C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: cAMP responsive element binding protein 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000118260 CREB1 9606 + 2:207529737-207603431 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000353267 CREB1-002 207529912-207603431 protein_coding
  ENST00000414681 CREB1-009 207550261-207560348 protein_coding
  ENST00000418081 CREB1-014 207560314-207596949 nonsense_mediated_decay
  ENST00000421139 CREB1-007 207529940-207577631 protein_coding
  ENST00000430624 CREB1-003 207529737-207597789 protein_coding
  ENST00000432329 CREB1-001 207529892-207603431 protein_coding
  ENST00000445803 CREB1-005 207529923-207570321 protein_coding
  ENST00000446449 CREB1-017 207597165-207599182 processed_transcript
  ENST00000448277 CREB1-011 207559188-207596949 protein_coding
  ENST00000451164 CREB1-018 207597348-207599756 processed_transcript
  ENST00000452474 CREB1-006 207530104-207567556 protein_coding
  ENST00000455757 CREB1-016 207575286-207578065 protein_coding
  ENST00000457101 CREB1-010 207559226-207570288 protein_coding
  ENST00000464407 CREB1-012 207559171-207568150 retained_intron
  ENST00000480189 CREB1-013 207559122-207571777 processed_transcript
  ENST00000494094 CREB1-008 207530072-207567710 retained_intron
  ENST00000494983 CREB1-015 207576636-207597458 processed_transcript

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000353267ENST00000430624ENST00000432329ENST00000448277ENST00000455757ENST00000494983
Transcript ID Adipose Adrenal Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000353267 2.751±0.00 2.903±0.00 1.203±0.65 2.183±0.66 1.431±0.55 1.279±0.03 2.700±0.00 2.658±2.16 2.470±0.00 1.583±0.00 1.875±1.30 1.517±0.14 N/A
ENST00000430624 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 4.767±0.00
ENST00000432329 N/A N/A 1.068±0.35 1.411±0.00 1.100±0.36 0.701±0.18 0.682±0.00 0.728±0.27 1.832±0.04 0.191±0.00 1.276±0.39 1.198±0.00 2.327±0.42
ENST00000448277 N/A N/A N/A N/A N/A N/A N/A N/A N/A 1.338±0.00 N/A N/A N/A
ENST00000455757 N/A N/A N/A N/A 7.193±0.00 N/A N/A N/A N/A N/A N/A N/A N/A
ENST00000494983 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A 15.260±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0006YW CIL_0006YW_0001 CGP 2:207074137-207603431
CIL_0006YR CIL_0006YR_0001 CGP 2:207529737-207625928

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000790 IEA nuclear chromatin
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 IDA RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077 IC RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001102 IPI RNA polymerase II activating transcription factor binding
GO:0001190 IDA RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0002224 TAS toll-like receptor signaling pathway
GO:0002755 TAS MyD88-dependent toll-like receptor signaling pathway
GO:0002756 TAS MyD88-independent toll-like receptor signaling pathway
GO:0003677 IEA DNA binding
GO:0003700 IEA:IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003712 TAS transcription cofactor activity
GO:0005515 IPI:IEA protein binding
GO:0005634 IDA nucleus
GO:0005654 TAS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005719 IDA nuclear euchromatin
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006366 IDA transcription from RNA polymerase II promoter
GO:0006468 IDA protein phosphorylation
GO:0007165 TAS signal transduction
GO:0007173 TAS epidermal growth factor receptor signaling pathway
GO:0007202 TAS activation of phospholipase C activity
GO:0007219 TAS Notch signaling pathway
GO:0007268 TAS synaptic transmission
GO:0007409 IEA axonogenesis
GO:0007411 TAS axon guidance
GO:0007595 IEA lactation
GO:0007613 IEA memory
GO:0007623 ISS circadian rhythm
GO:0008361 IEA regulation of cell size
GO:0008543 TAS fibroblast growth factor receptor signaling pathway
GO:0010033 IDA response to organic substance
GO:0010944 IDA negative regulation of transcription by competitive promoter binding
GO:0016032 IEA viral process
GO:0019899 IPI enzyme binding
GO:0021983 IEA pituitary gland development
GO:0030879 IEA mammary gland development
GO:0033363 IEA secretory granule organization
GO:0033762 ISS response to glucagon
GO:0034134 TAS toll-like receptor 2 signaling pathway
GO:0034138 TAS toll-like receptor 3 signaling pathway
GO:0034142 TAS toll-like receptor 4 signaling pathway
GO:0034146 TAS toll-like receptor 5 signaling pathway
GO:0034162 TAS toll-like receptor 9 signaling pathway
GO:0034166 TAS toll-like receptor 10 signaling pathway
GO:0035497 IDA cAMP response element binding
GO:0035666 TAS TRIF-dependent toll-like receptor signaling pathway
GO:0038095 TAS Fc-epsilon receptor signaling pathway
GO:0038123 TAS toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 TAS toll-like receptor TLR6:TLR2 signaling pathway
GO:0040018 IEA positive regulation of multicellular organism growth
GO:0042493 IEA response to drug
GO:0043565 IEA sequence-specific DNA binding
GO:0045087 TAS innate immune response
GO:0045600 ISS positive regulation of fat cell differentiation
GO:0045672 IEA positive regulation of osteoclast differentiation
GO:0045893 ISS positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046887 IEA positive regulation of hormone secretion
GO:0046889 ISS positive regulation of lipid biosynthetic process
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0048015 TAS phosphatidylinositol-mediated signaling
GO:0050821 ISS protein stabilization
GO:0051403 TAS stress-activated MAPK cascade
GO:0060428 IEA lung epithelium development
GO:0060430 IEA lung saccule development
GO:0060509 IEA Type I pneumocyte differentiation
GO:0071294 IEA cellular response to zinc ion
GO:0071363 IEA cellular response to growth factor stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000053586 creb1a cAMP responsive element binding protein 1a protein_coding Danio_rerio
ENSDARG00000093420 creb1b cAMP responsive element binding protein 1b protein_coding Danio_rerio
ENSMUSG00000025958 Creb1 cAMP responsive element binding protein 1 protein_coding Mus_musculus

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