C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: zeta-chain (TCR) associated protein kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000026117 Zap70 10090 + 1:36761798-36782816 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000027291 Zap70-001 36761798-36782816 protein_coding
  ENSMUST00000185871 Zap70-005 36766934-36771067 protein_coding
  ENSMUST00000186624 Zap70-004 36770992-36772375 retained_intron
  ENSMUST00000190128 Zap70-002 36778984-36782815 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENSMUST00000027291ENSMUST00000185871ENSMUST00000186624ENSMUST00000190128
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENSMUST00000027291 0.798±0.44 0.711±0.20 0.436±0.01 0.727±0.28 13.780±5.72 0.617±0.37 0.164±0.04 0.641±0.44 0.076±0.05 1.833±0.37 0.204±0.16 0.956±0.44 0.311±0.21 0.675±0.30
ENSMUST00000185871 N/A N/A N/A N/A N/A N/A N/A 0.403±0.00 N/A 3.731±0.00 0.169±0.00 2.268±0.37 N/A N/A
ENSMUST00000186624 N/A N/A N/A N/A N/A N/A N/A N/A 0.018±0.00 N/A N/A N/A N/A N/A
ENSMUST00000190128 N/A N/A N/A N/A N/A N/A 0.054±0.02 N/A 6.054±4.29 N/A 0.129±0.10 0.414±0.15 0.175±0.05 0.278±0.00

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002U8 CIL_0002U8_0002 CGP 1:36698116-36782816
CIL_00029X CIL_00029X_0002 CGP 1:36761798-36943666

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001772 IDA immunological synapse
GO:0001784 IPI phosphotyrosine binding
GO:0004672 IDA protein kinase activity
GO:0004713 IDA protein tyrosine kinase activity
GO:0004715 IEA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 IDA ATP binding
GO:0005737 IDA cytoplasm
GO:0005829 IDA cytosol
GO:0005886 IDA plasma membrane
GO:0005911 IDA cell-cell junction
GO:0006468 IDA protein phosphorylation
GO:0006955 IEA immune response
GO:0018108 ISO peptidyl-tyrosine phosphorylation
GO:0035556 IMP intracellular signal transduction
GO:0042101 ISO T cell receptor complex
GO:0043366 IGI beta selection
GO:0045059 IMP positive thymic T cell selection
GO:0045060 IMP negative thymic T cell selection
GO:0045061 IMP thymic T cell selection
GO:0045121 IEA membrane raft
GO:0045582 IMP positive regulation of T cell differentiation
GO:0046638 IMP positive regulation of alpha-beta T cell differentiation
GO:0046641 IGI positive regulation of alpha-beta T cell proliferation
GO:0046777 IDA protein autophosphorylation
GO:0050850 IMP positive regulation of calcium-mediated signaling
GO:0050852 IMP T cell receptor signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000015752 zap70 zeta-chain (TCR) associated protein kinase protein_coding Danio_rerio
ENSG00000115085 ZAP70 zeta-chain (TCR) associated protein kinase 70kDa protein_coding Homo_sapiens

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