C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: tyrosine kinase, non-receptor, 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022791 Tnk2 10090 + 16:32643874-32683493 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000115120 Tnk2-004 32673156-32683493 protein_coding
  ENSMUST00000115121 Tnk2-016 32673192-32680133 protein_coding
  ENSMUST00000115122 Tnk2-015 32673154-32679466 protein_coding
  ENSMUST00000115123 Tnk2-003 32644826-32683492 protein_coding
  ENSMUST00000115124 Tnk2-001 32644673-32683493 protein_coding
  ENSMUST00000115125 Tnk2-005 32644643-32683493 protein_coding
  ENSMUST00000115126 Tnk2-002 32644643-32683493 protein_coding
  ENSMUST00000124585 Tnk2-009 32644291-32663888 processed_transcript
  ENSMUST00000131238 Tnk2-007 32673178-32679680 protein_coding
  ENSMUST00000137044 Tnk2-013 32668240-32671634 processed_transcript
  ENSMUST00000145627 Tnk2-010 32643874-32668279 processed_transcript
  ENSMUST00000150383 Tnk2-011 32657023-32668271 processed_transcript
  ENSMUST00000152361 Tnk2-008 32673199-32679882 protein_coding
  ENSMUST00000156614 Tnk2-012 32658925-32668263 processed_transcript
  ENSMUST00000164358 Tnk2-014 32644959-32668292 processed_transcript
  ENSMUST00000168506 Tnk2-017 32673195-32679064 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000115120ENSMUST00000115121ENSMUST00000115123ENSMUST00000115124ENSMUST00000115125ENSMUST00000115126ENSMUST00000137044
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000115120 6.006±0.00 5.289±1.26 21.097±1.28 16.836±6.59 15.197±2.48 34.332±7.93 N/A 2.344±0.48 3.239±1.39 5.727±0.52 5.413±2.50 8.983±2.39 12.074±9.50 N/A
ENSMUST00000115121 N/A N/A N/A N/A 18.906±0.00 N/A N/A N/A 2.834±0.00 N/A N/A 13.189±1.33 N/A N/A
ENSMUST00000115123 13.298±0.25 7.974±1.03 4.000±0.00 8.185±1.17 11.693±5.12 8.392±1.47 3.412±0.93 4.803±0.69 2.712±1.67 12.033±2.05 5.017±2.40 11.194±3.65 1.557±0.00 2.691±0.66
ENSMUST00000115124 N/A N/A 10.143±1.74 19.610±15.75 N/A N/A 1.420±0.17 1.232±0.00 2.028±0.98 N/A 6.207±1.19 9.467±0.00 3.215±2.53 1.373±0.22
ENSMUST00000115125 4.219±0.58 3.912±0.00 5.014±0.08 14.373±9.12 4.120±1.46 N/A 2.083±0.64 2.282±0.59 1.750±1.00 5.734±0.57 N/A 5.276±0.96 10.196±5.51 2.482±0.14
ENSMUST00000115126 N/A N/A N/A 15.582±6.10 N/A N/A 0.926±0.25 N/A N/A N/A 3.856±1.36 N/A N/A N/A
ENSMUST00000137044 N/A N/A N/A N/A 4.736±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0008QR CIL_0008QR_0002 VISTA 16:32268412-32870796
CIL_0007CJ CIL_0007CJ_0003 CGP 16:32608920-32683493

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004674 IEA protein serine/threonine kinase activity
GO:0004712 IEA protein serine/threonine/tyrosine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0005154 IEA epidermal growth factor receptor binding
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005737 IEA cytoplasm
GO:0005768 IDA endosome
GO:0005886 IEA plasma membrane
GO:0005905 IEA coated pit
GO:0006897 IEA endocytosis
GO:0016020 IEA membrane
GO:0016301 IEA kinase activity
GO:0016310 IEA phosphorylation
GO:0018108 IEA peptidyl-tyrosine phosphorylation
GO:0030054 IEA cell junction
GO:0030136 IEA clathrin-coated vesicle
GO:0030424 IDA axon
GO:0030425 IDA dendrite
GO:0030426 IDA growth cone
GO:0031410 IEA cytoplasmic vesicle
GO:0043025 IDA neuronal cell body
GO:0046872 IEA metal ion binding
GO:0050699 IPI WW domain binding
GO:0050731 IEA positive regulation of peptidyl-tyrosine phosphorylation
GO:0070436 IEA Grb2-EGFR complex
GO:2000369 IEA regulation of clathrin-mediated endocytosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062261 CT476804.2 Uncharacterized protein protein_coding Danio_rerio
ENSDARG00000075716 tnk2b tyrosine kinase, non-receptor, 2b protein_coding Danio_rerio
ENSDARG00000090646 tnk2a tyrosine kinase, non-receptor, 2a protein_coding Danio_rerio
ENSG00000061938 TNK2 tyrosine kinase, non-receptor, 2 protein_coding Homo_sapiens

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