C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: complement component 3
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000125730 C3 9606 - 19:6677704-6730562 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000245907 C3-001 6677704-6720682 protein_coding
  ENST00000594005 C3-009 6696614-6697715 retained_intron
  ENST00000594270 C3-017 6712280-6713315 processed_transcript
  ENST00000594936 C3-006 6718034-6720650 retained_intron
  ENST00000595577 C3-005 6712316-6714351 retained_intron
  ENST00000596179 C3-012 6684233-6684632 retained_intron
  ENST00000596238 C3-011 6684560-6686376 retained_intron
  ENST00000596548 C3-018 6680159-6685038 protein_coding
  ENST00000597442 C3-004 6712307-6713788 processed_transcript
  ENST00000598805 C3-010 6686289-6693083 retained_intron
  ENST00000599668 C3-013 6677867-6680151 processed_transcript
  ENST00000599899 C3-002 6677841-6683360 retained_intron
  ENST00000600744 C3-003 6718247-6730562 protein_coding
  ENST00000600763 C3-007 6709756-6710957 retained_intron
  ENST00000601008 C3-015 6677897-6690712 protein_coding
  ENST00000601475 C3-016 6677835-6678330 retained_intron
  ENST00000602053 C3-008 6697662-6702872 retained_intron
  ENST00000602229 C3-014 6677864-6679201 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000245907ENST00000594936ENST00000596238ENST00000596548ENST00000599668ENST00000601475
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000245907 95.568±0.00 65.684±0.00 1.378±0.00 17.152±3.85 51.824±2.36 80.111±58.71 49.977±35.64 809.728±771.87 782.964±775.73 67.697±11.63 6.205±1.21 189.318±269.00 22.463±3.49 42.486±38.46
ENST00000594936 N/A N/A 3.670±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000596238 N/A N/A 4.117±0.00 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000596548 N/A N/A N/A N/A N/A N/A N/A N/A 2656.260±0.00 N/A N/A N/A N/A N/A
ENST00000599668 N/A N/A N/A N/A N/A N/A N/A 196.021±0.00 4314.630±0.00 N/A N/A N/A N/A N/A
ENST00000601475 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 121.649±0.00 N/A 56.681±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004C9 CIL_0004C9_0001 CGP 19:6661253-6730562
CIL_00010U CIL_00010U_0001 CGP 19:6677704-6737603

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001798 IEA positive regulation of type IIa hypersensitivity
GO:0001934 IDA positive regulation of protein phosphorylation
GO:0001970 IEA positive regulation of activation of membrane attack complex
GO:0004866 IEA endopeptidase inhibitor activity
GO:0005102 TAS receptor binding
GO:0005515 IPI:IEA protein binding
GO:0005576 TAS:IEA extracellular region
GO:0005615 IDA:IEA extracellular space
GO:0005886 TAS plasma membrane
GO:0006631 IEA fatty acid metabolic process
GO:0006954 IEA inflammatory response
GO:0006955 TAS immune response
GO:0006956 IMP complement activation
GO:0006957 TAS complement activation, alternative pathway
GO:0006958 IEA complement activation, classical pathway
GO:0007165 TAS signal transduction
GO:0007186 TAS G-protein coupled receptor signaling pathway
GO:0010575 IDA positive regulation vascular endothelial growth factor production
GO:0010828 IDA positive regulation of glucose transport
GO:0010866 IDA regulation of triglyceride biosynthetic process
GO:0010884 IDA positive regulation of lipid storage
GO:0010951 IEA negative regulation of endopeptidase activity
GO:0030449 TAS regulation of complement activation
GO:0031715 IDA C5L2 anaphylatoxin chemotactic receptor binding
GO:0045087 TAS innate immune response
GO:0045745 IDA positive regulation of G-protein coupled receptor protein signaling pathway
GO:0045766 IEA positive regulation of angiogenesis
GO:0050766 IEA positive regulation of phagocytosis
GO:0050776 TAS regulation of immune response
GO:0070062 IDA extracellular vesicular exosome
GO:0072562 IDA blood microparticle
GO:2000427 IMP positive regulation of apoptotic cell clearance

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000001818 C3 (1 of 9) complement component 3 protein_coding Danio_rerio
ENSDARG00000012694 c3a complement component c3a protein_coding Danio_rerio
ENSDARG00000052207 c3c complement component c3c protein_coding Danio_rerio
ENSDARG00000087359 c3b complement component c3b protein_coding Danio_rerio
ENSDARG00000093068 C3 (8 of 9) complement component 3 protein_coding Danio_rerio
ENSDARG00000093198 C3 (9 of 9) complement component 3 protein_coding Danio_rerio
ENSMUSG00000024164 C3 complement component 3 protein_coding Mus_musculus

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