C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: amyloid beta (A4) precursor protein
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000022892 App 10090 - 16:84954440-85173707 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000005406 App-201 84954440-85173707 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000005406
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000005406 64.615±9.94 30.948±5.44 44.431±0.42 236.257±114.06 47.578±8.94 68.194±31.11 12.799±5.19 168.121±31.37 5.136±2.18 135.970±45.89 6.732±1.36 57.435±46.07 39.715±22.18 14.322±5.87

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0000MM CIL_0000MM_0003 CGP 16:84834925-85173707
CIL_0000RE CIL_0000RE_0002 CGP 16:84954440-85553397

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001967 IGI suckling behavior
GO:0003677 IDA DNA binding
GO:0005102 IEA receptor binding
GO:0005515 IPI protein binding
GO:0005615 IEA extracellular space
GO:0005641 IEA nuclear envelope lumen
GO:0005737 IDA cytoplasm
GO:0005768 IEA endosome
GO:0005794 IDA Golgi apparatus
GO:0005886 IDA plasma membrane
GO:0005905 IEA coated pit
GO:0005911 IDA cell-cell junction
GO:0006378 IDA mRNA polyadenylation
GO:0006417 IDA regulation of translation
GO:0006468 IMP protein phosphorylation
GO:0006878 IMP cellular copper ion homeostasis
GO:0006897 IMP endocytosis
GO:0006979 IGI response to oxidative stress
GO:0007155 IEA cell adhesion
GO:0007176 IGI regulation of epidermal growth factor-activated receptor activity
GO:0007219 IEA Notch signaling pathway
GO:0007409 IMP axonogenesis
GO:0007617 IGI mating behavior
GO:0007626 IGI locomotory behavior
GO:0008088 IMP axon cargo transport
GO:0008201 IEA heparin binding
GO:0008203 IGI cholesterol metabolic process
GO:0008344 IMP adult locomotory behavior
GO:0008542 IMP visual learning
GO:0009986 IEA cell surface
GO:0010468 IDA regulation of gene expression
GO:0010951 IEA negative regulation of endopeptidase activity
GO:0010952 IEA positive regulation of peptidase activity
GO:0010971 IMP positive regulation of G2/M transition of mitotic cell cycle
GO:0016020 IDA membrane
GO:0016021 IDA integral component of membrane
GO:0016199 IMP axon midline choice point recognition
GO:0016322 IMP neuron remodeling
GO:0016358 IMP dendrite development
GO:0016504 IEA peptidase activator activity
GO:0019899 IEA enzyme binding
GO:0030134 IDA ER to Golgi transport vesicle
GO:0030198 IGI extracellular matrix organization
GO:0030424 IDA axon
GO:0030900 IMP forebrain development
GO:0031175 IDA neuron projection development
GO:0031410 IDA cytoplasmic vesicle
GO:0031594 IDA neuromuscular junction
GO:0033130 IEA acetylcholine receptor binding
GO:0035235 IMP ionotropic glutamate receptor signaling pathway
GO:0035253 IDA ciliary rootlet
GO:0040014 IMP regulation of multicellular organism growth
GO:0042802 IEA identical protein binding
GO:0043005 IDA neuron projection
GO:0043197 IEA dendritic spine
GO:0043198 IEA dendritic shaft
GO:0043231 IEA intracellular membrane-bounded organelle
GO:0043235 ISO receptor complex
GO:0043393 IGI regulation of protein binding
GO:0045121 IEA membrane raft
GO:0045177 IDA apical part of cell
GO:0045202 IEA synapse
GO:0045665 IDA negative regulation of neuron differentiation
GO:0045931 IMP positive regulation of mitotic cell cycle
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046914 IEA transition metal ion binding
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048669 IGI collateral sprouting in absence of injury
GO:0050803 IMP regulation of synapse structure and activity
GO:0050885 IGI neuromuscular process controlling balance
GO:0051124 IGI synaptic growth at neuromuscular junction
GO:0051233 IDA spindle midzone
GO:0051260 ISO protein homooligomerization
GO:0051402 IGI neuron apoptotic process
GO:0051425 IEA PTB domain binding
GO:0051563 IGI smooth endoplasmic reticulum calcium ion homeostasis
GO:0070062 IEA extracellular vesicular exosome
GO:0070851 IEA growth factor receptor binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000055543 appb amyloid beta (A4) precursor protein b protein_coding Danio_rerio
ENSDARG00000059036 appa amyloid beta (A4) precursor protein a protein_coding Danio_rerio
ENSG00000142192 APP amyloid beta (A4) precursor protein protein_coding Homo_sapiens

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