG1-010 197194337-197296889 processed_transcript
  ENST00000486877 DLG1-022 197282610-197297733 retained_intron
  ENST00000493937 DLG1-015 197080990-197085658 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000346964ENST00000357674ENST00000392381ENST00000392382ENST00000419354ENST00000422288ENST00000443183ENST00000448528ENST00000450955ENST00000452595ENST00000469371
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000346964 1.714±0.00 0.998±0.00 1.714±0.00 N/A N/A N/A N/A N/A N/A N/A 2.696±0.00 2.355±0.32 2.707±0.00 4.080±0.00
ENST00000357674 N/A 1.367±0.00 N/A 3.385±0.00 N/A 1.678±0.00 N/A 2.351±0.56 1.267±0.00 1.361±0.24 N/A 2.251±0.28 1.775±0.00 2.660±0.00
ENST00000392381 N/A N/A 2.239±0.00 N/A 4.784±0.00 8.271±0.00 N/A N/A 3.765±0.00 2.219±0.00 N/A 5.984±0.00 N/A N/A
ENST00000392382 N/A N/A N/A 11.075±0.00 N/A N/A N/A 2.487±0.00 N/A N/A N/A N/A N/A N/A
ENST00000419354 N/A N/A N/A N/A N/A N/A 1.078±0.00 3.925±0.00 2.422±0.00 1.416±0.00 1.298±0.00 3.690±0.00 2.457±0.00 3.676±0.00
ENST00000422288 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.842±0.00 3.519±0.00 N/A N/A
ENST00000443183 N/A N/A N/A 11.818±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000448528 N/A N/A N/A N/A N/A N/A N/A 3.160±0.00 N/A N/A N/A N/A N/A N/A
ENST00000450955 4.389±0.00 2.475±0.00 2.690±0.00 6.195±0.00 5.448±1.18 4.561±1.22 2.244±0.81 N/A 5.883±0.00 2.228±0.00 2.870±1.65 N/A 1.677±0.00 3.302±0.00
ENST00000452595 N/A N/A 2.863±0.00 7.044±0.00 6.450±0.00 6.803±0.00 N/A 1.608±0.00 2.708±0.00 3.584±0.00 N/A 7.098±0.00 N/A N/A
ENST00000469371 N/A N/A N/A 4.827±0.00 2.242±0.00 N/A N/A N/A N/A 0.931±0.00 N/A N/A N/A N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001657 IEA ureteric bud development
GO:0001658 IEA branching involved in ureteric bud morphogenesis
GO:0001771 IEA immunological synapse formation
GO:0001772 TAS immunological synapse
GO:0001935 IDA endothelial cell proliferation
GO:0002088 IEA lens development in camera-type eye
GO:0002369 IEA T cell cytokine production
GO:0004385 TAS guanylate kinase activity
GO:0004721 TAS phosphoprotein phosphatase activity
GO:0005515 IPI:IEA protein binding
GO:0005605 IEA basal lamina
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005783 IDA endoplasmic reticulum
GO:0005794 IDA Golgi apparatus
GO:0005829 TAS cytosol
GO:0005874 IDA microtubule
GO:0005886 TAS plasma membrane
GO:0005911 IDA cell-cell junction
GO:0005923 IDA tight junction
GO:0007015 IDA actin filament organization
GO:0007093 NAS mitotic cell cycle checkpoint
GO:0007163 TAS establishment or maintenance of cell polarity
GO:0007268 TAS synaptic transmission
GO:0007411 TAS axon guidance
GO:0008022 IPI protein C-terminus binding
GO:0008092 TAS cytoskeletal protein binding
GO:0008104 IEA protein localization
GO:0008284 IEA positive regulation of cell proliferation
GO:0009898 IDA cytoplasmic side of plasma membrane
GO:0014069 IEA postsynaptic density
GO:0014704 TAS intercalated disc
GO:0015459 NAS potassium channel regulator activity
GO:0016032 IEA viral process
GO:0016311 TAS dephosphorylation
GO:0016323 IDA basolateral plasma membrane
GO:0016328 IEA lateral plasma membrane
GO:0016337 IDA single organismal cell-cell adhesion
GO:0019901 IPI protein kinase binding
GO:0019902 IPI phosphatase binding
GO:0030054 IDA cell junction
GO:0030432 IEA peristalsis
GO:0030838 IEA positive regulation of actin filament polymerization
GO:0030866 IDA cortical actin cytoskeleton organization
GO:0031253 IEA cell projection membrane
GO:0031434 IPI mitogen-activated protein kinase kinase binding
GO:0031579 IEA membrane raft organization
GO:0031594 IEA neuromuscular junction
GO:0031641 IEA regulation of myelination
GO:0032147 IEA activation of protein kinase activity
GO:0032947 IEA protein complex scaffold
GO:0033268 IEA node of Ranvier
GO:0035748 IEA myelin sheath abaxonal region
GO:0042110 IEA T cell activation
GO:0042130 IEA negative regulation of T cell proliferation
GO:0042391 IDA regulation of membrane potential
GO:0042982 IEA amyloid precursor protein metabolic process
GO:0043219 IEA lateral loop
GO:0043268 IDA positive regulation of potassium ion transport
GO:0044325 IPI ion channel binding
GO:0045121 IEA membrane raft
GO:0045202 IEA synapse
GO:0045211 IEA postsynaptic membrane
GO:0045930 IMP negative regulation of mitotic cell cycle
GO:0046939 TAS nucleotide phosphorylation
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048608 IEA reproductive structure development
GO:0048704 IEA embryonic skeletal system morphogenesis
GO:0048729 IEA tissue morphogenesis
GO:0048745 IEA smooth muscle tissue development
GO:0050680 IEA negative regulation of epithelial cell proliferation
GO:0051898 IEA negative regulation of protein kinase B signaling
GO:0060022 IEA hard palate development
GO:0070062 IDA extracellular vesicular exosome
GO:0070830 IDA tight junction assembly
GO:0072659 IMP protein localization to plasma membrane
GO:0090004 IDA positive regulation of establishment of protein localization to plasma membrane
GO:0097016 IPI L27 domain binding
GO:0097025 IDA MPP7-DLG1-LIN7 complex
GO:1902305 TAS regulation of sodium ion transmembrane transport

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000009677 dlg1 discs, large (Drosophila) homolog 1 protein_coding Danio_rerio
ENSMUSG00000022770 Dlg1 discs, large homolog 1 (Drosophila) protein_coding Mus_musculus

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