C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: MAP/microtubule affinity-regulating kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000024969 Mark2 10090 - 19:7275396-7341860 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000025921 Mark2-006 7276759-7295447 protein_coding
  ENSMUST00000032557 Mark2-001 7275396-7341819 protein_coding
  ENSMUST00000051711 Mark2-201 7276759-7341588 protein_coding
  ENSMUST00000163345 Mark2-020 7279160-7281941 protein_coding
  ENSMUST00000164129 Mark2-018 7281037-7283110 nonsense_mediated_decay
  ENSMUST00000164205 Mark2-003 7276733-7341799 protein_coding
  ENSMUST00000165286 Mark2-002 7276849-7341804 protein_coding
  ENSMUST00000165881 Mark2-016 7277445-7283178 protein_coding
  ENSMUST00000165965 Mark2-005 7276759-7341433 protein_coding
  ENSMUST00000165989 Mark2-010 7290337-7341642 protein_coding
  ENSMUST00000166461 Mark2-019 7276849-7283050 protein_coding
  ENSMUST00000167767 Mark2-017 7277280-7283065 protein_coding
  ENSMUST00000168324 Mark2-012 7290666-7341812 protein_coding
  ENSMUST00000168852 Mark2-014 7284757-7287363 retained_intron
  ENSMUST00000168872 Mark2-008 7277090-7341221 protein_coding
  ENSMUST00000169541 Mark2-013 7287337-7341604 protein_coding
  ENSMUST00000170768 Mark2-015 7283137-7284778 retained_intron
  ENSMUST00000171044 Mark2-021 7276852-7278094 retained_intron
  ENSMUST00000171352 Mark2-009 7278502-7283517 protein_coding
  ENSMUST00000171393 Mark2-011 7285820-7341860 protein_coding
  ENSMUST00000171721 Mark2-007 7276759-7341192 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000025921ENSMUST00000032557ENSMUST00000164205ENSMUST00000165965ENSMUST00000167767ENSMUST00000168872ENSMUST00000169541ENSMUST00000171352ENSMUST00000171721
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000025921 N/A N/A N/A N/A N/A 12.311±1.38 N/A N/A N/A N/A N/A N/A 3.727±0.07 N/A
ENSMUST00000032557 7.814±0.81 8.688±0.64 12.538±2.43 12.586±1.69 9.285±2.56 11.957±2.91 4.462±2.23 8.725±1.38 2.632±0.90 9.888±3.46 3.881±1.51 11.854±2.13 5.256±1.53 8.145±6.15
ENSMUST00000164205 N/A N/A N/A N/A N/A N/A N/A N/A 2.757±0.00 N/A N/A N/A N/A N/A
ENSMUST00000165965 5.710±0.72 N/A 7.736±1.15 20.314±16.37 N/A N/A N/A N/A 2.918±0.93 N/A N/A 11.556±5.10 10.458±5.67 7.294±0.00
ENSMUST00000167767 N/A N/A N/A 45.524±0.00 N/A N/A N/A N/A N/A N/A N/A 61.591±0.00 42.241±0.06 45.743±0.00
ENSMUST00000168872 N/A N/A N/A N/A N/A N/A 2.865±0.00 N/A N/A N/A 2.369±0.00 N/A 5.880±0.00 8.192±0.00
ENSMUST00000169541 N/A 20.883±5.42 N/A N/A N/A N/A N/A N/A N/A N/A N/A 18.416±0.00 N/A N/A
ENSMUST00000171352 3.787±0.53 5.014±0.39 N/A 4.641±0.22 7.346±2.17 9.160±0.00 1.665±0.11 N/A 1.065±0.10 5.013±0.38 2.023±0.01 6.858±0.72 N/A N/A
ENSMUST00000171721 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 8.128±1.39 N/A

Conserved Regions

Gene is not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 ISS magnesium ion binding
GO:0001764 ISS neuron migration
GO:0004674 ISS protein serine/threonine kinase activity
GO:0005515 IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IDA nucleus
GO:0005884 ISS actin filament
GO:0005886 ISS plasma membrane
GO:0006468 ISS protein phosphorylation
GO:0008289 IEA lipid binding
GO:0010976 ISS positive regulation of neuron projection development
GO:0016020 ISS membrane
GO:0016055 IEA Wnt signaling pathway
GO:0016328 ISS lateral plasma membrane
GO:0030010 ISS establishment of cell polarity
GO:0035556 ISS intracellular signal transduction
GO:0044822 IEA poly(A) RNA binding
GO:0045180 IDA basal cortex
GO:0045197 ISS establishment or maintenance of epithelial cell apical/basal polarity
GO:0046777 ISS protein autophosphorylation
GO:0050321 ISS tau-protein kinase activity
GO:0050770 ISS regulation of axonogenesis
GO:0051493 ISS regulation of cytoskeleton organization
GO:0097427 ISS microtubule bundle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000032458 mark2b MAP/microtubule affinity-regulating kinase 2b protein_coding Danio_rerio
ENSDARG00000079905 mark2a MAP/microtubule affinity-regulating kinase 2a protein_coding Danio_rerio
ENSG00000072518 MARK2 MAP/microtubule affinity-regulating kinase 2 protein_coding Homo_sapiens

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