C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Transcript Info
Description: p21 protein (Cdc42/Rac)-activated kinase 2
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000023467 Pak2-001 ENSMUSG00000022781 10090 - 16:32016290-32079342 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000023467
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000023467 14.785±4.34 15.193±2.68 10.437±4.95 11.991±6.50 14.461±4.46 13.956±1.58 5.204±0.55 11.178±0.43 5.963±1.24 19.097±1.31 3.402±0.27 18.508±2.70 15.751±7.39 4.338±1.14

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0003W8 CIL_0003W8_0002 CGP 16:32016290-32099738

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004674 ISS protein serine/threonine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0006468 ISO protein phosphorylation
GO:0016020 IEA membrane
GO:0016310 IEA phosphorylation
GO:0018105 IEA peptidyl-serine phosphorylation
GO:0019901 IEA protein kinase binding
GO:0030296 IEA protein tyrosine kinase activator activity
GO:0040008 IEA regulation of growth
GO:0042802 IEA identical protein binding
GO:0043066 IEA negative regulation of apoptotic process
GO:0046777 ISO protein autophosphorylation
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0061098 IEA positive regulation of protein tyrosine kinase activity
GO:2001238 IEA positive regulation of extrinsic apoptotic signaling pathway
GO:2001271 IEA negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSDART00000009560 pak1-201 protein_coding Danio_rerio 1.99965e-42 180
ENST00000262836 PAK3-201 protein_coding Homo_sapiens 0 531
ENST00000327134 PAK2-001 protein_coding Homo_sapiens 0 2466
ENST00000360648 PAK3-202 protein_coding Homo_sapiens 0 531
ENST00000372007 PAK3-001 protein_coding Homo_sapiens 0 531
ENST00000372010 PAK3-002 protein_coding Homo_sapiens 0 531
ENST00000417227 PAK3-203 protein_coding Homo_sapiens 0 531
ENST00000425146 PAK3-204 protein_coding Homo_sapiens 0 531
ENST00000426668 PAK2-004 protein_coding Homo_sapiens 0 750
ENST00000446737 PAK3-205 protein_coding Homo_sapiens 0 531
ENST00000518291 PAK3-007 protein_coding Homo_sapiens 0 531
ENST00000519681 PAK3-006 protein_coding Homo_sapiens 0 531
ENST00000556425 RP11-32B5.1-001 processed_pseudogene Homo_sapiens 0 1836
ENST00000615005 AC136352.8-201 pseudogene Homo_sapiens 0 1916
ENST00000615953 AC136352.2-201 pseudogene Homo_sapiens 0 1916
ENST00000620137 PAK3-206 protein_coding Homo_sapiens 0 531

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