C-It-Loci: A knowledge database for tissue-enriched loci.

Institute of Cardiovascular Regeneration, Goethe-University Frankfurt am Main

Gene Info

Description: zeta-chain (TCR) associated protein kinase 70kDa
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000115085 ZAP70 9606 + 2:97713560-97739862 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264972 ZAP70-001 97713560-97739860 protein_coding
  ENST00000451498 ZAP70-008 97734406-97739498 protein_coding
  ENST00000463643 ZAP70-004 97724461-97739862 processed_transcript
  ENST00000483781 ZAP70-002 97713582-97733782 retained_intron
  ENST00000487283 ZAP70-003 97732929-97739859 retained_intron
  ENST00000489250 ZAP70-007 97737822-97738577 retained_intron
  ENST00000495754 ZAP70-006 97735230-97738011 retained_intron
  ENST00000498836 ZAP70-005 97732702-97733424 retained_intron

Expression Patterns

Heat Map
Numeric Values
Transcript'; AdiposeAdrenalBladderBrainBreastColonHeartKidneyLiverLungMuscleOvaryPlacentaTestisENST00000264972ENST00000451498ENST00000463643ENST00000483781ENST00000487283ENST00000495754ENST00000498836
Transcript ID Adipose Adrenal Bladder Brain Breast Colon Heart Kidney Liver Lung Muscle Ovary Placenta Testis
ENST00000264972 0.280±0.00 7.358±0.00 N/A N/A 0.257±0.07 N/A N/A N/A 0.346±0.00 3.060±1.65 N/A 0.700±0.08 0.588±0.30 0.770±0.03
ENST00000451498 N/A N/A N/A N/A 0.308±0.00 0.202±0.05 N/A 0.371±0.00 N/A 3.892±0.00 N/A 0.645±0.00 0.650±0.29 0.864±0.00
ENST00000463643 N/A N/A N/A N/A N/A N/A 0.131±0.00 0.243±0.00 0.043±0.00 N/A N/A 0.318±0.00 0.303±0.00 1.157±0.00
ENST00000483781 N/A N/A 0.812±0.00 0.155±0.00 0.407±0.00 N/A N/A N/A 0.154±0.00 N/A N/A N/A N/A N/A
ENST00000487283 N/A 7.391±0.00 N/A 0.025±0.00 0.311±0.00 N/A 0.045±0.03 0.151±0.00 0.025±0.00 2.549±0.00 0.021±0.00 0.417±0.07 0.085±0.00 0.370±0.00
ENST00000495754 N/A N/A N/A 0.145±0.00 N/A N/A 0.175±0.00 0.339±0.00 0.505±0.05 N/A 0.387±0.25 N/A N/A N/A
ENST00000498836 N/A N/A N/A N/A 0.789±0.00 N/A N/A N/A N/A N/A N/A 1.188±0.00 N/A N/A

Conserved Regions

Region IDSub-RegionRegion TypePosition
CIL_0002U8 CIL_0002U8_0001 CGP 2:97655963-97739862
CIL_00029X CIL_00029X_0001 CGP 2:97713560-97995891

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001772 IEA immunological synapse
GO:0001784 IEA phosphotyrosine binding
GO:0002250 TAS adaptive immune response
GO:0004672 IEA protein kinase activity
GO:0004713 IDA:IEA protein tyrosine kinase activity
GO:0004715 TAS:IEA non-membrane spanning protein tyrosine kinase activity
GO:0005515 IPI protein binding
GO:0005524 NAS:IEA ATP binding
GO:0005737 TAS:IEA cytoplasm
GO:0005829 TAS cytosol
GO:0005886 IDA plasma membrane
GO:0005911 IEA cell-cell junction
GO:0006468 IDA:IEA protein phosphorylation
GO:0006955 IDA immune response
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0018108 IDA peptidyl-tyrosine phosphorylation
GO:0030217 NAS T cell differentiation
GO:0035556 NAS:IEA intracellular signal transduction
GO:0042101 IDA T cell receptor complex
GO:0042110 TAS T cell activation
GO:0042113 TAS B cell activation
GO:0043366 IEA beta selection
GO:0045059 IDA positive thymic T cell selection
GO:0045060 IEA negative thymic T cell selection
GO:0045061 IEA thymic T cell selection
GO:0045121 IDA membrane raft
GO:0045582 IDA positive regulation of T cell differentiation
GO:0046638 IEA positive regulation of alpha-beta T cell differentiation
GO:0046641 IEA positive regulation of alpha-beta T cell proliferation
GO:0046777 IEA protein autophosphorylation
GO:0050850 IEA positive regulation of calcium-mediated signaling
GO:0050852 TAS T cell receptor signaling pathway
GO:0070489 TAS T cell aggregation
GO:0072678 TAS T cell migration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000015752 zap70 zeta-chain (TCR) associated protein kinase protein_coding Danio_rerio
ENSMUSG00000026117 Zap70 zeta-chain (TCR) associated protein kinase protein_coding Mus_musculus

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