C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: complement component 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000024164 C3 10090 - 17:57203970-57228136 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000024988 C3-001 57203970-57228136 protein_coding
  ENSMUST00000176457 C3-003 57215788-57219972 processed_transcript
  ENSMUST00000177046 C3-002 57206217-57228003 protein_coding
  ENSMUST00000177425 C3-004 57204007-57222827 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000024988ENSMUST00000177425
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000024988 130.240±13.44 336.523±175.44 38.094±0.74 0.389±0.42 148.051±34.26 21.297±4.14 32.861±9.04 25.855±4.13 1233.565±942.69 100.128±8.59 4.093±1.32 123.853±51.06 10.762±18.58 3.618±1.33
ENSMUST00000177425 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 31.434±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004C9 CIL_0004C9_0002 CGP 17:57189492-57228136
CIL_00010U CIL_00010U_0002 CGP 17:57203970-57247641

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001798 IMP positive regulation of type IIa hypersensitivity
GO:0001934 ISS positive regulation of protein phosphorylation
GO:0001970 IMP positive regulation of activation of membrane attack complex
GO:0004866 IEA endopeptidase inhibitor activity
GO:0005515 IPI protein binding
GO:0006631 IEA fatty acid metabolic process
GO:0006954 IEA inflammatory response
GO:0006956 IDA complement activation
GO:0006957 IEA complement activation, alternative pathway
GO:0006958 IEA complement activation, classical pathway
GO:0010575 IEA positive regulation vascular endothelial growth factor production
GO:0010828 ISS positive regulation of glucose transport
GO:0010866 ISS regulation of triglyceride biosynthetic process
GO:0010884 ISS positive regulation of lipid storage
GO:0010951 IEA negative regulation of endopeptidase activity
GO:0031715 ISS C5L2 anaphylatoxin chemotactic receptor binding
GO:0045745 ISS positive regulation of G-protein coupled receptor protein signaling pathway
GO:0045766 IMP positive regulation of angiogenesis
GO:0050766 IMP positive regulation of phagocytosis
GO:0070062 IEA extracellular vesicular exosome
GO:0072562 IEA blood microparticle
GO:2000427 IEA positive regulation of apoptotic cell clearance

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000001818 C3 (1 of 9) complement component 3 protein_coding Danio_rerio
ENSDARG00000012694 c3a complement component c3a protein_coding Danio_rerio
ENSDARG00000052207 c3c complement component c3c protein_coding Danio_rerio
ENSDARG00000087359 c3b complement component c3b protein_coding Danio_rerio
ENSDARG00000093068 C3 (8 of 9) complement component 3 protein_coding Danio_rerio
ENSDARG00000093198 C3 (9 of 9) complement component 3 protein_coding Danio_rerio
ENSG00000125730 C3 complement component 3 protein_coding Homo_sapiens

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