C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cAMP responsive element binding protein 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000025958 Creb1 10090 + 1:64532645-64604548 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000049932 Creb1-004 64532809-64601257 protein_coding
  ENSMUST00000087366 Creb1-001 64532819-64604548 protein_coding
  ENSMUST00000171164 Creb1-008 64532797-64597571 protein_coding
  ENSMUST00000185594 Creb1-002 64532645-64597695 protein_coding
  ENSMUST00000186335 Creb1-005 64532832-64575113 processed_transcript
  ENSMUST00000187035 Creb1-010 64560925-64562566 retained_intron
  ENSMUST00000187811 Creb1-003 64532809-64578216 protein_coding
  ENSMUST00000188855 Creb1-011 64532804-64558939 retained_intron
  ENSMUST00000190348 Creb1-007 64532894-64597477 protein_coding
  ENSMUST00000190876 Creb1-006 64532859-64597467 nonsense_mediated_decay
  ENSMUST00000190979 Creb1-009 64576388-64579150 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000049932ENSMUST00000087366ENSMUST00000171164ENSMUST00000187811ENSMUST00000190348
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000049932 2.412±1.15 2.171±0.65 N/A N/A 2.667±0.70 1.593±0.28 0.942±0.11 1.514±0.24 1.009±0.36 3.896±0.20 0.393±0.04 3.106±0.77 1.335±0.32 N/A
ENSMUST00000087366 1.347±0.60 0.857±0.00 4.242±0.07 5.594±2.56 1.471±0.27 0.879±0.19 0.982±0.16 1.366±0.45 1.801±1.40 2.418±0.44 1.386±0.29 3.172±1.56 2.107±0.86 0.818±0.49
ENSMUST00000171164 N/A 1.245±0.00 N/A N/A N/A N/A N/A N/A 0.841±0.00 N/A N/A N/A N/A 3.877±0.00
ENSMUST00000187811 3.193±1.23 2.847±0.98 N/A N/A 6.507±2.89 3.540±0.77 1.916±0.02 1.821±0.41 1.155±0.00 5.233±1.23 N/A 7.320±2.65 N/A N/A
ENSMUST00000190348 1.578±0.01 5.562±2.61 N/A N/A 4.049±0.70 4.674±1.27 N/A 2.872±0.84 1.322±0.37 N/A N/A 8.744±3.15 6.971±0.00 1.432±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006YW CIL_0006YW_0002 CGP 1:64029447-64604548
CIL_0006YR CIL_0006YR_0002 CGP 1:64532645-64617242

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000790 IDA nuclear chromatin
GO:0000978 IEA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 IEA RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001102 IEA RNA polymerase II activating transcription factor binding
GO:0001190 IEA RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677 IDA DNA binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IEA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IDA transcription factor complex
GO:0005719 IEA nuclear euchromatin
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IDA regulation of transcription, DNA-templated
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006468 ISO protein phosphorylation
GO:0007409 IMP axonogenesis
GO:0007595 IMP lactation
GO:0007613 IMP memory
GO:0007623 IDA circadian rhythm
GO:0008361 IGI regulation of cell size
GO:0010033 ISO response to organic substance
GO:0010944 IEA negative regulation of transcription by competitive promoter binding
GO:0019899 IEA enzyme binding
GO:0021983 IMP pituitary gland development
GO:0030879 IMP mammary gland development
GO:0033363 IMP secretory granule organization
GO:0033762 IMP response to glucagon
GO:0035497 IEA cAMP response element binding
GO:0040018 IMP positive regulation of multicellular organism growth
GO:0042493 IDA response to drug
GO:0043565 IDA sequence-specific DNA binding
GO:0045600 IGI positive regulation of fat cell differentiation
GO:0045672 IDA positive regulation of osteoclast differentiation
GO:0045893 IGI positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046887 IMP positive regulation of hormone secretion
GO:0046889 IGI positive regulation of lipid biosynthetic process
GO:0050821 IMP protein stabilization
GO:0060428 IMP lung epithelium development
GO:0060430 IMP lung saccule development
GO:0060509 IMP Type I pneumocyte differentiation
GO:0071294 IDA cellular response to zinc ion
GO:0071363 IDA cellular response to growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000053586 creb1a cAMP responsive element binding protein 1a protein_coding Danio_rerio
ENSDARG00000093420 creb1b cAMP responsive element binding protein 1b protein_coding Danio_rerio
ENSG00000118260 CREB1 cAMP responsive element binding protein 1 protein_coding Homo_sapiens

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