C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: SRY (sex determining region Y)-box 17
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000025902 Sox17 10090 - 1:4490928-4496413 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000027035 Sox17-201 4490928-4496413 protein_coding
  ENSMUST00000116652 Sox17-202 4491713-4496363 protein_coding

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000027035ENSMUST00000116652
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000027035 26.781±0.00 6.539±1.08 2.404±0.23 1.330±0.00 4.971±1.69 1.221±0.36 1.280±0.07 3.111±2.13 0.403±0.16 26.037±4.58 0.469±0.00 18.416±6.57 0.778±0.15 0.981±0.62
ENSMUST00000116652 23.432±12.03 27.742±8.06 4.566±0.06 3.637±1.55 5.142±2.65 1.363±0.45 1.318±0.00 6.562±4.13 1.350±0.85 13.440±0.00 N/A 42.072±14.64 7.642±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_00053S CIL_00053S_0002 CGP 1:4490928-4785739

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0000981 IDA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001525 IGI angiogenesis
GO:0001570 IGI vasculogenesis
GO:0001706 IEA endoderm formation
GO:0001828 IMP inner cell mass cellular morphogenesis
GO:0001947 IMP heart looping
GO:0003142 IMP cardiogenic plate morphogenesis
GO:0003143 IMP embryonic heart tube morphogenesis
GO:0003151 IGI outflow tract morphogenesis
GO:0003308 IMP negative regulation of Wnt signaling pathway involved in heart development
GO:0003677 IDA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003713 IDA transcription coactivator activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IEA transcription factor complex
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0007283 IDA spermatogenesis
GO:0007369 IMP gastrulation
GO:0007492 IMP endoderm development
GO:0007493 IDA endodermal cell fate determination
GO:0008013 IEA beta-catenin binding
GO:0008134 IEA transcription factor binding
GO:0010628 IMP positive regulation of gene expression
GO:0021903 IMP rostrocaudal neural tube patterning
GO:0023019 IDA signal transduction involved in regulation of gene expression
GO:0030178 IMP negative regulation of Wnt signaling pathway
GO:0030308 IEA negative regulation of cell growth
GO:0031648 IEA protein destabilization
GO:0035050 IGI embryonic heart tube development
GO:0042074 IMP cell migration involved in gastrulation
GO:0042661 IMP regulation of mesodermal cell fate specification
GO:0042662 IMP negative regulation of mesodermal cell fate specification
GO:0042789 IEA mRNA transcription from RNA polymerase II promoter
GO:0043565 IDA sequence-specific DNA binding
GO:0044212 IDA transcription regulatory region DNA binding
GO:0044798 IDA nuclear transcription factor complex
GO:0045595 IMP regulation of cell differentiation
GO:0045597 IDA positive regulation of cell differentiation
GO:0045732 IDA positive regulation of protein catabolic process
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0045995 IMP regulation of embryonic development
GO:0046982 IDA protein heterodimerization activity
GO:0048568 IMP embryonic organ development
GO:0048617 IMP embryonic foregut morphogenesis
GO:0048643 IDA positive regulation of skeletal muscle tissue development
GO:0048863 IMP stem cell differentiation
GO:0048866 IDA stem cell fate specification
GO:0050821 IEA protein stabilization
GO:0060070 IDA canonical Wnt signaling pathway
GO:0060214 IGI endocardium formation
GO:0060807 IMP regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification
GO:0060913 IEA cardiac cell fate determination
GO:0060956 IGI endocardial cell differentiation
GO:0061009 IMP common bile duct development
GO:0061010 IMP gall bladder development
GO:0061031 IMP endodermal digestive tract morphogenesis
GO:0072001 IEA renal system development
GO:0072091 IDA regulation of stem cell proliferation
GO:0090090 IEA negative regulation of canonical Wnt signaling pathway
GO:2000035 IMP regulation of stem cell division
GO:2000043 IMP regulation of cardiac cell fate specification

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000041341 sox32 SRY-box containing gene 32 protein_coding Danio_rerio
ENSDARG00000041345 sox17 SRY-box containing gene 17 protein_coding Danio_rerio
ENSG00000164736 SOX17 SRY (sex determining region Y)-box 17 protein_coding Homo_sapiens

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