C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: MAP/microtubule affinity-regulating kinase 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000072518 MARK2 9606 + 11:63838928-63911019 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000350490 MARK2-009 63839093-63909596 protein_coding
  ENST00000361128 MARK2-010 63839005-63909579 protein_coding
  ENST00000377810 MARK2-201 63838928-63911019 protein_coding
  ENST00000402010 MARK2-202 63838928-63911019 protein_coding
  ENST00000408948 MARK2-016 63895186-63909255 protein_coding
  ENST00000425897 MARK2-012 63895204-63909237 protein_coding
  ENST00000502399 MARK2-002 63839295-63909573 protein_coding
  ENST00000508192 MARK2-001 63839005-63909484 protein_coding
  ENST00000509502 MARK2-003 63888547-63909398 protein_coding
  ENST00000512060 MARK2-005 63888696-63895226 protein_coding
  ENST00000513765 MARK2-006 63895155-63909591 protein_coding
  ENST00000535116 MARK2-011 63902687-63903403 retained_intron
  ENST00000540169 MARK2-015 63869276-63898793 protein_coding
  ENST00000543220 MARK2-013 63849963-63899924 protein_coding
  ENST00000543674 MARK2-014 63868470-63895275 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000350490ENST00000361128ENST00000377810ENST00000402010ENST00000408948ENST00000425897ENST00000502399ENST00000508192ENST00000509502ENST00000513765
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000350490 N/A N/A N/A 0.858±0.00 N/A 1.849±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000361128 N/A N/A N/A N/A N/A N/A N/A 1.421±0.00 N/A N/A N/A N/A N/A N/A
ENST00000377810 N/A N/A N/A 2.269±1.56 1.953±0.00 N/A 2.176±0.00 1.342±0.99 1.361±0.00 4.803±0.00 4.973±0.00 3.755±1.22 3.429±0.59 1.113±0.00
ENST00000402010 1.463±0.00 N/A N/A 1.610±0.00 2.249±0.00 1.110±0.00 N/A N/A N/A 2.330±0.00 N/A 5.081±0.23 2.492±1.28 N/A
ENST00000408948 N/A N/A 0.639±0.00 N/A 1.396±0.00 N/A N/A N/A N/A N/A N/A 3.364±1.87 N/A N/A
ENST00000425897 3.348±0.00 4.455±0.00 N/A 4.601±0.00 N/A 1.384±0.00 N/A 3.272±0.00 N/A N/A N/A 3.337±2.25 7.267±0.00 5.721±1.85
ENST00000502399 N/A 2.349±0.00 1.542±0.00 1.891±0.00 0.545±0.00 1.812±0.00 N/A 2.828±0.00 2.053±0.00 0.562±0.00 1.445±0.00 0.793±0.00 N/A 1.670±0.00
ENST00000508192 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.517±0.00 N/A N/A N/A N/A
ENST00000509502 N/A N/A N/A N/A N/A N/A 0.285±0.00 N/A N/A N/A N/A N/A N/A N/A
ENST00000513765 N/A N/A N/A N/A N/A N/A N/A N/A N/A 0.854±0.00 1.960±0.00 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0004M6 CIL_0004M6_0002 CGP 11:63838928-63916844

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 IDA magnesium ion binding
GO:0000422 NAS mitochondrion degradation
GO:0001764 ISS neuron migration
GO:0004672 IEA protein kinase activity
GO:0004674 IDA protein serine/threonine kinase activity
GO:0004713 IEA protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IEA:IDA ATP binding
GO:0005634 IEA nucleus
GO:0005739 NAS mitochondrion
GO:0005884 IDA actin filament
GO:0005886 IDA plasma membrane
GO:0006468 IDA:IEA protein phosphorylation
GO:0008289 IEA lipid binding
GO:0010976 IDA positive regulation of neuron projection development
GO:0016020 IMP membrane
GO:0016055 IEA Wnt signaling pathway
GO:0016328 IDA lateral plasma membrane
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018107 TAS peptidyl-threonine phosphorylation
GO:0030010 IDA establishment of cell polarity
GO:0030295 TAS protein kinase activator activity
GO:0032147 TAS activation of protein kinase activity
GO:0035556 IDA intracellular signal transduction
GO:0044822 IDA poly(A) RNA binding
GO:0045180 IEA basal cortex
GO:0045197 IDA establishment or maintenance of epithelial cell apical/basal polarity
GO:0046777 ISS protein autophosphorylation
GO:0050321 ISS tau-protein kinase activity
GO:0050770 IMP regulation of axonogenesis
GO:0051493 ISS regulation of cytoskeleton organization
GO:0051646 NAS mitochondrion localization
GO:0097427 IDA microtubule bundle

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000032458 mark2b MAP/microtubule affinity-regulating kinase 2b protein_coding Danio_rerio
ENSDARG00000079905 mark2a MAP/microtubule affinity-regulating kinase 2a protein_coding Danio_rerio
ENSMUSG00000024969 Mark2 MAP/microtubule affinity-regulating kinase 2 protein_coding Mus_musculus

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